The prefrontal dysfunction in individuals with Internet gaming disorder: a meta‐analysis of functional magnetic resonance imaging studies

Meng, Yajing; Deng, Wei; Wang, Huiyao; Guo, Wanjun; Li, Tao

doi:10.1111/adb.12154

Cited by 171 publications

(109 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a metaanalysis of ten voxel-wise whole-brain fMRI studies, using a variety of cognitive challenge paradigms (mainly focusing on aspects of inhibitory control and flexible responding), internet gaming disorder was associated with excess activation, compared to controls, in the bilateral medial frontral gyrus, left cingulate gyrus, left medial temporal gyrus, and fusiform gyrus (Meng et al 2014a). In a relatively small resting state fMRI study, internet addiction was associated with reduced functional connectivity versus controls across distributed neural circuitry, particularly implicating the bilateral dorsal striatum (putamen), and connections between cortical and subcortical regions (Hong et al 2013).…”

Section: Neurobiology Of Internet Addictionmentioning

confidence: 99%

Behavioural addiction—A rising tide?

Chamberlain

Löchner

Stein

et al. 2016

European Neuropsychopharmacology

View full text Add to dashboard Cite

The term 'addiction' was traditionally used in relation to centrally active substances, such as cocaine, alcohol, or nicotine. Addiction is not a unitary construct but rather incorporates a number of features, such as repetitive engagement in behaviours that are rewarding (at least initially), loss of control (spiralling engagement over time), persistence despite untoward functional consequences, and physical dependence (evidenced by withdrawal symptoms when intake of the substance diminishes). It has been suggested that certain psychiatric disorders characterized by maladaptive, repetitive behaviours share parallels with substance addiction and therefore represent 'behavioural addictions'. This perspective has influenced the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), which now has a category 'Substance Related and Addictive Disorders', including gambling disorder. Could other disorders characterised by repetitive behaviours, besides gambling disorder, also be considered 'addictions'? Potential examples include kleptomania, compulsive sexual behaviour, 'Internet addiction', trichotillomania (hair pulling disorder), and skin-picking disorder. This paper seeks to define what is meant by 'behavioural addiction', and critically considers the evidence for and against this conceptualisation in respect of the above conditions, from perspectives of aetiology, phenomenology, co-morbidity, neurobiology, and treatment. Research in this area has important implications for future diagnostic classification systems, neurobiological models, and novel treatment directions.

show abstract

Section: Neurobiology Of Internet Addictionmentioning

confidence: 99%

Behavioural addiction—A rising tide?

Chamberlain

Löchner

Stein

et al. 2016

European Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Another research showed that IAD had a decreased gray matter volume in the rostral ACC (Yuan et al, 2011). Greater activity in the ACC was also revealed for the interference condition of the stroop paradigm (Dong et al, 2012b) and a meta-analysis showed that IAD had a significant hyperactivation in medial frontal/ACC (Meng et al, 2014). Subjects with IAD also demonstrated an impaired error monitoring ability compared to controls, which was related with the stronger activity in dorsal ACC in error responses (Dong et al, 2013a).…”

Section: Discussionmentioning

confidence: 94%

Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder

Lin

Zhou

et al. 2015

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Abnormal structure and function in the striatum and prefrontal cortex (PFC) have been revealed in Internet addiction disorder (IAD). However, little is known about alterations of corticostriatal functional circuits in IAD. The aim of this study was to investigate the integrity of corticostriatal functional circuits and their relations to neuropsychological measures in IAD by resting-state functional connectivity (FC). Fourteen IAD adolescents and 15 healthy controls underwent resting-state fMRI scans. Using six predefined bilateral striatal regions-of-interest, voxel-wise correlation maps were computed and compared between groups. Relationships between alterations of corticostriatal connectivity and clinical measurements were examined in the IAD group. Compared to controls, IAD subjects exhibited reduced connectivity between the inferior ventral striatum and bilateral caudate head, subgenual anterior cingulate cortex (ACC), and posterior cingulate cortex, and between the superior ventral striatum and bilateral dorsal/rostral ACC, ventral anterior thalamus, and putamen/pallidum/insula/inferior frontal gyrus (IFG), and between the dorsal caudate and dorsal/rostral ACC, thalamus, and IFG, and between the left ventral rostral putamen and right IFG. IAD subjects also showed increased connectivity between the left dorsal caudal putamen and bilateral caudal cigulate motor area. Moreover, altered cotricostriatal functional circuits were significantly correlated with neuropsychological measures. This study directly provides evidence that IAD is associated with alterations of corticostriatal functional circuits involved in the affective and motivation processing, and cognitive control. These findings emphasize that functional connections in the corticostriatal circuits are modulated by affective/motivational/cognitive states and further suggest that IAD may have abnormalities of such modulation in this network.

show abstract

“…More recently, several reviews have focused on the latest neurobiological findings concerning IGD and have summarized important findings (e.g., 64,77,[78][79][80].…”

Section: Developments In Neurobiological Researchmentioning

confidence: 99%

Assessment of internet gaming disorder in clinical research: Past and present perspectives

Pontes

Griffiths

2014

Clinical Research and Regulatory Affairs

View full text Add to dashboard Cite

Internet Gaming Disorder [IGD] has recently received nomenclatural recognition from official medical bodies as a potential mental health disorder, despite evident variability and inconsistencies in its core conceptualization and psychometric assessment. In the present review, the authors argue how the adoption of inconsistent criteria and psychometric tools to assess IGD negatively influenced the field. Additionally, this review provides an overview of how the field evolved in terms of its historical developments, present definitions and frameworks, developments in the neuroscientific research, psychometric assessment, and emerging trends in the assessment of gaming addiction. After a careful review of the literature, it was concluded that (i) research on gaming addiction dates back to the 1970 and since then important changes in the field occurred, especially in terms of (ii) definition and conceptualization of the phenomenon, which resulted in a (iii) multiplicity of strategies in the assessment of IGD via inconsistent criteria or psychometric tools. Lastly, it is presented (iv) alternative emerging methods for assessing IGD via sound psychometric tools based on updated and officially recognized conceptualization of the phenomenon of IGD.

show abstract

The prefrontal dysfunction in individuals with Internet gaming disorder: a meta‐analysis of functional magnetic resonance imaging studies

Cited by 171 publications

References 55 publications

Behavioural addiction—A rising tide?

Behavioural addiction—A rising tide?

Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder

Assessment of internet gaming disorder in clinical research: Past and present perspectives

Contact Info

Product

Resources

About