An opportunity recently arose to treat in utero, with the aid of real-time ultrasound, a fetus affected with urinary outflow tract obstruction. This report documents that attempt at treatment and elucidates the constituents of fetal urine obtained at various gestational ages.
CASE REPORTA 22-yr-old woman, gravida 2, para 0, abortion 1, with a last menstrual period of 6/22/80 and an EDC of 3/29/81 had an uncomplicated prenatal course until 26 wk gestation, when an ultrasound examination was performed because of a sizedate discrepancy. Findings at this examination revealed a single fetus in the vertex presentation, a biparietal diameter of 63 mm (26 wk gestation), normal amniotic fluid volume, bilateral hydronephrosis, and a large cystic abdominal mass displacing the bowel superiorly and laterally (Fig 1). The abdominal wall was quite thin. The presumptive diagnosis was urinary outflow tract obstruction and prune belly syndrome. To prevent potential damage to the renal and pulmonary systems, it was thought that the pressure of the distended bladder should be relieved.With continuous guidance by real-time ultrasound, direct placement of a 20-gauge spinal needle into the fetal bladder was performed and 340 ml of fetal urine was removed. The bladder drainage was repeated one week later, with removal of 310 ml of fetal urine. Seven days later, fetal ascites was noted, and the bladder was less distended (Fig 2). Fetal ascitic fluid was removed totaling 320 ml, and 50 ml of fetal urine was also