The Predictive Value of Serum Uric Acid on Acute Kidney Injury following Traumatic Brain Injury

Abstract

Backgrounds. Acute kidney injury (AKI) is a prevalent nonneurological complication in patients with traumatic brain injury (TBI). We designed this study to explore the association between serum uric acid (SUA) level and the occurrence of AKI following TBI. Methods. This is a retrospective single-center study. A total of 479 patients admitted with TBI were included in this study. We utilized SUA and other risk factors for AKI to construct a predictive model by performing multivariate logistic regression. 374 patients and 105 patients were, respectively, divided into a training set and validation set. The predictive value of the single SUA and constructed model was evaluated by drawing a receiver operating characteristic (ROC) curve. AKI was diagnosed according to the KIDGO criteria. Results. 79 (21.12%) patients were diagnosed with AKI in the training cohort. The patients in the AKI group are older than those in the non-AKI group (p=0.01). And the Glasgow Coma Scale (GCS) of the AKI group was lower than that of the non-AKI group (p<0.001). In a multivariate logistic regression analysis, we found that heart rate (p=0.041), shock (p=0.018), serum creatinine (p<0.001), and serum uric acid (SUA) (p<0.001) were significant risk factors for AKI. Bivariate correlation analyses showed that serum creatinine was moderately positively correlated with SUA (r=0.523, p<0.001). Finally, the area under the receiver operating characteristic curve (AUC) of SUA for predicting AKI in the training set and validation set was 0.850 (0.805-0.895) and 0.869 (0.801-0.938), respectively. Conclusions. SUA is an effective risk factor for AKI following TBI. Combining SUA with serum creatinine could more accurately identify TBI patients with high risk of developing AKI.

Development and Validation of a dynamic online nomogram predicting acute kidney injury in critically ill patients with cirrhosis

“…In the ICU, the GCS scoring system is commonly used to evaluate the severity of a patient's condition. Our results revealed that patients with a low GCS score were more likely to develop AKI, which is consistent with previous studies [30,31]. Infection, particularly sepsis, is the most important risk factor for renal function [32].…”

Interaction between Hyperuricemia and Admission Lactate Increases the Risk of Acute Kidney Injury in Patients with ST-Segment Elevation Myocardial Infarction

“…For instance, Cheungpasitporn et al [20] reported that increased SUA at admission is linked to an increased risk of AKI in hospital. Elsewhere, Wang et al [21] also noted that SUA is an effective risk factor for AKI after traumatic brain injury.…”

Systemic immune-inflammation index may predict the acute kidney injury and prognosis in patients with spontaneous cerebral hemorrhage undergoing craniotomy: a single-center retrospective study

“…The SII showed a better manifestation than the SUA owing its larger AUC and superior sensitivity and specificity. SUA is also a risk factor for AKI in other clinical settings [ 32 – 34 ], and it is an independent risk factor for the development of stage 3 AKI in patients with spontaneous intracerebral hemorrhage [ 35 ]. SUA levels could not predict AKI severity in our study.…”