The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinoma in Gabonese women

Assoumou, Samira Zoa; Boumba, Anicet Luc Magloire; Ndjoyi-Mbiguino, Angélique; Khattabi, Abdelkrim; Ennaji, Moulay Mustapha

doi:10.1007/s12032-014-0281-4

Cited by 13 publications

(4 citation statements)

References 31 publications

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“…Some studies claimed that this SNP is a risk factor for oral cancer while other studies detected no effect in oral carcinogenesis, showing clear discrepancy between results across the world. The different patterns noticed in allelic distribution and genotypic frequencies of this polymorphism may be due to variations in methodological approaches, sample size, laboratory performance, DNA quality and source, variation in ethnic background or environmental exposures of study populations [16,32,33].…”

Section: Discussionmentioning

confidence: 99%

Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis

Pd¹,

Sa²,

Touré³

et al. 2020

jmgm

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Background: The loss of function in TP53 gene is an early event of carcinogenesis and is now considered as a full etiological factor in oral squamous cell carcinoma (OSCC). The most common polymorphism in this gene that is associated to OSCC and has been extensively studied as a potential risk factor for the development of malignancies is the single nucleotide polymorphism (SNP) encoding either proline or arginine at residue 72. Today, despite the multiplicity of publications and approaches used, the contradiction of the results have not remove the ambiguity of the possible impact of this polymorphism in OSCC. So we aimed this meta-analysis to investigate the distribution of TP53 codon 72 genotypes and alleles in patients with OSCC and healthy matched controls, by using an ethnicity subgroups analysis. Method: A literature search was conducted to identify studies concerning TP53 codon 72 polymorphism and OSCC risk. Retrieved publications from 2000 to 2014 were classified by ethnicity, according to the sampling collection continent. Allelic frequencies were estimated by using genotypic data and Hardy-Weinberg Equilibrium and distributions were checked with Chi-2 test. Statistical tests for contrast models of association were performed with Proline allele as reference stratum. Results: Arg allele distribution was almost similar in both cases and controls for African and Caucasian populations whereas Arg frequency was significantly greater in cases than in controls for Asians (p=0.011). After stratified statistical analyses, we've found again a significant association between Arginine allele and OSCC risk in the Asian subgroup (OR=1.31; 95% CI=1.09-1.58; P=0.004). Conclusion: This current study revealed that allelic distribution of TP53 Arg72Pro polymorphism may depend on ethnicity and latitude, and highlighted that Arginine carrier in Asian populations may be considered to be predisposed to OSCC.

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Section: Discussionmentioning

confidence: 99%

Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis

Pd¹,

Sa²,

Touré³

et al. 2020

jmgm

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“…Additional studies also reported the potential roles of common gene variants that are involved in the cellular cycle and apoptosis, cell proliferation and differentiation, DNA repair, and immune responses [40][41][42][43][44][45][46]. Nevertheless, as in many other association analyses, evidence of how genetic susceptibility is linked mechanistically to the progression of cervical cancer is still lacking.…”

Section: Key Factors That Contribute To Hpv Persistence and Cervical mentioning

confidence: 99%

The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications

2018

Cancer Medicine

246

140

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Cervical cancer is the third most common cancer in women worldwide, with concepts and knowledge about its prevention and treatment evolving rapidly. Human papillomavirus (HPV) has been identified as a major factor that leads to cervical cancer, although HPV infection alone cannot cause the disease. In fact, HPV‐driven cancer is a small probability event because most infections are transient and could be cleared spontaneously by host immune system. With persistent HPV infection, decades are required for progression to cervical cancer. Therefore, this long time window provides golden opportunity for clinical intervention, and the fundament here is to elucidate the carcinogenic pattern and applicable targets during HPV‐host interaction. In this review, we discuss the key factors that contribute to the persistence of HPV and cervical carcinogenesis, emerging new concepts and technologies for cancer interventions, and more urgently, how these concepts and technologies might lead to clinical precision medicine which could provide prediction, prevention, and early treatment for patients.

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“…Previous studies have investigated this association in the SSA, and the results reported thus far have been inconclusive [16‐25]. The inconclusive findings may be due to the small sample sizes, which reduce the statistical power of these studies to detect a small genetic effect.…”

Section: Introductionmentioning

confidence: 99%

Association of TP53 rs1042522 with cervical cancer in the sub‐Saharan African population: a meta‐analysis

Kamiza

Singini

et al. 2020

Tropical Med Int Health

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objective TP53 plays a crucial role in preventing cancer development. Previous studies in sub-Saharan Africa (SSA) reported inconclusive findings for the association of the TP53 rs1042522 C > G variant with cervical cancer. We therefore performed a meta-analysis to summarise this association in the SSA population.methods Online databases were searched to identify suitable articles according to the PRISMA guidelines. We included studies published in English or French that provided the sample sizes and genotype counts for both cases and controls and evaluated the association between TP53 rs1042522 and cervical cancer in the SSA population. A fixed-effect model was used to calculate the pooled odds ratio (OR) and 95% confidence intervals (95% CIs).results A total of 699 cervical cancer cases and 1008 controls from eight studies in SSA were included in this meta-analysis. Women harbouring the variant G allele of the TP53 rs1042522 were at increased risk of cervical cancer in allelic (G vs. C; OR = 1.30, 95% Cl = 1.12-1.50), homozygous (GG vs. CC; OR = 1.62, 95% CI = 1.20-2.19) and recessive (GG vs. CG + GG; OR = 1.74, 95% CI = 1.34-2.25) genetic models. However, the dominant genetic model (CG + GG vs. CC; OR = 1.20, 95% CI = 0.96-1.48) was not significantly associated with cervical cancer.conclusions Our meta-analysis revealed that harbouring variant G allele of TP53 rs1042522 is associated with cervical cancer risk in the SSA population.keywords cervical cancer, TP53 rs1042522, polymorphism, sub-Saharan Africa, meta-analysis Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 17 (partnerships for the goals)

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The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinoma in Gabonese women

Cited by 13 publications

References 31 publications

Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis

Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis

The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications

Association of TP53 rs1042522 with cervical cancer in the sub‐Saharan African population: a meta‐analysis

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