The Preparation and Properties of Multilayer Cu-MTa2O5 Composite Coatings on Ti6Al4V for Biomedical Applications

Abstract

For the enhancement of the anticorrosion and antibacterial performance of the biomedical alloy Ti6Al4V, a novel Cu incorporated multilayer Ta2O5ceramic composite coating Cu-Ta2O5/Ta2O5/Ta2O5-TiO2/TiO2/Ti (coating codeCu-MTa2O5) was developed by radio frequency (RF) and direct current (DC) reactive magnetron sputtering. Meanwhile, to better display the multilayer Ta2O5 coating mentioned above, a monolayer Ta2O5 ceramic coating was deposited onto the surface of Ti6Al4V alloy as a reference. The surface morphology, microstructure, phase constituents, and elemental states of the coating were evaluated by atomic force microscopy, scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, respectively. The adhesion strength, wettability, anticorrosion and antibacterial properties of the coating were examined by a scratch tester, contact angle measurement, electrochemical workstations, and plate counting method, respectively. The results showed that the deposited coatings were amorphous and hydrophobic. Cu doped into the Ta2O5 coating existed as CuO and Cu2O. A Ta2O5-TiO2/TiO2/Ti multi-interlayer massively enhanced the adhesion strength of the coating, which was 2.9 times stronger than that of the monolayer Ta2O5coating. The multilayer Cu-MTa2O5 coating revealed a higher corrosion potential and smaller corrosion current density as compared to the uncoated Ti6Al4V, indicating the better anticorrosion performance of Ti6Al4V. Moreover, a 99.8% antibacterial effect of Cu-MTa2O5 coated against Staphylococcus aureuswas obtained.

Antibacterial Ti–Cu implants: A critical review on mechanisms of action

“…The antimicrobial agents are released upon implant insertion into the body, thereby resulting in proficient localized drug delivery. The antibacterial agents that have been typically used in this area include metal ions such as silver (Ag + ) [ 66 , 67 ], zinc (Zn 2+ ) [ 68 ], and copper (Cu 2+ ) [ 69 ], antibiotics like rifampin [ 70 ], bactericidal polymers such as polyelectrolyte multilayers [ 71 ] and chitosan [ 72 ], and antimicrobial peptides (AMP) like GL13K [ 73 ] and Mel4 [ 74 ].…”

Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis

“…Pure Ti and Ti 6 Al 4 V are routinely applied as implant materials despite their lack of significant antibacterial and bactericidal characteristics. Ag, Cu, and Zn are widely used as antibacterial agents and can strengthen the antibacterial or bactericidal properties of implants through various surface modification techniques, including plasma immersion ion implantation, plasma spraying, and magnetron sputtering. ,− Because the antimicrobial agents in implant materials will eventually run out, antimicrobial coatings based on the drug delivery cannot function for long-term periods. However, the risk of biofilms remains throughout the duration of the implant life cycle.…”

Microstructure, Wettability, Corrosion Resistance and Antibacterial Property of Cu-MTa2O5 Multilayer Composite Coatings with Different Cu Incorporation Contents

“…The plate counting method is the most common method for the quantitative evaluation of antibacterial properties of materials [41]. S. aureus is one of the common pathogens causing implant-related infection and implant inflammation [41].…”

“…The plate counting method is the most common method for the quantitative evaluation of antibacterial properties of materials [41]. S. aureus is one of the common pathogens causing implant-related infection and implant inflammation [41]. In this study, the antibacterial effect of the sample on S. aureus (ATCC6538, Guangzhou Institute of Microbiology, Guangzhou, China) was tested by the plate counting method.…”

“…Wettability is one of the important surface properties of implant materials that affect cell/bacterial response, which is generally evaluated by testing the surface contact angle [41]. Figure 9 is the test result of the water contact angle on the surface of the sample.…”