The Predictive Value of the EWGSOP Definition of Sarcopenia: Results From the InCHIANTI Study

Bianchi, Luca; Ferrucci, Luigi; Cherubini, Antonio; Maggio, Marcello; Bandinelli, Stefania; Savino, E.; Brombo, Gloria; Zuliani, Giovanni; Guralnik, Jack M.; Landi, Francesco; Volpato, Stefano

doi:10.1093/gerona/glv129

Cited by 168 publications

(143 citation statements)

References 38 publications

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“…Low skeletal muscle mass, estimated by the crosssectional area of muscle on abdominal CT scan, a previously validated measure of sarcopenia in older adults (77), is independently associated with in-hospital mortality in older trauma ICU patients and adults receiving mechanical ventilation (78,79). These findings are consistent with prior studies in community-dwelling older adults showing low muscle mass increases the risk for subsequent disability and mortality (80)(81)(82).…”

Section: Biological Correlates Of Frailty In Critically Ill Adultssupporting

confidence: 85%

Frailty in Pulmonary and Critical Care Medicine

Singer

Lederer²,

Baldwin

2016

Annals ATS

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Conceptualized first in the field of geriatrics, frailty is a syndrome characterized by a generalized vulnerability to stressors resulting from an accumulation of physiologic deficits across multiple interrelated systems. This accumulation of deficits results in poorer functional status and disability. Frailty is a "state of risk" for subsequent disproportionate declines in health status following new exposure to a physiologic stressor. Two predominant models have emerged to operationalize the measurement of frailty. The phenotype model defines frailty as a distinct clinical syndrome that includes conceptual domains such as strength, activity, wasting, and mobility. The cumulative deficit model defines frailty by enumerating the number of age-related things wrong with a person. The biological pathways driving frailty include chronic systemic inflammation, sarcopenia, and neuroendocrine dysregulation, among others. In adults with chronic lung disease, frailty is independently associated with more frequent exacerbations of lung disease, all-cause hospitalization, declines in functional status, and all-cause mortality. In addition, frail adults who become critically ill are more likely develop chronic critical illness or severe disability and have higher in-hospital and long-term mortality rates. The evaluation of frailty appears to provide important prognostic information above and beyond routinely collected measures in adults with chronic lung disease and the critically ill. The study of frailty in these populations, however, requires multipronged efforts aimed at refining clinical assessments, understanding the mechanisms, and developing therapeutic interventions.Keywords: frailty; body composition; disability; health-related quality of life; mortality Correspondence and requests for reprints should be addressed to Jonathan P. Singer, M.D., M.S.,

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Section: Biological Correlates Of Frailty In Critically Ill Adultssupporting

confidence: 85%

Frailty in Pulmonary and Critical Care Medicine

Singer

Lederer²,

Baldwin

2016

Annals ATS

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“…Sarcopenia is therefore considered a geriatric syndrome defined as a progressive impairment of muscle function due to the loss of skeletal muscle mass that occurs with advancing age (2). In older people, sarcopenia is a powerful risk factor for mobility impairment, disability, loss of independence, hospitalization, and death (3). The clinical implications of this geriatric syndrome have been reported consistently across different settings, including community-dwelling samples, nursing homes, and acute care departments (4).…”

mentioning

confidence: 99%

Prevalence and Clinical Correlates of Sarcopenia, Identified According to the EWGSOP Definition and Diagnostic Algorithm, in Hospitalized Older People: The GLISTEN Study

Bianchi

Abete

Bellelli

et al. 2017

The Journals of Gerontology: Series A

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108

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Background: Prevalence of sarcopenia is substantial in most geriatrics settings, but estimates vary greatly across studies because of difference in population characteristics, diagnostic criteria, and methods used to assess muscle mass, muscle strength, and physical performance. We investigated the feasibility of the European Working Group on Sarcopenia in Older People (EWGSOP) algorithm assessment in hospitalized older adults and analyzed prevalence and clinical correlates of sarcopenia. Methods: Cross-sectional analysis of 655 participants enrolled in a multicenter observational study of older adults admitted to 12 acute hospital wards in Italy. Sarcopenia was assessed as low skeletal mass index (kg/m 2 ) plus either low handgrip strength or low walking speed (EWGSOP criteria). Skeletal muscle mass was estimated using bioimpedance analysis. Results: Of the 655 patients (age 81.0 ± 6.8 years; women 51.9%) enrolled in the study, 275 (40.2%) were not able to perform the 4-m walking test because of medical problems. The overall prevalence of sarcopenia on hospital admission was 34.7% (95% confidence interval 28-37) and it steeply increased with aging (p < .001). In multivariable analysis, patients with sarcopenia on hospital admission were older and were more likely to be male and to have congestive heart failure, cerebrovascular disease, and severe basic activities of daily living disability. The prevalence of sarcopenia was inversely correlated with body mass index.

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“…Later research however, demonstrated that, besides skeletal muscle mass, also muscle strength and/or physical performance were important in the clinical specification of sarcopenia. Since then, a revolution in the concept of the definition of sarcopenia had been set [3][4][5] . Several international research groups, including the European Working Group on Sarcopenia in Older People (EWGSOP), use these three determinants to present their clinical definition for the diagnosis of sarcopenia 6,7 .…”

Section: Introductionmentioning

confidence: 99%

“…Sarcopenia is known to be associated with an increased risk for several adverse outcomes such as frailty, hospitalization, disability and mortality 4,13,14 . Especially the determinants muscle mass, muscle strength and physical performance have been found to play a major part in the increased risk of these adverse outcomes 4,5 . Also, sarcopenic patients with a diminished nutritional status have been shown to be at greater risk of dying in the shortterm 15 .…”

Section: Introductionmentioning

confidence: 99%

The mortality determinants of sarcopenia and comorbidities in hospitalized geriatric patients

Lamers

Degerickx

Vandewoude

et al. 2017

JFSF

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The Predictive Value of the EWGSOP Definition of Sarcopenia: Results From the InCHIANTI Study

Abstract: The EWGSOP's phenotype is a good predictor of incident disability, hospitalization and death. Assessment of only muscle weakness, in addition to low muscle mass, provided similar predictive value as compared to the original algorithm.

Cited by 168 publications

References 38 publications

Frailty in Pulmonary and Critical Care Medicine

Frailty in Pulmonary and Critical Care Medicine

Prevalence and Clinical Correlates of Sarcopenia, Identified According to the EWGSOP Definition and Diagnostic Algorithm, in Hospitalized Older People: The GLISTEN Study

The mortality determinants of sarcopenia and comorbidities in hospitalized geriatric patients

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