The preparation and stability of radioiodinated antipyrine for use in local blood flow determinations

Forrester, Donald W.; Spence, V. A.; Bell, Ingram; Hutchinson, F.; Walker, William F.

doi:10.1007/bf00252474

Cited by 13 publications

(2 citation statements)

References 3 publications

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“…The patients presented to the vascular laboratory for limb All patients underwent routine laboratory investigations including segmental limb blood pressures, skin blood flow measurements and a thermographic evaluation of the affected leg. Skin blood flows were determined by the radioisotope clearance technique using a stable compound of 1-125 CIodoantipyrine (125 I-4-IAP), specially prepared in the Medical Physics Department (Forrester et al, 1980). Twenty microlitres of (125 I-4-IAP) were injected intradermally with a 28 gauge needle such that a small papule was raised on the skin surface.…”

Section: Methodsmentioning

confidence: 99%

A rationale for skew flaps in below-knee amputation surgery

McCollum¹,

Spence

Walker

et al. 1985

Prosthetics &Amp; Orthotics International

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The use of thermography in the assessment of amputation levels has demonstrated a medial to lateral thermal gradient in many cases. In order to see whether this reflected a true medial to lateral skin blood flow gradient, a prospective study was set up to measure blood flow medially and laterally below the knee. Twenty-one patients, presenting for amputation assessment with end-stage peripheral vascular disease, were studied. Skin blood flows were measured using an intradermal radioisotope clearance technique. Results showed a highly significant difference between medial and lateral skin blood flows (t = 4.79; p < 0.001). In view of the significantly higher blood flow in the medial skin of the lower leg, it is suggested that a more medially based posterior below-knee amputation skin flap may be of more value in some patients.

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Section: Methodsmentioning

confidence: 99%

A rationale for skew flaps in below-knee amputation surgery

McCollum¹,

Spence

Walker

et al. 1985

Prosthetics &Amp; Orthotics International

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“…For this reason Iodine-labelled iodoantipyrine is not in general use for local blood flow determinations. However, we have reported on a simple method for preparing a stable solution of (4-124-1) IAP which does not undergo radiolysis to any extent-no more than one per cent free Iodine throughout its shelf time (Forrester et al, 1980). This preparation provides monoexponential clearance in every case (Fig.…”

Section: Skin Blood Flow By Radioisotope Clearancementioning

confidence: 99%

Assessment of tissue viability in relation to the selection of amputation level

Spence

McCollum

Walker

et al. 1984

Prosthetics &Amp; Orthotics International

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Assessment of the optimum level of amputation of an ischaemic limb can be exceptionally difficult. For this reason there has been an intensive effort, particularly in the past 20 years, to find suitable non-invasive ancillary methods to aid in the amputation level selection. This paper reviews three separate research and development areas which have evolved simultaneously in our laboratory: skin partial oxygen pressure, skin blood flow, and infrared thermography. The physiological basis for each of these measurements is discussed along with the merits and demerits of each.

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