The Preemptive Analgesic Effect of Rofecoxib After Ambulatory Arthroscopic Knee Surgery

Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic ossification after hip replacement: A double-blind randomized trial of 100 patients with 1-year follow-up

“…Since rofecoxib had no gastrointestinal side effects, it did not have to be discontinued in any patient. In other investigations, rofecoxib in doses of up to 50 mg was found to be advantageous in postoperative control of pain due to COX-2 inhibition without any decrease in platelet aggregation (Reuben et al 2002, Ruvanendran et al 2003. Even so, there is recent evidence of cardiovascular complications after vioxx treatment (Gislason et al 2006).…”

Analgesic efficacy of preemptive pregabalin administration in arthroscopic shoulder surgery: a randomized controlled trial

“…15 Accordingly, the efficacy of several drugs as adjuvants has been studied, including NSAIDs, ketamine, local anesthetics, and opioids. [16][17][18][19] Recently, gabapentinoids have attracted attention in the surgical setting as an adjuvant to a multimodal postoperative pain management strategy. Gabapentinoids bind at the a2-d subunit of presynaptic voltage-gated calcium channels and exert analgesic effects by reducing the release of several excitatory neurotransmitters such as calcitonin gene-related peptide, glutamate, noradrenaline, and substance P. 20 Also, gabapentinoids administered before surgical trauma have been shown to interact with other analgesics additively or synergistically to decrease inflammatory hyperalgesia.…”

The Effect of Preemptive Intravenous Dexketoprofen Trometamol on Quality of Patient-Controlled Analgesia After Abdominal Hysterectomy

“…Although animal data suggested that the preemptive administration of analgesic drugs may reduce postoperative analgesic requirements, the clinical evidence supporting this claim has been questioned by several investigative groups [15]. Reuben et al reported that NSAIDs produced a "preemptive" effect when they were administered before versus after the surgical incision [16]. In a study by Tuncer et al [2], which looked at patients undergoing abdominal hysterectomy, dexketoprofen administered peri-operatively was found to reduce the need for opioids by providing a significant analgesic benefit in patients.…”