The preparation of highly ordered MCM-41 with extremely low surfactant concentration

Cai, Qiang; Lin, Wenliang; Xiao, Feng‐Shou; Pang, Wenqin; Chen, Xi-Hua; Bensan, Zou

doi:10.1016/s1387-1811(99)00082-7

Cited by 242 publications

(113 citation statements)

References 23 publications

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“…2+ /PO4 3− @MSNs The MSNs were synthesized as described in our previous studies 18,19) . Typical syntheses of Ca 2+ @MSNs and PO4 3− @ MSNs were as follows: 0.900 g of sodium dihydrogen phosphate (NaH 2PO4•2H2O) and 0.952 g of anhydrous calcium chloride (CaCl2) were separately dissolved in a sealed vial with 100 mL of distilled water and stirred for 30 min at room temperature.…”

Section: Preparation Of Msns and Camentioning

confidence: 99%

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

et al. 2014

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Section: Preparation Of Msns and Camentioning

confidence: 99%

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

et al. 2014

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“…[1][2][3][4][5] The MSN materials with well-ordered cylindrical pore structures, such as MCM-41 and SBA-15, have attracted special interest in the biomedical field. 1 The large surface areas and pore volumes of these materials allow the efficient adsorption of a wide range of molecules, including small drugs, 6-10 therapeutic proteins, [11][12][13] antibiotics, 14,15 and antibodies.…”

mentioning

confidence: 99%

Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

Zhao¹,

Sun²,

Zhang³

et al. 2011

ACS Nano

504

440

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The interactions of mesoporous silica nanoparticles (MSNs) of different particle sizes and surface properties with human red blood cell (RBC) membranes were investigated by membrane filtration, flow cytometry, and various microscopic techniques. Small MCM-41-type MSNs (∼100 nm) were found to adsorb to the surface of RBCs without disturbing the membrane or morphology. In contrast, adsorption of large SBA-15-type MSNs (∼600 nm) to RBCs induced a strong local membrane deformation leading to spiculation of RBCs, internalization of the particles, and eventual hemolysis. In addition, the relationship between the degree of MSN surface functionalization and the degree of its interaction with RBC, as well as the effect of RBC−MSN interaction on cellular deformability, were investigated. The results presented here provide a better understanding of the mechanisms of RBC−MSN interaction and the hemolytic activity of MSNs and will assist in the rational design of hemocompatible MSNs for intravenous drug delivery and in vivo imaging. R ecent advancements in particle size and morphology control of mesoporous materials have led to the creation of nano-and submicrometer-sized mesoporous silica nanoparticles (MSNs). [1][2][3][4][5] The MSN materials with well-ordered cylindrical pore structures, such as MCM-41 and SBA-15, have attracted special interest in the biomedical field. 1 The large surface areas and pore volumes of these materials allow the efficient adsorption of a wide range of molecules, including small drugs, 6-10 therapeutic proteins, 11-13 antibiotics, 14,15 and antibodies. 16 Therefore, these materials have been proposed for use as potential vehicles for biomedical imaging, real-time diagnosis, and controlled delivery of multiple therapeutic agents. [6][7][8]10,[17][18][19][20][21][22][23][24][25] Despite the considerable interest in the biomedical applications of MSNs, relatively few studies have been published on the biocompatibility of the two most common types of MSNs (MCM-41 and SBA-15). [26][27][28][29] Asefa and co-workers reported that the cellular bioenergetics (cellular respiration and ATP levels) were inhibited remarkably by large SBA-15 nanoparticles, but the inhibition was greatly reduced by smaller MCM-41-type nanoparticles. 26 These differences in the disruption of cellular bioenergetics are believed to be caused by the different surface areas, number of surface silanol groups, and/or particle sizes of both types of material. A recent study by Kohane and collaborators on the systemic effects of MCM-41 (particle size ∼150 nm) and SBA-15 (particle size ∼800 nm) MSNs in live animals revealed interesting findings regarding their biocompatibility. 27 While large doses of mesoporous silicas administered subcutaneously to mice appear to be relatively harmless, the same doses given intravenously or intraperitoneally were lethal. 27 A possible reason for the severe systemic toxicity of MSNs when injected intravenously could be the interactions of the nanoparticles with blood cells.Our initial studies...

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“…The synthesis of mesoporous silica NPs is done by modifying the Stöber method, adding surfactants that behave like templates, and will later be chemically or thermally removed [25][26][27] (Figure 10). Pores size of 10 and 300 Å have been reported along with different porous structured nanophases, using a replica of the surfactant template ( Figure 11).…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

“…Pores size of 10 and 300 Å have been reported along with different porous structured nanophases, using a replica of the surfactant template ( Figure 11). During the synthesis of mesoporous SiO2 NPs, fine synthetic control will result in high surface areas with well controlled particle sizes and shapes that render these NPs very interesting [25][26][27][28][29]. …”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Silica and ORMOSIL nanoparticles for gene delivery

Matos¹,

Monteiro²,

Goncavles³

2015

Nano Based Drug Delivery

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The preparation of highly ordered MCM-41 with extremely low surfactant concentration

Cited by 242 publications

References 23 publications

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

Silica and ORMOSIL nanoparticles for gene delivery

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