The predictive value of metabolic syndrome for cardiovascular and all‐cause mortality: Tehran Lipid and Glucose Study

Amouzegar, Atieh; Mehran, Ladan; Hasheminia, Mitra; Rahimabad, Parnian Kheirkhah; Azizi, Fereidoun

doi:10.1002/dmrr.2819

Cited by 13 publications

(11 citation statements)

References 45 publications

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“…Pérez de José et al [37] analyzed the effects of MetS on cardiovascular events in 100 HD patients and found no difference in mortality between patients with or without MetS; however, they reported a higher hospitalization rate due to all causes in patients with MetS. Earlier investigations [38,39,40] pointed out that MetS increases the risk of mortality from CV and other diseases in the general population, but it is not yet fully clarified to what degree the existence of metabolic syndrome influences the mortality of HD patients. Our study demonstrated that HD patients have an increased risk of all-cause and CV mortality associated with MetS.…”

Section: Discussionmentioning

confidence: 99%

Associations of Cardiovascular and All-Cause Mortality with Metabolic Syndrome in Hemodialysis Patients: A Prospective Single-Center Study

et al. 2019

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Background and objectives: Metabolic syndrome (MetS) is a cluster of risk factors, such as abdominal obesity, insulin resistance, dyslipidemia and hypertension, that together increase the risk of cardiovascular disease. Chronic hemodialysis (HD) patients have multiple comorbidities and many metabolic disorders, causing the frequent occurrence of metabolic syndrome. The goal of this study was to assess the prevalence of MetS in HD patients, and its association with all-cause and cardiovascular (CV) mortality. Patients and methods: A total of 138 HD patients were included in this prospective study. We analyzed demographic, anthropometric and biochemical data. Outcome measures were all-cause and CV mortality during the three-year follow-up. Results: MetS was diagnosed in 57.24% of enrolled patients. During the 36 months of follow-up, 33 patients died. MetS patients showed a significantly higher mortality rate than non-MetS (30.4% versus 16.36%, p < 0.001). The association of different MetS components with cardiovascular mortality reached significance when a minimum of three components were present (1.81 (95% confidence interval CI = 1.21–2.33)), with a grouped increase in effect size for subjects with four or five MetS components. Subjects with MetS exhibited nearly twice as high risk for all-cause (hazard ratio HR = 1.99 (95%CI) = 1.42–2.97) and 2.5 times for CV (HR = 2.51 (95%CI) = 1.25–3.83) mortality compared with those without MetS, after adjustment for age, gender, and cardiovascular disease. Conclusions: The study demonstrates that MetS is widespread in HD patients. In future, the focus must be on an active screening approach, and treatment of cardiometabolic risk factors, aiming to reduce mortality.

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Section: Discussionmentioning

confidence: 99%

Associations of Cardiovascular and All-Cause Mortality with Metabolic Syndrome in Hemodialysis Patients: A Prospective Single-Center Study

et al. 2019

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“…Dyslipidemia, insulin resistance, elevated blood pressure, and abdominal obesity are metabolic alterations characterizing the MetS that in turn is associated with an increased risk for cardiovascular disease, mortality, and type 2 DM. It has been reported that PH patients with MetS had a higher pulmonary vascular resistance and higher mPAP values than PH patients without MetS .…”

Section: Pulmonary Hypertensionmentioning

confidence: 99%

Diabetic lung, an underrated complication from restrictive functional pattern to pulmonary hypertension

Fuso

Pitocco

Antonelli-Incalzi

2019

Diabetes Metabolism Res

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In patients with type 1 and type 2 diabetes mellitus (DM), respiratory function abnormalities have been reported with regard to lung volumes, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Indeed, the decrease in lung volumes and the impairment of diffusing capacity might have important clinical implications. Furthermore, there is an increasing evidence of a link between DM and pulmonary hypertension (PH) related to an involvement of the pulmonary vascular structures. These findings support the view of the lung as target organ in DM. In this paper, we briefly describe the main derangements of the respiratory system in DM and the inherent mechanisms.

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“…Metabolic syndrome (MetS) refers to a cluster of interrelated metabolic abnormalities such as increased blood pressure, hyperglycemia, central adiposity, insulin resistance, and dyslipidemia ( 16 , 17 ). It is well-recognized that MetS is a major risk factor for diabetes, cardiovascular diseases, and premature mortality ( 18 – 21 ), and previous studies also suggest a strong association between MetS and hyperuricemia and elevated SUA ( 22 , 23 ). Along with MetS, obesity is another well-known determinant of many diseases, cardiovascular diseases (CVD), and mortality ( 24 – 28 ), and its causal relationship with an increased risk of hyperuricemia has also been advocated by previous studies ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Differences in the Association of Metabolically Healthy Obesity With Hyperuricemia and a Network Perspective in Analyzing Factors Related to Hyperuricemia

et al. 2020

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Background Although obesity is a well-known risk factor for hyperuricemia, it remains unclear whether obese subjects with metabolically healthy status have a decreased the risk of hyperuricemia and whether sex modifies the association of metabolically healthy obesity (MHO) with hyperuricemia risk. We aimed to investigate the sex-specific association between MHO and other obesity phenotypes and hyperuricemia, and to use Bayesian networks to determine and visualize the interactions among hyperuricemia and its related factors. Methods This study was conducted using data from the China Health and Nutrition Survey 2009. Hyperuricemia was defined as serum uric acid ≥ 420 μmol/L in men and ≥ 360 μmol/L in women according to the guidelines. Body mass index (BMI) was used to define normal weight, overweight, and obese status in subjects, and metabolic health state was defined by the Adult Treatment Panel (ATP)-III and Visceral Adiposity Index (VAI) criteria, respectively. Subjects were categorized into six phenotypes according to their metabolic health and BMI level status. Results Of the 7,364 Chinese adult individuals included, the prevalence of hyperuricemia among MHO women was only 8.5% (95% CI 4.8 to 14.3%), but increased to 30.7% among MUO women, whereas the highest prevalence among men was found in the MUOW phenotype (39.4%, 95% CI 35.4 to 43.6%), compared to 15.4% for male subjects with MHO. After adjusting for confounders, the MHO phenotype was significantly associated with an increased risk of hyperuricemia compared with their MHNW counterparts in women (OR: 1.95, 95% CI: 1.02–3.74) whereas a significant association was not found in men (OR: 1.46, 95% CI: 0.8–2.68). A complex network structure was established by BNs and then used to find connections between hyperuricemia and its related factors, as well as their interrelationships. By using BN reasoning, the probability of having hyperuricemia was 0.076 among MHO men, while it reached 0.124 in MHO women. Conclusions In conclusion, our results demonstrated that the MHO phenotype was significantly associated with the risk of hyperuricemia only in women, not in men. This sex-specific differences in the association may suggest a favorable condition of MHO for Chinese men with respect to hyperuricemia risk, meanwhile more attention should be paid to the increased risk of hyperuricemia among MHO women.

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The predictive value of metabolic syndrome for cardiovascular and all‐cause mortality: Tehran Lipid and Glucose Study

Abstract: Diagnosis of MetS seems no more informative than its individual components in predicting mortality. Copyright © 2016 John Wiley & Sons, Ltd.

Cited by 13 publications

References 45 publications

Associations of Cardiovascular and All-Cause Mortality with Metabolic Syndrome in Hemodialysis Patients: A Prospective Single-Center Study

Associations of Cardiovascular and All-Cause Mortality with Metabolic Syndrome in Hemodialysis Patients: A Prospective Single-Center Study

Diabetic lung, an underrated complication from restrictive functional pattern to pulmonary hypertension

Sex-Specific Differences in the Association of Metabolically Healthy Obesity With Hyperuricemia and a Network Perspective in Analyzing Factors Related to Hyperuricemia

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