The preparation and applications of novel phosphazene crosslinked thermo and pH responsive hydrogels

Özay, Hava; Sahin, Ozdem; Koç, Ömer Kaan; Özay, Özgür

doi:10.1016/j.jiec.2016.07.043

Cited by 28 publications

(5 citation statements)

References 41 publications

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“…These pH-and temperature-sensitive particles protect the drug molecules inside the stomach, whereas it will be released through sudden squeezing of the carrier in the small intestine (and/or colon). Cross-linked poly(NIPAAm-co-VI) hydrogels with different co-monomer molar ratios were also synthesized by free radical polymerization in aqueous solutions using ammonium persulfate as initiator and TEMED as accelerator [25]. The release of Rhodamine 6G, used as a drug model, entrapped in these hydrogels, has been influenced by the pH and temperature of the release fluids.…”

Section: Introductionmentioning

confidence: 99%

Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells

et al. 2022

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The cellular internalization of drug carriers occurs via different endocytic pathways that ultimately involve the endosomes and the lysosomes, organelles where the pH value drops to 6.0 and 5.0, respectively. We aimed to design and characterize pH/temperature-responsive carriers for the effective delivery of the anti-tumoral drug doxorubicin. To this purpose, poly(N-isopropylacrylamide-co-vinylimidazole) was synthesized as an attractive pH/temperature-sensitive copolymer. Microspheres made of this copolymer, loaded with doxorubicin (MS-DXR), disintegrate in monodisperse nanospheres (NS-DXR) under conditions similar to that found in the bloodstream (pH = 7.4, temperature of 36 °C) releasing a small amount of payload. However, in environments that simulate the endosomal and lysosomal conditions, nanospheres solubilize, releasing the entire amount of drug. We followed the NS-DXR internalization using two cancer cell lines, hepatic carcinoma HepG2 cells and lung adenocarcinoma A549 cells. The data showed that NS-DXR are internalized to a greater extent by HepG2 cells than A549 cells, and this correlated with increased cytotoxicity induced by NS-DXR in HepG2 cells compared with A549 cells. Moreover, NS-DXR particles do not cause hemolysis and erythrocytes aggregation. Administered in vivo, NS-DXR localized in the liver and kidneys of mice, and the loading of DXR into NS resulted in the reduced renal clearance of DXR. In conclusion, the newly developed poly(N-isopropylacrylamide-co-vinyl imidazole) particles are biocompatible and may be introduced as carriers for doxorubicin to hepatic tumors.

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Section: Introductionmentioning

confidence: 99%

Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells

et al. 2022

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“…For phosphazene-tannic acid nanospheres rhodamine 6G was completely released at pH 7.0 for 12 h [ 33 ]. Hexakis [4-(acrylamido)phenoxy]cyclotriphosphazene crosslinked hydrogels were also applied for in vitro release of rhodamine 6G [ 34 ]. Cumulative release of rhodamine 6G during 30 h for media with pH 5.5 value was determined as 87%.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Macroinitiators Based on Polyorganophosphazenes for the Ring Opening Polymerization of N-Carboxyanhydrides

et al. 2021

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Among the various biocompatible amphiphilic copolymers, biodegradable ones are the most promising for the preparation of drug delivery systems since they are destroyed under physiological conditions, that, as a rule, reduce toxicity and provide controlled release of the drug. Hybrid graft-copolymers consisting of the main inorganic polyphosphazene chain and polypeptide side chains are of considerable interest for the development of delivery systems with a controlled degradation rate, since the main and side chains will have different degradation mechanisms (chemical and enzymatic hydrolysis, respectively). Variable particle degradation rate, controlled by the adjusting the composition of substituents, will allow selective delivery in vivo and controlled drug release. The present work proposes the preparation of biodegradable macroinitiators based on polyorganophosphazenes for the synthesis of hybrid copolymers. Synthesis of novel biodegradable macroinitiators based on polyorganophosphazenes was performed via macromolecular substitution of a polydichlorophosphazene chain with the sodium alcoholates, amines and amino acids. The composition of copolymers obtained was calculated using NMR. These polyorganophosphazenes bearing primary amino groups can be considered as convenient macroinitiators for the polymerization of NCA of α-amino acids in order to prepare hybrid copolymers polyphosphazene-graft-polypeptide. The developed macroinitiators were amphiphilic and self-assembled in the aqueous media into nanoparticles. Furthermore, the ability to encapsulate and release a model substance was demonstrated. In addition, the in vitro cytotoxicity of synthesized polymers was evaluated using two cell lines.

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“…While above the LCST, a hydrophobic aggregation is produced due to a coil‐to‐globule transition. Similarly, the hydrogels based on poly(NIPA) are in the swollen state below the LCST while in the shrunken state above the LCST [47]. 4‐VP is a commonly used monomer to fabricate the pH‐sensitive hydrogels [48].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Thermal and pH Dual Sensitive Hydrogel Based on 1,3‐Dipole Cycloaddition Reaction

Wei

Liu

Zhu

et al. 2020

Polymer Engineering & Sci

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In this study, thermal and pH dual sensitive hydrogels were prepared via Cu-free 1,3-dipole cycloaddition between two copolymers which were modified by azide and maleimide functional groups, respectively. First, the thermally sensitive terpolymers were fabricated via conventional free-radical polymerization of N-isopropylacrylamide, hydroxyethyl methacrylate (HEMA), and N,N-dimethylacrylamide (DMA). Then, polymeric dipolarophiles were synthesized via the esterification between the above terpolymers and N-maleoyl alanine. Similarly, the pH-sensitive terpolymers were also fabricated via conventional free-radical polymerization of 4-vinylpyridine, HEMA, and DMA, and then, polymeric dipoles were acquired via the decoration of the as-prepared terpolymers with 2-azidoacetic acid. Afterward, the smart hydrogels were fabricated via the aqueous 1,3-dipole cycloaddition reaction between the as-prepared polymeric dipolarophiles and dipoles without the use of catalysts. The results of swelling measurements confirm that the hydrogels possessed thermal and pH dual sensitivity. Moreover, the investigation of the behavior of oscillatory swelling shrinking indicates their sensitivity to temperature and pH was reversible and repeatable, which is of great significance for the repeated use of the prepared hydrogels. The proposed strategy demonstrates a great application prospects in the preparation of hydrogels as there were no catalysts and organic solvents employed. POLYM. ENG. SCI., 60:917-924, 2020.

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The preparation and applications of novel phosphazene crosslinked thermo and pH responsive hydrogels

Cited by 28 publications

References 41 publications

Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells

Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells

Synthesis and Characterization of Macroinitiators Based on Polyorganophosphazenes for the Ring Opening Polymerization of N-Carboxyanhydrides

Preparation and Characterization of Thermal and pH Dual Sensitive Hydrogel Based on 1,3‐Dipole Cycloaddition Reaction

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