The preoperative diagnosis of hepatic metastases in cases of colorectal carcinoma

Abstract

Preoperative LDH, CPK, alkaline phosphatase and liver scan results were compared with the presence or absence of hepatic metastases at operation in 124 laparotomies in 123 patients with colorectal carcinomas during a three-year period. The overall accurcy rates for the four tests ranged from 74 to 84 per cent. The false-negative rates were acceptably low (9-13 per cent) for all but the CPK determination. The false-positive rates were unacceptably high for all four tests (38 to 60 per cent). A 'metastatic score' for reducing the high false-positive rate is described. In view of the high false-positive rates of preoperative screening tests, laparotomy is presently the most accurate method of diagnosing hepatic metastases.

Tests for Liver Metastases in Gastrointestinal Cancer

“…[1] 1985 CEA* Christensen and Jacobsen [18] 1987 CEA* Colizza et al [1] 1985 CEA* Jonsson et al [10] 1984 Y-GT Schreve et al [14] 1984 y-g t Huguier et al [11] 1982 y-g t Ranson et al [8] 1973 ASAT Ranson et al [8] 1973 ASAT Schreve et al [14] 1984 ASAT Huguier et al [11] 1982 ASAT Ranson et al [8] 1973 ALAT Ranson et ai. [8] 1973 ALAT Schreve et al [ 14] 1984 AL.AT Ranson et al [8] 1973 LDH Ranson et al [8] 1973 LDH Read et al [9] 1977 LDH Schreve et al [14] 1984 LDH Huguier et al [11] 1982 LDH …”

“…The aim of the present review was to make a status of tests for liver métastasés in [8] 1973 ALP Read et al [9] 1977 ALP Lamb and Taylor [7] 1982 ALP Jonsson et al [10] 1984 ALP Fee et al [ 16] 1974 ALP Schreve et al [14] 1984 ALP Colizza et al [ 1 ] 1985 ALP Huguier et al [11] 1982 ALP* Christensen and Jacobsen [18] 1987 ALP* Christensen and Jacobsen [18] 1987 ALP* Szymendera et al [ 12] 1982 CEA Staab et ai. [15] 1980 CEA Colizza et al [1] 1985 CEA* Christensen and Jacobsen [18] 1987 CEA* Szymendera et al [12] 1982 CEA* Colizza ctal.…”

Current aspects of nuclear imaging in clinical oncology

“…Disorganization of the normal acoustic spatial patterns within the liver may be identified on sonogram. 1, 7 The liver scintigraph provides an accurate method of assessing tumor growth or regression in a patient with known metastatic involvement . t 6 .…”

Quantitative Determination of High Molecular Weight Alkaline Phosphatase in Patients with Colorectal Cancer by Polyacrylamide Gel Electrophoresis

“…This is because none of the 20 control patients has a high molecular weight ALP value exceeding the cutoff line. Although determinations of total ALP were found useful for the detection of he patic métastasés in cases of colorectal cancer [12], they were rather insensitive for primary colorectal cancer detection (20%). On the other hand, a 60% diagnostic sensitivity of high molecular weight ALP revealed the fea-…”