The Preparation Of Compressed Tablets: Part III.—A Study of the Value of Potato Starch and Alginic Acid as Disintegrating Agents

Berry, H.; Ridout, C. W.

doi:10.1111/j.2042-7158.1950.tb12981.x

Cited by 38 publications

(3 citation statements)

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“…In general, small pores decrease the ability of a fluid to enter the powder compact, whereas a high porosity, associated to a large void space, may lower the force induced by the swelling of excipients. Therefore, a lower swelling force increases the time to break up inter -particle bonds [47, 68]. However, the complex pore structure cannot by adequately represented by one single parameter such as the total porosity.…”

Section: Factors Affecting Liquid Penetrationmentioning

confidence: 99%

A Review of Disintegration Mechanisms and Measurement Techniques

2017

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Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically powder compacts consisting of several different excipients in addition to the API. Excipients are added to a formulation in order to achieve the desired fill weight of a dosage form, to improve the processability or to affect the drug release behaviour in the body. These complex porous systems undergo different mechanisms when they come in contact with physiological fluids. The performance of a drug is primarily influenced by the disintegration and dissolution behaviour of the powder compact. The disintegration process is specifically critical for immediate-release dosage forms. Its mechanisms and the factors impacting disintegration are discussed and methods used to study the disintegration in-situ are presented. This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics.

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Section: Factors Affecting Liquid Penetrationmentioning

confidence: 99%

A Review of Disintegration Mechanisms and Measurement Techniques

2017

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“…ERRY AND RIDOUT have described the use of powdered alginic acid as a tablet disintegrant (1) and we have similarly noted and reported this property (2) for the spray-dried powdered acid form of carboxyrnethylcellulose (HCMC). Some recent publications have also described the cation exchange properties of alginic acid (3, 4, 5) and chemically modified cotton fabrics (6).…”

Section: Preparation and Titration Curves By Joseph V Swintoskytmentioning

confidence: 85%

Properties and applications of powdered polysaccharide acids. I. Preparation and titration curves

Swintosky

Kennon

Tingstad

1955

Journal of the American Pharmaceutical Association (Scientific

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“…Medium pressure allows just enough space so that when the starch swells, it exerts pressure on the granules to cause disintegration. High pressure, producing low porosity, decreases the ability of fluid to enter; so, disintegration is again slow (24,25).…”

Section: Drug In Blood Othermentioning

confidence: 99%

An Investigation of the Potential of Soy Cellulose as a Tablet Disintegrant

Desai¹

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Scanning Electron Micrographs of soy cellulose (Emcosoy) particles were studied to further the understanding of the morphology of the substance and thereby to increase the comprehension of how the excipient functions in tablet systems. Bulk swelling and water uptake were studied for Emcosoy, CLD II, corn Starch, and Ac-Di-Sol. Emcosoy had maximum swelling about 56%; followed by CLD II 49% and Ac-Di-Sol 9%. No swelling was observed in Corn Starch. An ideal disintegrant should perform uniformly in pH range of gastrointestinal tract in order to disintegrate the tablet. When Emcosoy and Ac-Di-Sol were tested against various pH values, there was no significant difference in swelling of these disintegrants. Since alcohol and sodium lauryl

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The Preparation Of Compressed Tablets: Part III.—A Study of the Value of Potato Starch and Alginic Acid as Disintegrating Agents

Cited by 38 publications

References 1 publication

A Review of Disintegration Mechanisms and Measurement Techniques

A Review of Disintegration Mechanisms and Measurement Techniques

Properties and applications of powdered polysaccharide acids. I. Preparation and titration curves

An Investigation of the Potential of Soy Cellulose as a Tablet Disintegrant

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