The preparation and properties of hybridized hydrogels based on cubic thiol-functionalized silsesquioxane covalently linked with poly(N-isopropylacrylamide)

Xu, Zhiqiang; Ni, Caihua; Yao, Baoquan; Tao, Lei; Zhu, Caichao; Han, Qingbang; Mi, Jiaquan

doi:10.1007/s00396-011-2510-0

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…Based on these advantages, the researches focused on the incorporation of POSS particles into the hydrogels for improving the mechanical properties, thermal properties, and deswelling ratio of gels have grown significantly. In different hybrid gels, POSS particles were combined with the hydrogel matrix through covalent combination or noncovalent combination, which determines the effect of modification directively . Moreover, due to the special characters, such as nanoscale size, three‐dimensional functionality, efficient cellular uptake, and low toxicity, POSS and its derivatives exhibit great potential in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…In different hybrid gels, POSS particles were combined with the hydrogel matrix through covalent combination or noncovalent combination, which determines the effect of modification directively. [26][27][28][29] Moreover, due to the special characters, such as nanoscale size, three-dimensional functionality, efficient cellular uptake, and low toxicity, POSS and its derivatives exhibit great potential in drug delivery. As a successful test, McCusker functionalized the water-soluble octa-ammonium (Oa)-POSS with a succinimidyl ester derivative of a BODIPY (boron dipyrromethane)dye to form an effective drug delivery system, which proves the potential of POSS in drug divery.…”

Section: Introductionmentioning

confidence: 99%

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Robust and stimuli‐responsive POSS hybrid PDMAEMA hydrogels for controlled drug release

Chen

Zeng

Liu

2016

J Biomedical Materials Res

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A new polyhedral oligomeric silsesquioxane (POSS) hybrid hydrogels were desinged and fabricated by introducing cationic octa-ammonium (Oa)-POSS) into chemically cross-linked cationic PDMAEMA hydrogels via in situ radical freezing polymerization. The prepared gels (shorten as OP-PD gels) show considerably improved properties through the effective incorporation and dispersion of Oa-POSS particles in gels. Comparing to the Oa-POSS-free gels, the hybrid gels own better mechanical properties with higher tensile and compressive strength. Meantime, except the decreased swelling ratio in acid condition, the OP-PD gels still keep excellent swelling ability with obvious pH and temperature double responsiveness, which is affected by the content of Oa-POSS slightly. All OP-PD gels exhibit an ultrarapid deswelling rate due to the interconnected micropores structure caused by freezing and the formation of microhydrophobic region around POSS particles. Moreover, the application potential of OP-PD gels in drug release was exploited by using flutamide as target drug, the result showed that the increased Oa-POSS could improve the drug loading ability, and OP-PD gels showed well controlled-release effect in simulated human stomachic condition. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2345-2355, 2016.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Robust and stimuli‐responsive POSS hybrid PDMAEMA hydrogels for controlled drug release

Chen

Zeng

Liu

2016

J Biomedical Materials Res

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“…Zeng prepared a series of rapid thermoresponsive POSS-containing PNIPA hydrogels by using POSS with various long flexible chains, and obvious hydrophobic nanodomains in gels were observed by atomic force micrography [30]. Octa (propylglycidyl ether)-POSS, mercapto-POSS, and octavinyl-POSS were also used in PNIPA gels to improve the deswelling rate and mechanical properties [31,32,33]. Moreover, POSS was proven to have good biocompatibility, which is more promising for use as a biomedical material [34,35].…”

Section: Introductionmentioning

confidence: 99%

POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness

et al. 2019

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In order to improve the performance of traditional sodium alginate (SA) hydrogels cross-linked by Ca2+ ions to meet greater application demand, a strategy was designed to structure novel SA-based gels (named OP-PN gels) to achieve both stimulus responsiveness and improved mechanical strength. In this strategy, the SA chains are co-cross-linked by CaCl2 and cationic octa-ammonium polyhedral oligomeric silsesquioxane (Oa-POSS) particles as the first network, and an organically cross-linked poly(N-isopropyl acrylamide) (PNIPA) network is introduced into the gels as the second network. Several main results are obtained from the synthesis and characterization of the gels. For OP-PN gels, their properties depend on the content of both uniformly dispersed Oa-POSS and PNIPA network directly. The increased Oa-POSS and PNIPA network content significantly improves both the strength and resilience of gels. Relatively, the increased Oa-POSS is greatly beneficial to the modulus of gels, and the increased PNIPA network is more favorable to advancing the tensile deformation of gels. The gels with hydrophilic PNIPA network exhibit better swelling ability and remarkable temperature responsiveness, and their volume phase transition temperature can be adjusted by altering the content of Oa-POSS. The deswelling rate of gels increases gradually with the increase of POSS content due to the hydrophobic Si–O skeleton of POSS. Moreover, the enhanced drug loading and sustained release ability of the target drug bovine serum albumin displays great potential for this hybrid gel in the biomedical field.

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“…17 PNIPAM based hydrogels were also prepared in the presence of a cross-linker and POSS-SH as a chain transfer agent by conventional free radical polymerization. 18 Octa( propylglycidyl ether) polyhedral oligomeric silsesquioxane was used as a nano cross-linking agent to prepare the cross-linked PNIPAM hydrogel networks with a high POSS content (up to 50 wt%). The authors studied swelling, deswelling and reswelling experiments with the POSS modified PNIPAM hydrogel.…”

Section: Introductionmentioning

confidence: 99%

POSS-induced enhancement of mechanical strength in RAFT-made thermoresponsive hydrogels

et al. 2015

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To understand the effect of polyhedral oligomeric silsesquioxane (POSS) moieties on the rheological properties of thermoresponsive hydrogels, poly(ethylene glycol) methyl ether methacrylate (PEGMA) based gels have been synthesized via conventional free radical polymerization (FRP) and reversible additionfragmentation chain transfer (RAFT) polymerization techniques. Two different chain transfer agents (CTAs), namely 4-cyano-4-(dodecylsulfanylthiocarbonyl) sulfanylpentanoic acid (CDP) and a POSS chainended CTA (POSS-CDP) have been employed for the RAFT polymerization of PEGMA in the presence of a di-functional cross-linker, di(ethylene glycol) dimethacrylate (DEGDMA). Swelling, deswelling and reswelling behaviors due to the introduction of the POSS moiety have been systematically examined and compared with the CDP based hydrogels at similar compositions. The surface topology and structural porosity of the hydrogel matrix are examined by field emission-scanning electron microscopy (FE-SEM). The mechanical behavior of the swollen hydrogels has been investigated through rheological measurements.Interestingly, we find that the mechanical stability of the hydrogels improved by increasing both the cross-linking density and total net fraction of the POSS moieties.

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The preparation and properties of hybridized hydrogels based on cubic thiol-functionalized silsesquioxane covalently linked with poly(N-isopropylacrylamide)

Cited by 20 publications

References 24 publications

Robust and stimuli‐responsive POSS hybrid PDMAEMA hydrogels for controlled drug release

Robust and stimuli‐responsive POSS hybrid PDMAEMA hydrogels for controlled drug release

POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness

POSS-induced enhancement of mechanical strength in RAFT-made thermoresponsive hydrogels

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