The Preparation and Some Reactions of Fluorinated Cyclic Ketones

Organic Fluorine Chemistry

“…The geminal difluoro grouping is readily hydrolyzed, especially in an acidic medium, provided the difluoromethylene group is adjacent to a double bond [385][386][387], or nitrogen (388), or oxygen atoms [389,390). Acid hydrolysis of the difluoromethylene group in 4,4-dichloro-3,3-difluoro-I-phenylcyclobutene takes place preferentially to the dichloromethylene group (386).…”