The Predictivity of Serum Biochemical Markers in  Acute Biliary Pancreatitis

Güngör, Bülent; Çağlayan, Kasım; Polat, Cafer; Şeren, Deniz; Erzurumlu, Kenan; Malazgirt, Zafer

doi:10.5402/2011/279607

Cited by 30 publications

(37 citation statements)

References 22 publications

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“…30 In addition to PEP, overall complications of ERCP were 1.52times higher in women. 29 In contrast, there was no significant association between age or sex and PEP in our study, even slightly higher risk of PEP, but not significant, was observed. Interestingly, lack of association between age and sex and the risk of PEP also has been observed by Cheng et al 31 In the searching for patient-related risk factors, previous evidences has reported that post-ERCP elevation of inflammatory and biochemical markers could be a potential predictors of PEP.…”

Section: Discussioncontrasting

confidence: 87%

“…In relation to patient-related risk factors, previous studies have discussed that being female and younger ages were significant risk factors for PEP. 29 The impact of age seems to be related to protective effect of progressive decline in pancreatic exocrine function by aging. 30 In addition to PEP, overall complications of ERCP were 1.52times higher in women.…”

Section: Discussionmentioning

confidence: 99%

“…34 However, later reports have not mentioned these variables as significant risk factors of PEP. 29 Although they alternatively added other risk factors, such as cannulation time and periampullary diverticulum, as significantly related to pancreatitis. 29 Our observation suggested that balloon dilation of S.O.…”

Section: Discussionmentioning

confidence: 99%

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The comparison between combination of pancreatic stent and nsaid with nsaid alone in preventing post ERCP pancreatitis

Heidarnezhad¹,

Mohammad²

2018

GHOA

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ERCP as a diagnostic and therapeutic tool for biliary tract and pancreatic diseases is associated with many complications such as Pancreatitis, bleeding, perforation, and cardiovascular consequences. A recent survey showed that the use of non-steroid antiinflammatory drugs before ERCP could reduce risk of pancreatitis after ERCP. In order to assess this hypothesis in the patients admitted to Taleghani hospital, Tehran, Iran, with CBD stone, we designed the current study. After randomized selection and division of the patients to different groups; the patient's candidate for pancreatic duct stent (PD stent) and Indomethacin-supplement procedure and the patients under Indomethacin-supplement process alone. After evaluating different variabilities as sex, age, Post ERCP Pancreatitis (PEP) with use of PD stent, PEP with use of indomethacin-supplement and PD stent, medications, type of disease, laboratory test such as CBC, AST, ALT and bilirubin test, ERCP was conducted by one expert specialist. Blinding of the staff and analysis department was conducted as well. Data analysis showed that <10 minutes of cannulation could decrease the incidence of PEP in our study (P-value<0.05), while other variables did not manifested any correlation with the incidence of PEP. In conclusion, we showed the evidence that different interventional elements or patient associated risk factors had no significantly effect on PEP incidence. However, deep cannulation time as the important factor of procedure could alter the rate of PEP.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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The comparison between combination of pancreatic stent and nsaid with nsaid alone in preventing post ERCP pancreatitis

Heidarnezhad¹,

Mohammad²

2018

GHOA

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“…Here, in idiopathic AP, we defined the elevation of serum alkaline phosphatase (ALP) and increased alanine aminotransferase (ALT) (≥3 times the upper limit of normal) as findings suggestive of microlithiasis. [16][17][18][19][20] …”

Section: Definitionmentioning

confidence: 99%

“…27,28 Several studies have shown that elevated ALP is a common marker for diagnosing gallstone-induced pancreatitis. 16,18 Several recent reports proposed that the ALT level might be a marker for early recognition of a gallstone etiology in patients with AP. 17,19,20,29 In particular, increased ALT, ≥3-fold the normal level, highly suggests microlithiasis.…”

Section: 2412mentioning

confidence: 99%

The Etiologic Evaluation of Acute Pancreatitis in a General Hospital of Seoul-Gyeonggi Province in Korea

Youn

Chung

Lee

et al. 2017

Korean J Gastroenterol

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Background/Aims: In recent years, the incidence of acute pancreatitis (AP) has been increasing. A better understanding of the etiology is directly linked to more favorable outcomes. Unfortunately, there have been reports suggesting the variation of etiologies of AP across countries. The objective of this study was to determine the etiology of AP in a general hospital of Seoul-Gyeonggi province in Korea during the past decade. Methods: We retrospectively reviewed the medical records of consecutive patients with AP who were admitted to St. Paul's Hospital (Seoul, Korea) with an affiliation to the Catholic University of Korea between January 2003 and January 2013. Results: A total of 1,110 patients were enrolled, totaling 1,833 attacks, and the most frequent cause of AP was alcohol consumption. The recurrence rate of AP was 24.5% (272/1,110), and habitual recurrence rate (more than three times) was 12.6% (140/1,110). The rate of severe AP was 4.9% (90/1,833 attacks). The mortality rate of AP was 2.6% (29/1,110 patients). The frequency of an idiopathic cause of AP was 13.3%. The recurrence rate and mortality rate of idiopathic AP were 16.2% and 5.4%, respectively. In 41.7% (10/24) of cases of idiopathic AP, microlithiasis was suspected. Conclusions: Between 2003 and 2013 in Korea, alcohol was the most frequent cause of AP in the general hospital of Seoul-Gyeonggi province of Korea. It appears that alcohol abstinence program may be necessary. Further nationwide studies would be needed to evaluate the etiologies of AP. (Korean J Gastroenterol 2017;70:190-197)

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Protective effects of tropisetron on cerulein-induced acute pancreatitis in mice

Rahimian

Zirak

Seyedabadi

et al. 2017

Biomedicine & Pharmacotherapy

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Acute pancreatitis (AP) causes morbidity and mortality. The aim of the present study was to investigate the protective effect of tropisetron against AP induced by cerulein. Cerulein (50μg/kg, 5 doses) was used to induce AP in mice. Six hours after final cerulein injection, animals were decapitated. Hepatic/pancreatic enzymes in the serum, pancreatic content of malondialdehyde (MDA), pro-inflammatory cytokines and myeloperoxidase (MPO) activity were measured. Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice. Tropisetron didn't affect the pancreatic levels of MDA. Our results suggest that tropisetron could attenuate cerulein-induced AP by combating inflammatory signaling. Further clinical studies are needed to confirm its efficacy in patients with AP.

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The Predictivity of Serum Biochemical Markers in Acute Biliary Pancreatitis

Cited by 30 publications

References 22 publications

The comparison between combination of pancreatic stent and nsaid with nsaid alone in preventing post ERCP pancreatitis

The comparison between combination of pancreatic stent and nsaid with nsaid alone in preventing post ERCP pancreatitis

The Etiologic Evaluation of Acute Pancreatitis in a General Hospital of Seoul-Gyeonggi Province in Korea

Protective effects of tropisetron on cerulein-induced acute pancreatitis in mice

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