The Preferred Locations of Meningioma According to Different Biological Characteristics Based on Voxel-Wise Analysis

Abstract

Objective: Meningiomas presented preferred intracranial distribution, which may reflect potential biological natures. This study aimed to analyze the preferred locations of meningioma according to different biological characteristics. Method: A total of 1,107 patients pathologically diagnosed with meningiomas between January 2012 and December 2016 were retrospectively analyzed. Preoperative MRI were normalized, and lesions were semiautomatically segmented. The stereospecific frequency and p value heatmaps were constructed to compare two biological phenotypes using two-tailed Fisher's exact test. Age, sex, WHO grades, extent of resection (EOR), recurrence, and immunohistochemical markers including p53, Ki67, epithelial membrane antigen (EMA), progesterone receptor (PR), and CD34 were statistically analyzed. Recurrence-free survival (RFS) were analyzed by Kaplan-Meier method. Result: Of 1,107 cases, convexity (20.8%), parasagittal (16.1%), and falx (11.4%) were the most predominant loci of meningiomas. The p-value heatmap suggested lesion predominance in the left frontal and occipital convexity among older patients while in the left sphenoid wing, and right falx, parasellar/cavernous sinus, and middle fossa among younger patients. Lesions located at anterior fossa and frontal structures were more frequently seen in the male while left parietal falx and tentorial regions, and right cerebellopontine angle in the female. Grades II and III lesions presented predominance in the frontal structures compared with grade I ones. Meningiomas at the left parasagittal sinus and falx, tentorium, intraventricular regions, and skullbase structures were significantly to receive subtotal resection. Lesions with p53 positivity were statistically located at the left frontal regions and parasellar/cavernous sinus, higher Ki67 index at the left frontal and bilateral parietal convexity and right parasellar/cavernous sinus, EMA negativity at the right olfactory groove and left middle fossa, and CD34 positivity at the sellar regions and right sphenoid wing. Tumor recurrence rates for grades I, II, and III were 2.8, 7.9, and 53.8%, respectively. Inferior RFS, higher Sun et al. The Preferred Locations of Meningioma Ki67 index, grades II and III, and a larger preoperative volume were observed in older patients. Recurrent meningiomas were more frequently found at the occipital convexity, tentorium, sellar regions, parasagittal sinus, and left sphenoid wing. Conclusion: The preferred locations of meningioma could be observed according to different biological characteristics, which might be helpful for clinical decisions.

Are there Predilection Sites for Intracranial Meningioma? A Population-Based Atlas

“…In contrast to some studies where high grade meningiomas more frequently were found over the convexity [11,23,33,42] and non-skull base regions [18,39], we found no such association between WHO grade and tumor locations. In our population based selection the overall median tumor volume was 6.1 cm 3 (mean 16.8 cm 3 ), which is somewhat larger than in reports of incidentally discovered and surgically treated meningiomas [12,27,8,23].…”

Characterization of Progesterone Receptor Expression in Intracranial Meningiomas of Patients Treated in a High-Complexity Hospital in Bogota, Colombia

“…We found a higher frequency in females, with a female-male ratio of 3:1 to 2:1, slightly higher than other studies [2,[4][5]. We also found that meningiomas are more frequent in the supratentorial compartment, with about 90% of occurrences, especially in the lateral skull, which has been a constant finding in several studies [4][5]7,13,[23][24][25][26]. In this study, 25 of 32 meningiomas (78%) were PR positive and more frequent in women (72%, n=18/25).…”

The Infratentorial Localization of Brain Metastases May Correlate with Specific Clinical Characteristics and Portend Worse Outcomes Based on Voxel-Wise Mapping

“…The notable advantage of voxel-wise approach is registering the MRI to a standard brain template (e.g., MNI152) for normalization, realizing the transformation of specific voxels to corresponding coordinates, which is immune to the MRI field strength [ 23 ]. Our previous work showed the preferred locations of meningiomas using the voxel-wise analysis [ 24 ]. Therefore, the voxel-wise approach could be useful to unfold the heterogenetic localization of BMs.…”