The Predictive value of serum NGAL for the diagnosis of Delayed Graft Function in kidney transplantation

Pourmand, Gholamreza; Emamjomeh, Behrouz; Gooran, Shahram; Namdari, Farshad; Mehrsay, A; Dehghani, Sanaz; Mashhadi, Rahil; Aghaii, Maryam; Bagherpour, Farzaneh; Heidari, Fariba; Ashtari, Sara; Khatami, Fatemeh; Aghamir, Seyed Mohammad Kazem

doi:10.21203/rs.2.24586/v1

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…These days, the genes that govern the acceptance or rejection of a transplant are at the center of attention. Several studies have shown that proteins, DNA, and RNA could be promising candidate biomarkers for monitoring renal transplantation rejection [ 3 , 4 , 5 , 6 , 7 ]. The putative genes that play a role in the survival of transplanted cells, tissues, or organs belong to a family called the major histocompatibility complex (MHC) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Whole Exome Sequencing to Find Candidate Variants for the Prediction of Kidney Transplantation Efficacy

Aghamir

Roudgari

Heidari

et al. 2023

Genes

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Introduction: Kidney transplantation is the optimal treatment strategy for some end-stage renal disease (ESRD); however, graft survival and the success of the transplantation depend on several elements, including the genetics of recipients. In this study, we evaluated exon loci variants based on a high-resolution Next Generation Sequencing (NGS) method. Methods: We evaluated whole-exome sequencing (WES) of transplanted kidney recipients in a prospective study. The study involved a total of 10 patients (5 without a history of rejection and 5 with). About five milliliters of blood were collected for DNA extraction, followed by whole-exome sequencing based on molecular inversion probes (MIPs). Results: Sequencing and variant filtering identified nine pathogenic variants in rejecting patients (low survival). Interestingly, in five patients with successful kidney transplantation, we found 86 SNPs in 63 genes 61 were variants of uncertain significance (VUS), 5 were likely pathogenic, and five were likely benign/benign. The only overlap between rejecting and non-rejecting patients was SNPs rs529922492 in rejecting and rs773542127 in non-rejecting patients’ MUC4 gene. Conclusions: Nine variants of rs779232502, rs3831942, rs564955632, rs529922492, rs762675930, rs569593251, rs192347509, rs548514380, and rs72648913 have roles in short graft survival.

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Section: Introductionmentioning

confidence: 99%

Whole Exome Sequencing to Find Candidate Variants for the Prediction of Kidney Transplantation Efficacy

Aghamir

Roudgari

Heidari

et al. 2023

Genes

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A narrative review on adverse drug reactions of COVID-19 treatments on the kidney

Jahanshahi,

Jazayeri,

Eraghi

et al. 2024

Open Medicine

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Studies showed that the respiratory is not the only system affected by coronavirus 2, while cardiovascular, digestive, and nervous systems, as well as essential organs such as the kidneys, can be affected by this virus. In this review, we have studied the epidemiology, clinical, and laboratory findings on COVID-19 infection renal involvement, mortality, physiopathology, remaining renal sequels after recovery, underlying renal disease, and renal injury due to its treatment. Also, protective measures for kidney injury are explained in three levels. Evidence of viral particles and genome in the urine and renal tubular cells and signs of damage such as microangiopathy, hypercoagulopathy, and fibrosis are found in COVID-19 patients. The result of this study showed, in hospitalized COVID-19 patients, that the rate of acute kidney injury (AKI) was up to 46%, with a mortality ranging from 11 to 96%. A considerable proportion of patients with AKI would remain on renal replacement therapy. Proteinuria and hematuria are observed in 87 and 75% patients, and increased Cr and glomerular filtration rate (GFR) <60 ml/min per 1.73 m2 are observed in 29.6 and 35.3% of the patients, respectively. Remedsivir is considered to have adverse effects on GFR. COVID-19 patients need special attention to prevent AKI. Those with underlying chronic kidney disease or AKI need proper and explicit evaluation and treatment to improve their prognosis and decrease mortality, which should not be limited to the hospitalization period.

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The Predictive value of serum NGAL for the diagnosis of Delayed Graft Function in kidney transplantation

Cited by 2 publications

References 19 publications

Whole Exome Sequencing to Find Candidate Variants for the Prediction of Kidney Transplantation Efficacy

Whole Exome Sequencing to Find Candidate Variants for the Prediction of Kidney Transplantation Efficacy

A narrative review on adverse drug reactions of COVID-19 treatments on the kidney

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