The preoperative serum C-reactive protein level is a useful predictor of surgical site infections in patients undergoing appendectomy

Abstract

Preoperative elevation of the serum CRP level (> 65 mg/l) is a valuable predictor of SSI in patients undergoing appendectomy.

Are there reliable indicators predicting post-operative complications in acute appendicitis?

“…Our data showed CRP was the independent pre-operative predictor for post-operative complications. Shimazu et al reported that a CRP level >6.5 mg/ dl is associated with WI in adults [7]. We showed that CRP was related to post-operative complications in children.…”

Retrospective Multicenter Study on Risk Factors for Surgical Site Infections after Appendectomy for Acute Appendicitis

“…An explanation could be that patients with complex appendicitis have higher inflammatory parameters as a result of peritonitis and there is an interaction between these 2 factors [21]. Shimizu et al [14] showed that CRP levels higher than 65 is a risk factor for the development of an SSI. A closer look at this study reveals a much higher rate of SSI (16.3%).…”

“…Continuous data were dichotomized using clinically relevant cut-off points or based on previous publications [11,12,14]. After univariable analysis, factors with a p value of <0.30 were selected for multivariable analysis and entered in a logistic regression model.…”

“…Several studies have investigated factors that are associated with SSI in acute appendicitis including preoperative C-reactive protein (CRP) level, timing of appendectomy, technique of appendiceal stump closure, operative approach (laparoscopic versus open), duration of the operation, complex versus simple appendicitis, body temperature, American Society of Anesthesiology (ASA)-classification, age, body mass index (BMI) and gender [9,11,12,13,14,15,16]. Most studies however are single center and have strict inclusion and exclusion criteria.…”

Pre-operative CT predictors associated with 30-day adverse events in patients with appendiceal inflammatory masses who underwent immediate appendectomies

“…It is well known that patients with perforated appendicitis often develop subsequent abscesses, even if the appropriate surgery is performed. Several studies have shown that the risk of these post-operative adverse events can be predicted by specific clinical characteristics, surgical findings, and treatment-related factors [18][19][20][21]. To our knowledge, however, no previous study has assessed pre-operative CT findings to predict post-operative adverse events in patients who underwent immediate appendectomies to treat appendiceal inflammatory masses.…”