The predictive value of serum progesterone and 17-OH progesterone levels onin vitro fertilization outcome

Levy, Michael J.; Smotrich, David B.; Widra, E.A.; Sagoskin, Arthur W; Murray, Denise L.; Hall, Jerry L.

doi:10.1007/bf02211792

Cited by 28 publications

(5 citation statements)

References 21 publications

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“…There have already been many papers published on this topic; however, some of them do not show a relationship between progesterone levels and pregnancy rates (Check, 1994;Bustillo et al, 1995;Levy et al, 1995;Miller et al, 1996;Venetis et al, 2007;Edelstein et al, 1990;Ubaldi et al, 1995;Silverberg et al, 1991). The latter work is a meta-analysis, which has some points of controversy like the lack of uniformity regarding the type of GnRH analogue used as well as the cutoff to define elevated serum progesterone.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Serum Progesterone Levels on the Results ofIn VitroFertilization Treatments: A Literature Review

Castillo

Bousamra

Fuente

et al. 2015

JBRA Assisted Reproduction

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The aim of this review is to analyze the relationship between preovulatory progesterone (P) rise and in vitro fertilization (IVF) pregnancy outcomes. It also investigates the sources and effects of rises in progesterone levels, including the underlying mechanisms and potential strategies in preventing its elevation during ovarian stimulation. Progesterone is produced in the early follicular phase in the adrenal gland, which shifts toward the ovaries prior to ovulation. Several factors contribute to the etiology of P level increase including the number of multiple follicles, the overdose of gonadotropins and poor ovarian response. Nowadays, the influence of the preovulatory P rise on IVF outcome remains controversial. Several authors have failed to demonstrate any negative impact, while others reported a detrimental effect associated with the rise of P. It seems that P rise (1.5 ng/ml or 4.77 nmol/l) may have deleterious effects on endometrial receptivity, namely, accelerating the endometrial maturation process that subsequently narrows the period for implantation and thus decreases pregnancy rates. Recent studies have proposed different cutoffs according to the ovarian response, which may be a little high in patients with high response in relation to those of normal response or low response. To prevent a P rise, it might be preferable to use milder stimulation protocols, earlier trigger of ovulation, cryopreservation of all embryos and transfer in the natural cycle.

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Section: Discussionmentioning

confidence: 99%

The Impact of Serum Progesterone Levels on the Results ofIn VitroFertilization Treatments: A Literature Review

Castillo

Bousamra

Fuente

et al. 2015

JBRA Assisted Reproduction

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“…Although serum progesterone concentration in the late follicular phase is considerably lower than that observed in connection with the mid-cycle surge of gonadotrophins or as induced by human chorionic gonadotrophin (HCG) for ovulation induction, even subtle increases in relatively low progesterone concentrations have been suspected to negatively affect ongoing pregnancy rates in connection with ovarian stimulation, possibly through an advancement of endometrial maturation (Fanchin et al, 1997a;Smitz et al, 2007). A number of studies have reported a negative association between progesterone concentration and clinical pregnancy rate (Azem et al, 2008;Bosch et al, 2003Bosch et al, , 2010Check et al, 1993;Fanchin et al, 1993Fanchin et al, , 1997bHarada et al, 1996;Shulman et al, 1996), while many others found no association (Abuzeid and Sasy, 1996;Bustillo et al, 1995;Check, 1994;Doldi et al, 1999;Edelstein et al, 1990;Givens et al, 1994;Hofmann et al, 1993;Levy et al, 1995;Martinez et al, 2004;Miller et al, 1996;Moffitt et al, 1997;Niu et al, 2008;Silverberg et al, 1991;Ubaldi et al, 1995;Urman et al, 1999;Venetis et al, 2007). Collectively, in 2007 a meta-analysis concluded that there was no statistical association between the late-follicular-phase progesterone concentrations and the ongoing pregnancy rates (Venetis et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate

Andersen

Bungum

Andersen

et al. 2011

Reproductive BioMedicine Online

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“…Pre HCG progesterone rise was defined by many studies that serum P more than 0.8-2 ng/ml [3,6,13,14] , however in most of these studies, the threshold for P was demonstrated arbitrary.…”

Section: Discussionmentioning

confidence: 99%

“…The impact of subtle P rise on the day of HCG administration on IVF/ICSI outcome is controversial; some studies showed that it has no association with pregnancy rates (PRs) [4,[6][7][8][9][10] , whereas others showed that it has negative impact [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Serum progesterone concentrations before and after human chorionic gonadotropin triggering and invitro fertilization : Intracytoplasmic sperm injection cycle outcome in long gonadotrophin releasing hormone agonist protocol

Shaban

Bassiouny

Alahwany

2018

Evidence Based Women's Health Journal

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Objective: To assess the impact of serum progesterone concentrations before and after HCG triggering on IVF/ICSIcycle outcomes in long GnRHa protocol. Patients and Methods: This is a single-center prospective observational cohort study, in which 102 IVF/ICSI patients with normal cycle day 2 basal hormones were recruited and underwent ovarian stimulation using the long GnRHa protocol. Serum progesterone on the day of HCG trigger; one day after, progesterone/estradiol was assessed and correlated with pregnancy rates, the total dose of used gonadotropins, serum estradiol level on day of trigger, the number of collected oocytes, the number of metaphase II oocytes and the quality of transferred embryos. Results: 96 women were included in the analysis. In our study, the receiver-operating characteristic (ROC) analysis was used to gain more diagnostic accuracy. Our data according to ROC analysis showed that the P levels on the day of hCG trigger, and its levels one day after and P/E2 on the day of hCG trigger had no role in prediction of clinical pregnancy rates. There was significant correlation between the serum progesterone levels before and after HCG triggering with the total dose of gonadotropins used. They also correlated strongly with serum estradiol level on day of trigger, the number of collected oocytes and the number of metaphase II oocytes. Conclusion: Peri-ovulatory serum progesterone concentrations cannot predict pregnancy rates in IVF/ICSI cycles using long GnRHa protocol.

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The predictive value of serum progesterone and 17-OH progesterone levels onin vitro fertilization outcome

Abstract: Excellent clinical pregnancy rates were noted in cycles with a progesterone level of 0.7-0.8 ng/ml, as well as good results in cycles above 0.8 ng/ml. There is therefore no reason to administer human chorionic gonadotropin at a smaller follicle size to prevent a rise in serum progesterone.

Cited by 28 publications

References 21 publications

The Impact of Serum Progesterone Levels on the Results ofIn VitroFertilization Treatments: A Literature Review

The Impact of Serum Progesterone Levels on the Results ofIn VitroFertilization Treatments: A Literature Review

Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate

Serum progesterone concentrations before and after human chorionic gonadotropin triggering and invitro fertilization : Intracytoplasmic sperm injection cycle outcome in long gonadotrophin releasing hormone agonist protocol

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