The pregnancy-induced increase of plasma angiotensin-(1–7) is blunted in gestational diabetes

Nogueira, Anelise I; Santos, Robson A.S.; Silva, Ana Cristina Simões e; Cabral, Antônio Carlos Vieira; Vieira, R.; Drumond, Thaís C.; Machado, Lucas José de Campos; Freire, Cláudia Maria Vilas; Ribeiro‐Oliveira, Antônio

doi:10.1016/j.regpep.2006.12.014

Cited by 41 publications

(33 citation statements)

References 31 publications

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“…Ang-(1-7) is a vasodilator, in part due to its recently demonstrated capability of activating the endothelial nitric oxide synthase (40) and also because of its proven ability to potentiate the action of bradykinin (26). Gestational diabetes is associated with decreased levels of Ang-(1-7), which coincides with endothelial dysfunction during pregnancy (35). This agrees with the beneficial effects (vasodilation, improvement of glucose, and lipid metabolism) exerted by Ang- (1-7).…”

Section: Discussionmentioning

confidence: 99%

Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats

Giani¹,

Mayer²,

Muñoz³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

153

110

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Section: Discussionmentioning

confidence: 99%

Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats

Giani¹,

Mayer²,

Muñoz³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

153

110

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“…Ang-(1-7) has been associated to the physiopathology of several diseases such as hypertension, preeclampsia, hypertrophic myocardial disease and CHF, MI, chronic renal diseases, diabetic nephropathy, GDM and cirrhosis (62,63). Further studies should try to better elucidate the role of Ang- (1-7), as opposed to Ang II, in diabetes.…”

Section: Pathophysiologymentioning

confidence: 99%

Is there a link between glucose levels and heart failure? An update

Schainberg¹,

Ribeiro‐Oliveira

Ribeiro³

2010

Arq Bras Endocrinol Metab

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SUMMARYIt has been well documented that there is an increased prevalence of standard cardiovascular (CV) risk factors in association with diabetes and with diabetes-related abnormalities. Hyperglycemia, in particular, also plays an important role. Heart failure (HF) has become a frequent manifestation of cardiovascular disease (CVD) among individuals with diabetes mellitus. Epidemiological studies suggest that the effect of hyperglycemia on HF risk is independent of other known risk factors. Analysis of datasets from populations including individuals with dysglycemia suggests the pathogenic role of hyperglycemia on left ventricular function and on the natural history of HF. Despite substantial epidemiological evidence of the relationship between diabetes and HF, data from available interventional trials assessing the effect of a glucose-lowering strategy on CV outcomes are limited. To provide some insight into these issues, we describe in this review the recent important data to understand the natural course of CV disease in diabetic individuals and the role of hyperglycemia at different times in the progression of HF. Arq Bras Endocrinol Metab. 2010;54(5):488-97 Keywords Prediabetic state; blood glucose; hyperglycemia; ventricular dysfunction, left; heart failure SUMÁRIO Já foi bem documentado um aumento da prevalência dos fatores de risco cardiovascular convencional em portadores de diabetes melito e em pessoas com as anormalidades relacionadas ao diabetes. A hiperglicemia, particularmente, teria um papel crítico. A insuficiência cardíaca (IC) tem se tornado uma manifestação frequente da doença cardiovascular em indivíduos com diabetes. Estudos epidemiológicos sugerem que o efeito da hiperglicemia no risco para IC é independente dos outros fatores de risco. A análise dos dados de populações que incluem indivíduos com disglicemia sugere um papel patogênico da hiperglicemia na função do ventrículo esquerdo na história natural da IC. A despeito de evidências epidemiológicas na relação entre diabetes e IC, os dados disponíveis de estudos clínicos de intervenção para avaliar o efeito da estratégia de redução da glicose sobre os desfechos cardiovasculares ainda são limitados. Para trazer alguma compreensão nesse tópico, descrevemos nesta revisão os dados recentes e importantes para entender a história natural da doença cardiovascular em indivíduos com diabetes e o papel da hiperglicemia em diferentes períodos na progressão da doença. Arq Bras Endocrinol Metab. 2010;54(5):488-97 Descritores

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“…Our data suggest that a possible therapeutic approach for advanced human cirrhosis could be the combination of AT1 receptor blockers or ACE inhibitors Ratios between angiotensins, especially the relationship between Ang-(1-7) and Ang Ⅱ, have been used to estimate the final functional RAS effect [2,3,4] . In this study, propranolol use was not able to change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation of non-compensated cirrhotic patients, although there was an absolute decrease in both angiotensins.…”

Section: Applicationsmentioning

confidence: 99%

“…The ACE2-Ang-(1-7)-Mas arm mainly acts as a counter-regulatory mechanism for the vasoconstrictor arm [1] . According to this novel concept, the final functional effect of the RAS may reflect a balance between these two arms [2][3][4][5] . This novel view of the RAS makes the evaluation of this system in cirrhosis particularly challenging.…”

Section: Introductionmentioning

confidence: 99%

Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients

Vilas-Boas

Ribeiro‐Oliveira²,

Ribeiro³

et al. 2008

WJG

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AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS: Patients were al located into two groups: outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA), Angiotensin(Ang) Ⅰ, Ang Ⅱ, and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation, hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components. RESULTS:PRA, Ang Ⅰ, Ang Ⅱ and Ang-(1-7) were significantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were s igni f ic a nt ly inc re a s e d in LD gro up re c e i v i n g propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade, whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation, cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION: In LD group, propranolol treatment reduced RAS mediators, but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore, the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. Vilas-Boas WW, Ribeiro-Oliveira Jr A, Cunha Ribeiro R, Vieira RLP, Almeida J, Nadu AP, Simões e Silva AC, Santos RAS. Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients.

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The pregnancy-induced increase of plasma angiotensin-(1–7) is blunted in gestational diabetes

Cited by 41 publications

References 31 publications

Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats

Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats

Is there a link between glucose levels and heart failure? An update

Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients

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