The Preoperative Lymphocyte-to-Monocyte Ratio is Prognostic of Clinical Outcomes for Patients with Liver-Only Colorectal Metastases in the Neoadjuvant Setting

Neofytou, Kyriakos; Smyth, Elizabeth; Giakoustidis, Alexandros; Khan, Aamir Z.; Williams, Roger; Cunningham, David; Mudan, Satvinder

doi:10.1245/s10434-015-4481-8

Cited by 47 publications

(42 citation statements)

References 26 publications

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“…The association between LMR and OS was reported in 44 studies enrolling 14,984 patients with various cancer types [8, 10–13, 15–17, 19–21, 23–27, 29–33, 35–40, 42–46, 48, 49, 51, 53–56, 58–62]. Five of the eligible 44 studies (11%) reported a non-statistically significant hazard ratio.…”

Section: Resultsmentioning

confidence: 98%

“…Eleven studies comprising 3,972 patients reported hazard ratios for CSS [7, 8, 11, 18, 19, 22, 24, 25, 44, 58, 59]. The effect of LMR on CSS among cancer subgroups is presented in Figure 4A.…”

Section: Resultsmentioning

confidence: 99%

“…The lower LMR was significantly associated with poor CSS in colorectal carcinoma (HR: 0.55, 95% CI: 0.42–0.71; P < 0.001), soft tissue sarcoma (HR: 0.38, 95% CI: 0.20–0.72; P = 0.003), Hodgkin's lymphoma (HR: 0.09, 95% CI: 0.04–0.21; P < 0.001) and other non-hematological malignancies (HR: 0.79, 95% CI: 0.68–0.91; P = 0.002). Fifteen studies comprising 6,440 patients reported hazard ratios for DFS [8, 9, 11, 14, 18, 20, 23, 24, 28, 30, 34, 38, 43, 45, 47]. The effect of LMR on DFS among cancer subgroups is presented in Figure 4B.…”

Section: Resultsmentioning

confidence: 99%

“…The calculated HRs could be not as dependable as those retrieved directly from reported statistics. Among the 50 studies providing HRs, five reported univariate hazard ratios, which could introduce a bias toward overestimation of the prognostic role of LMR [8, 18, 19, 33, 54]. In some studies, hazard ratios from multivariable analysis may not have been statistically significant, this might be attribute to inclusion of other markers of systemic inflammation in the multivariable model, which may provide similar information to LMR and thus lead to a non-statistically significant outcome [11, 24, 25].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

et al. 2016

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Inflammation influences cancer development and progression, and a low lymphocyte to monocyte ratio (LMR) has been reported to be a poor prognostic indicator in several malignancies. Here we quantify the prognostic impact of this biomarker and assess its consistency in various cancers. Eligible studies were retrieved from PubMed, Embase and Web of Science databases. Overall survival (OS) was the primary outcome, cancer-specific survival (CSS), disease-free survival (DFS), recurrence-free survival (RFS), and progression-free survival (PFS) were secondary outcomes. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Fifty-six studies comprising 20,248 patients were included in the analysis. Overall, decreased LMR was significantly associated with shorter OS in non-hematological malignancy (HR: 0.59, 95% CI: 0.53–0.66; P < 0.001) and hematological malignancy (HR: 0.44, 95% CI: 0.34–0.56; P < 0.001). Similar results were found in CSS, DFS, RFS and PFS. Moreover, low LMR was significantly associated with some clinicopathological characteristics that are indicative of poor prognosis and disease aggressiveness. By these results, we conclude that a decreased LMR implied poor prognosis in patients with cancer and could serve as a readily available and inexpensive biomarker for clinical decision.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

et al. 2016

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“…NLR has been reported to be an independent factor of clinical outcomes in coronary artery disease, and an attractive biomarker for predicting the severity of the lesion, which has potential to be a universal biomarker in clinical applications [17–20]. MLR has been proved to be a prognostic factor in patients with malignancies and tuberculosis [21–24]. However, the role of MLR in CAD is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment

Fan

et al. 2017

BMC Cardiovasc Disord

120

100

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BackgroundWe aimed to explore whether monocyte to lymphocyte ratio (MLR) provides predictive value of the lesion severity in patients with coronary artery disease (CAD).MethodsFive hundred forty-three patients undergoing coronary angiography were analyzed in this retrospective study. Patients with coronary stenosis were divided into three groups on the basis of Syntax score. The control group consisted of patients with normal coronary arteries. MLR was calculated by dividing monocytes count by lymphocytes count obtained from routine blood examination. Multivariate logistic analysis was used to assess risk factors of CAD. Ordinal logistic regression analysis was used to assess the relationship between MLR and the lesion severity of coronary arteries.ResultsMLR was found to be an independent risk factor of the presence of CAD (OR: 3.94, 95% CI: 1.20–12.95) and a predictor of the lesion severity (OR: 2.05, 95% CI: 1.15–3.66). Besides, MLR was positively correlated with Syntax score(r = 0.437, p < 0.001). In the receiver-operating characteristic (ROC) curve analysis, MLR, with an optimal cut-off value of 0.25, predicted the severe coronary lesion with a sensitivity of 60.26% and specificity of 78.49%.ConclusionsMLR was an independent risk factor of the presence of CAD, and a predictor of the lesion severity. Compared to neutrophil to lymphocyte ratio (NLR), MLR has better performance to reflect the severity of coronary lesion.

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Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus‐associated hepatocellular carcinoma patients after curative hepatectomy

Lin

et al. 2016

Journal of Surgical Oncology

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The Preoperative Lymphocyte-to-Monocyte Ratio is Prognostic of Clinical Outcomes for Patients with Liver-Only Colorectal Metastases in the Neoadjuvant Setting

Abstract: This study identified preoperative LMR as an independent prognostic factor for PRS, CSS, and OS but not for DFS in patients undergoing hepatectomy for liver-only colorectal metastases. In the future, interventions to augment immune function could improve survival for low-LMR patients.

Cited by 47 publications

References 26 publications

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Monocyte/lymphocyte ratio predicts the severity of coronary artery disease: a syntax score assessment

Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus‐associated hepatocellular carcinoma patients after curative hepatectomy

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