The predictors of cholelithiasis in female patients with metabolic syndrome

Cojocaru, Doina-Clementina; Mitu, Florin; Dascălu, Cristina Gena; Manole, Alina; Dima-Cozma, Corina

doi:10.2478/s11536-013-0255-5

“…In terms of direct bilirubin, also normal mean Although there is no parallel relationship with blood lipids level, increased lipid components excretion through bile directly promote the formation of cholesterol stones. Total cholesterol, direct bilirubin and especially lean body weight might provide simple stratification tools for obese women, outlining a high risk profile for developing gallstones [43].…”

Section: Discussionmentioning

confidence: 99%

The association between gallstone disease and metabolic syndrome related abnormalities: a systematic review and meta-analysis

Jiang¹,

Ni

²

,

Huang³

et al. 2020

Int J Diabetes Dev Ctries

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Background Bile excretion is one of an important metabolite excretion pathway of human body. In recent years, it has been reported that metabolic diseases are associated with the occurrence of GSD (Gallstone Disease). The main purpose of this systematic review is to examine the relationship between metabolic syndrome and cholelithiasis, including components of the metabolic syndrome such as abnormal blood glucose regulation, hyperlipidemia, and obesity. Methods Pubmed, Cochrane library and embase were searched for all English language articles for the following relevant keywords: Metabolic Syndrome, Reaven Syndrome X, Biliary Calculi, Cholelithiasis Gallstones. Case-control study, cross-sectional study and cohort study were included .Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The pooled mean differences of the outcome measures were compared between patients with and without MetS. Results After screening, a total of 5 cross-sectional studies and 1 cohort studies were included in the metaanalysis. The 6 studies evaluated a total of 49101 people of whom 9055 had MS and 2308 had GSD. There is a significant correlation between MS and GSD (z=6.65, p = 0.000), and it's more significant in female. All studies displayed increasing odds of GSD with increasing number of MetS traits, where patients with three or more MetS traits tended to have a higher prevalence of nephrolithiasis. Conclusions Our review shows a definite association of MetS with GSD, and the more the components of MetS, the higher the prevalence of GSD. Although not as obvious as women, men also support this conclusion. Background Gallstones disease (GSD) are the most common digestive disease needing admission to hospital in the West. With a prevalence of 10-15% in adults in Europe and the USA, 5-20% in Asian populations gallstone disease is one of the most common and most expensive to treat of digestive disorders that need admission to hospital[1-4]. It constituting a major health burden that has increased more than 20% over the last 3 decades in the US[5]. Gallstones are a disease that is more common in female than in male[6]. Risk factors include gender, obesity, and chronic liver diseases such as fatty liver, cirrhosis, and gastrectomy. Patients such as diabetes are also susceptible to gallstone disease[7]. Metabolic syndrome (MetS) is a state in which multiple metabolic risk factors for cardiovascular disease build up within an individual [8]. The main components of MetS are obesity, especially visceral obesity, diabetes, or impaired glucose regulation, hypertension and lipid disorders which are characterized by hypertriglyceridemia (TG) and low-density lipoprotein cholesterol (HDL-C). In addition, MS also includes tissue insulin resistance, hyperuricemia, and microalbuminuria that reflects vascular endothelial cell dysfunction.[9, 10]. The prevalence of metabolic syndrome has increased dramatically worldwide[8, 11, 12]. Studies about the association between gallstone disease...

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“…Although there is no parallel relationship with blood lipids level, increased lipid components excretion through bile directly promote the formation of cholesterol stones. Total cholesterol, direct bilirubin and especially lean body weight might provide simple strati cation tools for obese women, outlining a high risk pro le for developing gallstones [43].…”

Section: Discussionmentioning

confidence: 99%

The Association Between Gallstone Disease and Metabolic Syndrome Related Abnormalities: A Systematic Review and Meta-Analysis

Jiang¹,

Ni²,

Huang³

et al. 2020

Preprint

0

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BackgroundBile excretion is one of an important metabolite excretion pathway of human body. In recent years, it has been reported that metabolic diseases are associated with the occurrence of GSD (Gallstone Disease). The main purpose of this systematic review is to examine the relationship between metabolic syndrome and cholelithiasis, including components of the metabolic syndrome such as abnormal blood glucose regulation, hyperlipidemia, and obesity.MethodsPubmed, Cochrane library and embase were searched for all English language articles for the following relevant keywords: Metabolic Syndrome, Reaven Syndrome X, Biliary Calculi, Cholelithiasis Gallstones. Case-control study, cross-sectional study and cohort study were included .Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The pooled mean differences of the outcome measures were compared between patients with and without MetS.ResultsAfter screening, a total of 5 cross-sectional studies and 1 cohort studies were included in the meta-analysis. The 6 studies evaluated a total of 49101 people，of whom 9055 had MS and 2308 had GSD. There is a significant correlation between MS and GSD (z=6.65, p = 0.000), and it’s more significant in female. All studies displayed increasing odds of GSD with increasing number of MetS traits, where patients with three or more MetS traits tended to have a higher prevalence of nephrolithiasis.ConclusionsOur review shows a definite association of MetS with GSD, and the more the components of MetS, the higher the prevalence of GSD. Although not as obvious as women, men also support this conclusion.

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“…Commonly, this disorder occurs asymptomatically, and only 20% of people with cholelithiasis experience pain and complications. The most common risk factor of cholelithiasis is gender, with females being one of the unmodifiable risk factors and is also related to metabolic syndrome events [4]. Pimpale et al [5] stated that cholelithiasis is commonly found in females in the 4 th to 5 th decade of life, with abdominal pain being the most typical symptom.…”

Section: Introductionmentioning

confidence: 99%

Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice

2020

ARGH

0

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Cholelithiasis is one of the most prevalent diseases in gastroenterology. There are many factors in cholelithiasis, such as genetic, lack of physical activity, obesity, dietary, age, and other comorbidities. Commonly, cholelithiasis occurs asymptomatically; however, Murphy's sign is one of the most frequent pathognomonic findings in abdominal examination. Ultrasonography is known as the gold standard imaging examination in diagnosing cholelithiasis. The management of cholelithiasis can be divided into two categories, such as medical treatment and surgical treatment, which depends on the patient's condition.

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The predictors of cholelithiasis in female patients with metabolic syndrome

Cited by 6 publications

References 18 publications

The association between gallstone disease and metabolic syndrome related abnormalities: a systematic review and meta-analysis

The association between gallstone disease and metabolic syndrome related abnormalities: a systematic review and meta-analysis

The Association Between Gallstone Disease and Metabolic Syndrome Related Abnormalities: A Systematic Review and Meta-Analysis

Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice

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