The Preeminent Value of the Apparent Diffusion Coefficient in Assessing High-Risk Factors and Prognosis for Stage I Endometrial Carcinoma Patients

Quan, Quan; Peng, Hui; Gong, Sainan; Liu, Jiali; Lu, Yi; Chen, Rongsheng; Mu, Xiaoling

doi:10.3389/fonc.2022.820904

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Diffusion-weighted imaging (DWI) reflects the restricted diffusion and movement of water molecules in tumour tissue and has been relatively maturely used in EC pathological features and prognostic evaluation indicators (18,19). Fat quantitation imaging (mDixon-Quant) based on chemical-shift encoding water-fat separation allows mapping of transverse relaxation rate (R2*) and fat fraction (FF), which reflect information on the paramagnetic material and fat content in tissues (20,21).…”

Section: Introductionmentioning

confidence: 99%

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

Shifeng,

Yue,

Wen

et al. 2023

Acta Radiol

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Background Endometrial carcinoma (EC) is the sixth most common cancer in women. P53 gene expression in patients with endometrial cancer can predict the efficacy and prognosis of patients with neoadjuvant therapy. Purpose To explore the value of multimodal magnetic resonance imaging (MRI) in differentiating p53 abnormal (p53abn) from p53 wild-type (p53wt) EC. Material and Methods Data from 47 EC patients, including 14 p53abn cases and 33 p53wt cases, were retrospectively analyzed. The preoperative MRI sequences included amide proton transfer weighted (APTw) imaging, T2 mapping, mDIXON-Quant imaging and diffusion-weighted imaging (DWI). After post-processing, APT, T2, transverse relaxation rate (R2*), fat fraction (FF) and apparent diffusion coefficient (ADC) maps were obtained. The APT, T2, R2*, FF and ADC values for lesions of the two groups of cases were measured by two observers who were blind to the pathological data. Results The APT value and R2* value in the p53abn group were higher than those in the p53wt group, while the ADC value was lower (all P < 0.05). There was no statistically significant difference in T2 value and FF value between the two groups (all P > 0.05). The area under curve of APT, R2*, ADC and combined APT + R2*+ADC values for identification of p53abn and p53wt EC were 0.739, 0.689, 0.718 and 0.820, respectively (all P > 0.05). Conclusion APTw, mDIXON-Quant and DWI techniques can be usedfor quantitative identification of p53abn and p53wt EC. The multimodal MRI provides a new way for preoperative quantitative evaluation of EC molecular typing, which has certain clinical application value.

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Section: Introductionmentioning

confidence: 99%

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

Shifeng,

Yue,

Wen

et al. 2023

Acta Radiol

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Apparent Diffusion Coefficient on Diffusion-Weighted Magnetic Resonance Imaging to Predict the Prognosis of Patients with Endometrial Cancer: A Meta-Analysis

Zhai,

Wang,

Wang

et al. 2024

Reprod. Sci.

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Diagnostic Accuracy of Apparent Diffusion Coefficient in Differentiating Malignant from Benign Endometrial Lesions, Taking Histopathology as Gold Standard

Seyal,

Siddique,

Shams

et al. 2024

PJHS

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Endometrial cancer is the cancer of the inner lining of the uterus. Histopathology is considered a gold standard invasive diagnostic test for it. However, Magnetic Resonance Imaging (MRI) based Diffusion-Weighted Imaging (DWI) and apparent diffusion coefficients (ADC) values are non-invasive tests that can differentiate malignant endometrial lesions from benign conditions. Objective: To assess the diagnostic accuracy of MR DWI in differentiating benign from malignant endometrial lesions taking histopathology as a gold standard. Methods: This cross sectional study was carried out at Radiology Ward Lahore General Hospital Lahore for six months. A total of 132 women between 25-55 years of age, with abnormal vaginal bleeding were included. In all patients, diffusion-weighted MRI (DE-MRI) of the pelvis was done followed by histopathology. DW-MRI and histopathology findings were compared. Data were analyzed on SPSS 20.0. The Sensitivity, Specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and diagnostic accuracy were measured using 2×2 contingency table. P-value of <0.001 was taken as significant. Results: DW-MRI diagnosed endometrial cancer in 75 patients while 57 patients didn’t show any malignant lesion. Histopathology confirmed endometrial cancer in 79 cases and benign lesion in 53. Out of 75 positive DW-MRI patients, 72 were True Positive (TP). Out of 57 negative DW-MRI patients, 07 were True negative (TN). Sensitivity, Specificity, PPV, NPV and diagnostic accuracy were 91.14%, 94.34%, 96.0%, 97.72% and 92.42% respectively. Conclusions: DWI based apparent diffusion coefficients (ADC) can more accurately diagnose endometrial cancers than benign lesions. Hence it can be useful adjunct for diagnosis of endometrial lesions.

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The Preeminent Value of the Apparent Diffusion Coefficient in Assessing High-Risk Factors and Prognosis for Stage I Endometrial Carcinoma Patients

Cited by 3 publications

References 41 publications

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma

Apparent Diffusion Coefficient on Diffusion-Weighted Magnetic Resonance Imaging to Predict the Prognosis of Patients with Endometrial Cancer: A Meta-Analysis

Diagnostic Accuracy of Apparent Diffusion Coefficient in Differentiating Malignant from Benign Endometrial Lesions, Taking Histopathology as Gold Standard

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