The preoperative C‐reactive protein–lymphocyte ratio and the prognosis of oral cavity squamous cell carcinoma

Ko, Chun-Han; Fang, Ku‐Hao; Hsu, Cheng‐Ming; Lee, Yi-Chan; Chang, Geng‐He; Huang, Eagle Yi‐Kung; Tsai, Ming‐Shao; Tsai, Yao‐Te

doi:10.1002/hed.26738

Cited by 17 publications

(15 citation statements)

References 41 publications

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“…The prognostic role of CLR has been studied in other malignancies, too. According to a study which observed CLR in oral malignancy, elevated level of CLR was associated with better prognostic performance compared to other inflammatory markers in subjects with squamous cell carcinoma 11 . Similarly, Meng et al investigated CLR in patients with colorectal cancer and reported that patients with high CLR had shorter overall survival than those with low CLR levels 12 .…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Demirkol

Aktas

Bilgin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Chronic hepatitis C (CHC) is one of the most important health problems affecting the significant rate of world population and it may lead to cirrhosis and hepatocellular carcinoma. C-reactive protein to lymphocyte count ratio (CLR) is used in estimating inflammatory burden. Therefore, this study aimed to compare CLR values between CHC patients and healthy controls and between CHC patients with and without fibrosis. METHODS: Patients with CHC infection who visited outpatient and inpatient internal medicine clinics of our institution between January 2021 and December 2021 were enrolled to this retrospective study. CLR of the patients with CHC and healthy controls were compared. We further compared CLR of CHC patients with and without fibrosis. RESULTS: Median CLR of CHC and control subjects was 2.61 (5.13%) and 0.31 (0.37%), respectively. CLR of the CHC group was significantly increased compared to the CLR of the controls (p<0.001). There was a significant positive correlation between CLR and APRI score (r=0.15, p=0.04). The sensitivity and specificity of CLR in determining CHC above 0.58% level were 84% and 82%, respectively (AUC: 0.884, p<0.001, 95%CI 0.84-0.93). In subgroup analysis, CLR was 3.97 (6.6%) for CHC patients with fibrosis and 1.7 (4.4%) for CHC subjects without fibrosis (p=0.001). CONCLUSIONS: Increased CLR in patients with CHC may be an alarming finding of liver fibrosis, as CLR is associated with both CHC and hepatic fibrosis.

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Section: Discussionmentioning

confidence: 99%

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Demirkol

Aktas

Bilgin

et al. 2022

Rev. Assoc. Med. Bras.

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“…The widely used AJCC staging system considers only tumor characteristics. However, patient factors such as antitumor immunity, systemic inflammation, and nutritional status are also significantly associated with the survival outcomes of OSCC 12 , 13 , 19 , and not considering these factors when prognosticating may impair the accuracy of survival predictions. Given that CALLY index integrates the peripheral lymphocyte count with serum CRP and albumin levels in an easily calculable manner, we developed a prognostic nomogram incorporating the CALLY index, AJCC stage system, and clinicopathological features to provide individualized 3-year and 5-year OS estimations and favorable results were obtained (C-index: 0.797; AUC: 0.81).…”

Section: Discussionmentioning

confidence: 99%

“…The value of using clinicopathological features as prognostic factors was carefully reviewed; these features were as follows: sex; age at diagnosis; underlying comorbidities according to the Charlson comorbidity index (CCI) 18 ; tumor subsite and size; pathological cancer stage, as defined by the American Joint Committee on Cancer eighth-edition cancer staging manual; ENE and PNI status; cancer cell differentiation; depth of invasion (DOI); nearest surgical margin; the need for and types of adjuvant therapy; and personal health-related habits. Cigarette smoking was defined as smoking ≥1 packet of cigarettes daily for ≥1 year; alcohol drinking was defined as consuming ≥2 alcoholic beverages weekly for more than half a year; and betel nut consumption was defined as chewing ≥3 betel nuts daily for ≥1 year 19 . Each patient was classified as having no, one, and two or all exposures if they had none, one, and two or more of the aforementioned personal habits, respectively.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Oral Cavity Cancer

Tsai¹,

Ko²,

Chen³

et al. 2022

J. Cancer

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Background:The prognostic value of the CRP-albumin-lymphocyte index (CALLY index) was analyzed in patients with oral cavity squamous cell carcinoma (OSCC) undergoing curative surgery. Methods: We retrospectively included 279 patients who were diagnosed as having primary OSCC and being treated with surgery. The optimal cutoff for the preoperative CALLY index was identified by considering the area under the receiver operating characteristic curve; subsequently, the discriminatory ability of the cutoff was determined. We employed Kaplan-Meier analysis and the log-rank test to elucidate associations between the CALLY index and survival outcomes. We identified prognostic variables by using the Cox proportional hazards model. Finally, we devised a nomogram based on the CALLY index for predicting individualized survival. Results: The cutoff value of the CALLY index was determined to be 0.65. A CALLY index < 0.65 exhibited a significant association with pathological aggressiveness as well as shorter overall and disease-free survival (OS and DFS, both P < 0.001). A low CALLY index was an independent risk factor for short OS and DFS [hazard ratio = 3.816; 95% confidence interval (CI) 2.393-6.086; P < 0.001; and hazard ratio = 2.103; 95% CI 1.451-3.049; P < 0.001, respectively] in multivariate Cox analysis. The prognostic nomogram based on the CALLY index yielded accurate predictions of OS, as revealed by a concordance index of 0.797. Conclusions:The preoperative CALLY index is easy and inexpensive to calculate and, in patients with OSCC, can be a valuable prognostic biomarker. The CALLY-index-based nomogram established in this study provides accurate survival predictions.

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“…Two Taiwanese studies observed that a squamous cell carcinoma antigen level of 2.0 ng/ml and a CRP level of 5.0 mg/L were associated with the prognosis of OSCC ( 32 ) and pharyngolaryngeal carcinoma ( 33 ). Ko et al reported that the preoperative CRP–lymphocyte ratio was related to the prognosis of patients with OSCC ( 34 ). The CRP/albumin ratio could predict poor survival in patients with hypopharyngeal and laryngeal cancer ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma

Zhang

2022

Front. Oncol.

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ObjectiveThis study evaluated the association of pretreatment serum C-reactive protein (CRP) level with prognosis in patients with head and neck squamous cell carcinoma (HNSCC).MethodsWithin a single-center retrospective study, HNSCC patients receiving treatment between 2014 and 2016 were analyzed regarding the prognostic value of CRP serum levels. X-Tile software was used to determine the optimal cutoff value of serum CRP level. The log-rank test and Kaplan–Meier method were used to assess the effects of CRP level on prognosis in patients with HNSCC. Univariate and multivariate analyses (enter method) using a Cox proportional hazards model were utilized to identify prognostic indicators of progression-free survival (PFS) as the primary outcome and overall survival (OS) as the secondary outcome.ResultsA total of 221 patients with HNSCC were assessed for eligibility, and 208 cases were included in the analysis. The HNSCC patients in the low-group (CRP ≤11.3 mg/L) showed better survival than those in the high-group (CRP > 11.3 mg/L). The univariate and multivariate analyses showed that N1-3 stage and a high serum CRP level (>11.3 mg/L) were unfavorable prognostic factors for PFS and OS in patients with HNSCC.ConclusionSerum CRP level is an independent prognostic marker for patients with HNSCC. CRP level could be regarded as a novel prognostic factor for HNSCC patients.

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The preoperative C‐reactive protein–lymphocyte ratio and the prognosis of oral cavity squamous cell carcinoma

Cited by 17 publications

References 41 publications

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Oral Cavity Cancer

Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma

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