The Preparation of Nitriles.

Synthesis, characterization and optical properties of polyvinyl alcohol–cerium oxide nanocomposite films

“…[7] Synthesis of nitriles using the concept of green chemistry has been considered to be a great scientific challenge. [8] Usually synthesis of nitriles is accomplished by substitution reactions of alkyl and aryl halides with metal cyanides, [9] oxidation of primary amines, [10] dehydration of primary and secondary amides, [11] or dehydration of aldoximes with dehydrating agents. [12] Other reported methods for the synthesis of nitriles include a one-pot reaction of aldehydes and hydroxylammonium chloride using reagents such as I 2 =NH 3 =tetrahydrofuran (THF), [13] NaN 3 =AlCl 3 , [14] and dimethylsulfoxide (DMSO)-I 2 .…”

Synthesis of [14C] labeled 2‐methoxypyrimidine‐5‐carboxylic acid

“…3 Aryl nitriles have been prepared by cyanation of iodides or bromides using CuCN or KCN in absence of solvent or in solvents like pyridine, quinoline, DMF, NMP at elevated temperature. [4][5][6][7][8][9][10][11] Under Von Braun conditions the reaction of 5-bromo-2-methoxypyrimidine with [ 14 C] CuCN in DMF at 1451C for 48 h did not yield cyano derivative.…”

Enamines and iminium salts from amido-acids

“…J. Chem. Downloaded from www.nrcresearchpress.com by 13 Murakoshi's work (6) has delineated the cyclization of o-acylaminocarboxylic acids to cyclic imines and iminium salts (6, 7). We repeated his work using the commercially available 22.…”