The Prenatal Expression of Secretin Receptor

Siu, Francis K.Y.; Sham, Mai Har; Chow, Billy K. C.

doi:10.1196/annals.1317.081

Cited by 14 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 Moreover, secretin and secretin receptor are located in the developing fetal regions. 9,39 Thus, it is very likely that secretin acts either on placentogenesis or on tissues of the developing fetus. Secretin and secretin receptor-deficient mice have been generated, respectively.…”

Section: Possible Function Of Secretin During Decidualizationmentioning

confidence: 99%

Progesterone Regulates Secretin Expression in Mouse Uterus During Early Pregnancy

Huang

Wang

et al. 2014

Reprod. Sci.

View full text Add to dashboard Cite

Secretin, a classical gastrointestinal and neuroendocrine peptide, plays an important role in maintaining the body fluid balance. However, the expression and regulation of secretin in the reproductive system are still unknown. In our study, secretin is specifically expressed in the decidua on days 5 to 8 of pregnancy. Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization. Progesterone induces secretin expression in ovariectomized mice and cultured stromal cells, which is abrogated by specific LY294002. Because secretin is mainly localized in the decidua and also strongly expressed during in vitro decidualization, secretin may play a role during mouse decidualization through regulating cyclic adenosine monophosphate level.

show abstract

Section: Possible Function Of Secretin During Decidualizationmentioning

confidence: 99%

Progesterone Regulates Secretin Expression in Mouse Uterus During Early Pregnancy

Huang

Wang

et al. 2014

Reprod. Sci.

View full text Add to dashboard Cite

show abstract

“…In addition to the SCT immunoreactivity found in rat and pig brain extracts (O'Donohue et al, 1981), the expression of SCT and its receptor (SCTR) have also been detected in various brain regions, including the cortex, hippocampus, hypothalamus, and brainstem (Ng et al, 2002) across multiple developmental stages (Siu et al, 2005(Siu et al, , 2006, leading to the hypothesis of a putative neuropeptide role for SCT. Our research group previously used SCT and SCTR knockout mouse models to demonstrate the endogenous release of SCT in the hypothalamus (Chu et al, 2006) and examine related central mechanisms in the regulation of water homeostasis (Chu et al, 2007;Chu et al, 2009;Lee et al, 2010) and food intake (Cheng et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The Knockout of Secretin in Cerebellar Purkinje Cells Impairs Mouse Motor Coordination and Motor Learning

Zhang

Chung

Chow

2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Secretin (SCT) was first considered to be a gut hormone regulating gastrointestinal functions when discovered. Recently, however, central actions of SCT have drawn intense research interest and are supported by the broad distribution of SCT in specific neuronal populations and by in vivo physiological studies regarding its role in water homeostasis and food intake. The direct action of SCT on a central neuron was first discovered in cerebellar Purkinje cells in which SCT from cerebellar Purkinje cells was found to potentiate GABAergic inhibitory transmission from presynaptic basket cells. Because Purkinje neurons have a major role in motor coordination and learning functions, we hypothesize a behavioral modulatory function for SCT. In this study, we successfully generated a mouse model in which the SCT gene was deleted specifically in Purkinje cells. This mouse line was tested together with SCT knockout and SCT receptor knockout mice in a full battery of behavioral tasks. We found that the knockout of SCT in Purkinje neurons did not affect general motor ability or the anxiety level in open field tests. However, knockout mice did exhibit impairments in neuromuscular strength, motor coordination, and motor learning abilities, as shown by wire hanging, vertical climbing, and rotarod tests. In addition, SCT knockout in Purkinje cells possibly led to the delayed development of motor neurons, as supported by the later occurrence of key neural reflexes. In summary, our data suggest a role in motor coordination and motor learning for SCT expressed in cerebellar Purkinje cells.

show abstract

“…In adult brains, SCT and SCTR were: (1) expressed in hindlimb area of cerebral motor cortex and prominently distributed in hippocampus; (2) abundantly found in thalamus and hypothalamus; (3) not present in midbrains except for embryos; and (4) widely distributed in hindbrain regions including cerebellum and medulla oblongata. During embryonic development, transcripts and proteins of SCT and transcripts of SCTR were found in cerebellar primordium, tegmentum, and mesenchyme flexure as early as embryonic day 10.5 (5, 6). As these SCT- or SCTR-expressing neurons control unique behaviors (i.e., hippocampus: learning and memory; hypothalamus: sex, drinking, and feeding; cerebellum: motor coordination and motor learning), it was postulated that SCT had a role in multiple behaviors.…”

Section: Introductionmentioning

confidence: 99%

“… a SCT peptide was found in pyramidal cells in cerebral cortex from humans, and colchicine-treated rats (7) but with less (11) or no forebrain expression (18) in untreated rats . b SCT and SCTR gene expression was detected by staining the lacZ reporter . c SCT and SCTR expression was found in embryonic mesencephalic neurons until birth (5, 6) but not in adults (16) . All these cell-specific expression profiles have been reported previously using IHC (for peptide) or ISH staining (for gene expression) in intact rodents, unless otherwise specified . DG, dentate gyrus; SON, supraoptic nucleus; PVN, paraventricular nucleus; Arc, arcuate nucleus; CVO, circumventricular organ; SFO, subfornical organ; OVLT, organum vasculosum of lamina terminalis; NSE, no significant expression; DCN, deep cerebellar nucleus; NTS, nucleus tractus solitarius .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Central Mechanisms of Secretin in Regulating Multiple Behaviors

Zhang

Chow

2014

Front. Endocrinol.

View full text Add to dashboard Cite

Secretin (SCT) was firstly discovered as a gut peptide hormone in stimulating pancreatic secretion, while its novel neuropeptide role has drawn substantial research interests in recent years. SCT and its receptor (SCTR) are widely expressed in different brain regions, where they exert multiple cellular functions including neurotransmission, gene expression regulation, neurogenesis, and neural protection. As all these neural functions ultimately can affect behaviors, it is hypothesized that SCT controls multiple behavioral paradigms. Current findings support this hypothesis as SCT–SCTR axis participates in modulating social interaction, spatial learning, water and food intake, motor coordination, and motor learning behaviors. This mini-review focuses on various aspects of SCT and SCTR in hippocampus, hypothalamus, and cerebellum including distribution profiles, cellular functions, and behavioral phenotypes to elucidate the link between cellular mechanisms and behavioral control.

show abstract

The Prenatal Expression of Secretin Receptor

Cited by 14 publications

References 16 publications

Progesterone Regulates Secretin Expression in Mouse Uterus During Early Pregnancy

Progesterone Regulates Secretin Expression in Mouse Uterus During Early Pregnancy

The Knockout of Secretin in Cerebellar Purkinje Cells Impairs Mouse Motor Coordination and Motor Learning

The Central Mechanisms of Secretin in Regulating Multiple Behaviors

Contact Info

Product

Resources

About