The Preparation of Furan-2,5-dicarboxylic Acid¹

Synthesis, Chemistry and Applications of 5‐Hydroxymethyl‐furfural and Its Derivatives

“…The latter was oxidised with nitric acid to afford dimethyl 2,5-furandicarboxylate, which, after the alkaline hydrolysis gave FDCA in 50% yield. (Scheme 28) It has been suggested 145,207,211 that the reaction is more convenient and efficient when 5-chloromethylfuroate is converted into methyl 5-acylmethyl-2-furoate 66 and the latter was oxidised to 2,5-furandicarboxylate. But according to my observation, it prolongs the time of the reaction and does not improve the yield much.…”

Synthesis, chemistry and applications of 5-hydroxymethyl-furfural and its derivatives

“…[200][201][202][203][204] The second class includes reactions of the oxidation of various 2,5-disubstituted furans utilising a variety of inorganic oxidants. Several papers have been published, describing the synthesis of FDCA from furfural [205][206][207][208][209][210][211][212] . Furfural was oxidised to 2-furoic acid with nitric acid and the latter was subsequently converted to its methyl ester.…”

2‐(Guanidiniocarbonyl)furans as a New Class of Potential Anion Hosts: Synthesis and First Binding Studies

“…[10,11] Chloromethylation of commercially available methyl furan-2-carboxylate (6) with paraformaldehyde, zinc chloride and anhydrous hydrogen chlo-ride yielded 7. The chloro substituent was replaced according to a literature procedure [12,13] to obtain 8 by heating 7 with anhydrous sodium acetate in acetic acid containing acetic anhydride. The selective hydrolysis of the acetic acid ester group of 8 by reaction with NaOMe in methanol solution gave the furfuryl alcohol 9.…”