The preload recruitable stroke work relationship as a measure of left ventricular contractile dysfunction in porcine cardiac allografts

Ryan, Jonathon B.; Hicks, Mark; Cropper, Jonathan R.; Garlick, Sarah; Kesteven, Scott; Wilson, Michael K.; Macdonald, P.; Feneley, Michael P.

doi:10.1016/s1010-7940(02)00526-2

Cited by 20 publications

(31 citation statements)

References 20 publications

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“…Importantly, the preload recruitable stroke work relationship is a sensitive measure of porcine allograft left ventricular functional recovery after orthotopic transplantation. 22 The decrease of preload recruitable stroke work was attenuated in the allografts from donors treated with HTS, indicating beneficial effects on left ventricular recovery. Furthermore, the ability to wean from cardiopulmonary bypass was significantly greater in the donor HTS-treated group compared with control.…”

Section: Enhanced Allograft Functional Recoverymentioning

confidence: 93%

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

et al. 2009

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Background-Hypertonic saline (HTS) has been previously demonstrated to have immune modulatory and vascular protective effects. We assessed the effect of donor pretreatment with HTS on allograft preservation in a porcine model of orthotopic heart transplantation. Methods and Results-Orthotopic transplants were performed after 6 hours of cold static allograft storage. Donor pigs were randomly assigned to pretreatment with (nϭ7) or without (nϭ6) HTS (4.5 mL/kg of 7.5% NaCl) administered 1 hour before donor heart arrest. Administration of HTS increased serum sodium level from 138Ϯ2 mmol/L to 154Ϯ4 mmol/L, which normalized to 144Ϯ3 mmol/L 1 hour after infusion. Successful weaning from cardiopulmonary bypass was significantly greater in HTS-treated hearts (6/7 vs 1/6; Pϭ0.029).

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Section: Enhanced Allograft Functional Recoverymentioning

confidence: 93%

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

et al. 2009

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“…The significance of differences in the PRSW relationship was determined using a multiple linear regression (MLR) implementation of two-way analysis of covariance with repeated measures (30). To reduce potential confounders, LVV epi and SW were normalized within individual animals to their baseline steady state values.…”

Section: Discussionmentioning

confidence: 99%

“…A porcine model of the brain-dead organ donor which closely mimics the deceased human donor was used, as previously described (30). This model was approved by our animal ethics committee and was utilized in accordance with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes (31).…”

Section: Methodsmentioning

confidence: 99%

“…The prolate ellipsoid model was used to calculate epicardial left ventricular volume (LVV epi ) from the cardiac dimension data (LVV epi =p a.b 2 /6, where a = major axis length and b = minor axis length) and pressure-volume (PV) loops were derived ( Figure 1) (30). Stroke work (SW) was calculated as the PV loop area for each heart beat.…”

Section: Data Acquisition and Analysismentioning

confidence: 99%

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The Effects of Hormone Resuscitation on Cardiac Function and Hemodynamics in a Porcine Brain-Dead Organ Donor Model

Hing

Hicks

Garlick

et al. 2007

American Journal of Transplantation

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We compared the effects of hormone resuscitation (HR) with a norepinephrine-based protocol on cardiac function, hemodynamics and need for vasopressor support after brain death in a porcine model. Following brain death induction, animals were treated with norepinephrine and fluids for 3 h. In the following 3 h, they continued on norepinephrine and fluids (control) or received additional HR (triiodothyronine, methylprednisolone, vasopressin, insulin). Data were collected pre-brain death, 3 and 6 h post-brain death. At 6 h, median norepinephrine use was higher in controls (0.563 vs. 0 lg/kg/min; p < 0.005), with 6/8 HR animals weaned off norepinephrine compared with 0/9 controls. Mean arterial pressure was higher in HR animals at 6 h (74 ± 17 vs. 54 ± 14 mmHg; p < 0.05). Cardiac contractility was also significantly higher in HR animals at 6 h (stroke work index 1.777 vs. 1.494). After collection of 6 h data, all animals were placed on the same low dose of norepinephrine. At 6.25 h, HR animals had higher stroke work (3540 ± 1083 vs. 1536 ± 702 mL.mmHg; p < 0.005), stroke volume (37.2 ± 8.2 vs. 21.5 ± 9.8 mL; p < 0.01) and cardiac output (5.8 ± 1.4 vs. 3.2 ± 1.2 L/min; p < 0.005). HR in a porcine model of brain death reduces norepinephrine requirements, and improves hemodynamics and cardiac function. These results support the use of HR in the management of the brain-dead donor.

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“…A porcine model of orthotopic heart transplantation incorporating donor brain death and hypothermic ischemic preservation was used (12)(13)(14). All (15).…”

Section: Methodsmentioning

confidence: 99%

Combining Cariporide with Glyceryl Trinitrate Optimizes Cardiac Preservation During Porcine Heart Transplantation

Hing

Watson

Hicks

et al. 2009

American Journal of Transplantation

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Sodium-hydrogen exchange inhibitors, such as cariporide, are potent cardioprotective agents, however, safety concerns have been raised about intravenously (i.v.) administered cariporide in humans. The aim of this study was to develop a preservation strategy that maintained cariporide's cardioprotective efficacy during heart transplantation while minimizing recipient exposure. We utilized a porcine model of orthotopic heart transplantation that incorporated donor brain death and 14 h static heart storage. Five groups were studied: control (CON), hearts stored in Celsior; CAR1, hearts stored in Celsior with donors and recipients receiving cariporide (2 mg/kg i.v.) prior to explantation and reperfusion, respectively; CAR2, hearts stored in Celsior supplemented with cariporide (10 lmol/L); GTN, hearts stored in Celsior supplemented with glyceryl trinitrate (GTN) (100 mg/L); and COMB, hearts stored in Celsior supplemented with cariporide (10 lmol/L) plus GTN (100 mg/L). A total of 5/5 CAR1 and 5/6 COMB recipients were weaned from cardiopulmonary bypass compared with 1/5 CON, 1/5 CAR2 and 0/5 GTN animals (p = 0.001). Hearts from the CAR1 and COMB groups demonstrated similar cardiac function and troponin release after transplantation. Supplementation of Celsior with cariporide plus GTN provided superior donor heart preservation to supplementation with either agent alone and equivalent preservation to that observed with systemic administration of cariporide to the donor and recipient.

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The preload recruitable stroke work relationship as a measure of left ventricular contractile dysfunction in porcine cardiac allografts

Cited by 20 publications

References 20 publications

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

The Effects of Hormone Resuscitation on Cardiac Function and Hemodynamics in a Porcine Brain-Dead Organ Donor Model

Combining Cariporide with Glyceryl Trinitrate Optimizes Cardiac Preservation During Porcine Heart Transplantation

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