The Preparation of Heterocyclic Sulfonamides¹

The Effect of Intravenously Administered 6063, the Carbonic Anhydrase Inhibitor, 2-Acetylamino-1,3,4-Thiadiazole-5-Sulfonamide, on Fluid and Electrolytes in Normal Subjects and Patients With Congestive Heart Failure

“…Recently a series of more active carbonic anhydrase inhibitors of the sulfonamide group has been developed (11). One of these, the heterocyclic sulfonamide, 6063 (2-acetylamino-1,3,4-thiadiazole-5-sulfonamide), is a carbonic anhydrase inhibitor which is 50 to 400 times more effective than sulfanilamide and nontoxic in effective doses (12).…”

Bis(5-acetylamino-1,3,4-thiadiazole-2-sulfon)amide dihydrate

“…The title compound (1) was isolated as an impurity in the chemical synthesis of the commercial diuretic known by its generic name of acetazolamide (2) (Roblin & Clapp, 1950).…”

Structure of 5-amino-1,3,4-thiadiazole-2-sulfonamide, an inhibitor of the enzyme carbonic anhydrase

“…The synthesis of 5-amino-l,3,4-thiadiazole-2-sulfonamide (Hats) was originally described by Roblin & Clapp (1950). We have obtained Hats by a different method, following that published by Young, Wood, Eichler, Vaughan & Anderson (1956) for other 1,3,4-thiadiazolesulfonamides.…”