The Predictive Value of Ki-67 Before Neoadjuvant Chemotherapy for Breast Cancer: A Systematic Review and Meta-Analysis

Chen, Xianyu; He, Chao; Han, Dongdong; Zhou, Meirong; Wang, Quan; Tian, Jinhui; Li, Lun; Xu, Feng; Zhou, Enbo; Yang, Kehu

doi:10.2217/fon-2016-0420

Cited by 96 publications

(86 citation statements)

References 54 publications

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“…Furthermore, progesterone receptor-negative status has been reported to independently predict pCR in HER2-positive tumors [5]. A recent meta-analysis found high Ki67 before neoadjuvant chemotherapy to be associated with higher rates of pCR [6]. Our patient had several of the aforementioned features associated with a higher likelihood of pCR, including clinical T1, albeit multifocal, disease, Grade 3 histology, negative progesterone receptors, high Ki67 index, HER2 positivity, and receipt of preoperative trastuzumab and one cycle of taxane.…”

Section: Discussionmentioning

confidence: 99%

Acute Inflammatory Response During Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Case Report

Feng

Berrang

McGhie

et al. 2017

Cureus

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We report on a 56-year-old Caucasian female, diagnosed with locally advanced, hormone-receptor-positive, and human epidermal growth factor receptor 2 (HER2)-positive cancer of the left breast. The patient received neoadjuvant chemotherapy with adriamycin/cyclophosphamide (AC) followed by docetaxel/trastuzumab. A partial clinical and radiographical response was documented after four cycles of AC. Approximately one week after the first cycle of docetaxel and trastuzumab, the patient presented with diffuse edema, erythema, and induration involving the entire left breast. The differential diagnoses included infection, inflammatory response/reaction to docetaxel, or cancer progression. After a multidisciplinary review, the decision was made to stop the docetaxel and deliver neoadjuvant radiation treatment concurrent with trastuzumab. Approximately four weeks after radiation therapy completion, the patient underwent a left total mastectomy and axillary dissection, with pathologic complete response (pCR) in the breast and axillary nodal disease. After surgery, systemic therapy was resumed with paclitaxel and trastuzumab, with a plan to start adjuvant endocrine therapy after completion of chemotherapy. We will discuss clinical considerations in the management of the unexpected findings of acute inflammatory response in the breast and nodal regions during neoadjuvant chemotherapy. Associations between intrinsic breast cancer subtype and pCR in locally advanced breast cancer will also be reviewed.

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Section: Discussionmentioning

confidence: 99%

Acute Inflammatory Response During Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Case Report

Feng

Berrang

McGhie

et al. 2017

Cureus

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“…It has a variability of the thresholds used to define a high Ki-67. For some authors, Ki-67 is positive from 5% to 34%, or even more [18,56]. This variability is related to a lack of standardization of the methodology for the evaluation of Ki-67 [56,61].…”

Section: Cut Off Of Ki-67mentioning

confidence: 99%

“…In this study, the Cut off of 20% was considered as proposed by the conference of St. Gall in 2013 [33]. This value is the most used in terms of prognosis [18]. So taking a cut off 20%, 55.8% of tumors had a Ki-67 > 20% in this study.…”

Section: Cut Off Of Ki-67mentioning

confidence: 99%

“…There is a statistically significant association between the tumor size of and the Ki-67. If some studies do not find association between the tumor size and the Ki-67 [34], others however attest it [2,18,37,45,67]. It is well known that during the evolution, mutations may induce cancer phenotype.…”

Section: Ki-67 and Stage Of The Diseasementioning

confidence: 99%

“…In addition to the predictive value of Ki-67 [18,19,42,54,55,64], the prognostic significance of this protein in breast cancer of the Western women has been reported [4,19,21,40,47,80]. Moreover, the proliferation has a major impact on calculating the risk of recurrence [27].…”

Section: Introductionmentioning

confidence: 99%

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Expression of Ki-67 and Prognosis of Breast Invasive Carcinoma in Congolese Women

Guy¹

2018

IJCOCR

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Breast invasive carcinoma is the most cancer in the world. In low resource countries, cancer are of poor prognosis for they are diagnosed at later stage. There is not a cancer registry in the Democratic Republic of Congo and studies on biomarkers are lacking. This study had the main purpose to determine the expression of Ki-67 and the prognosis of invasive breast carcinoma in Congolese women. Cross-sectional study of 86 women with invasive Breast Carcinoma were included in the Democratic Republic of Congo from Kinshasa (n=73) and Lubumbashi Cities (n= 13). Age at the time of diagnosis, tumor size, tumor necrosis, grade of tumor and proliferation index measured by Ki-67 were taken into account. Statistical analysis used SPSS program and Pearson Chi-square test. From 2014 to 2016, biopsies were collected from 86 Congolese patients to determine the expression of Ki-67 and the prognosis of invasive breast carcinoma. The proliferation marker was observed in 91.9%. K-i67 > 20% and > 30% were found respectively in 55.8% and in 33.7% of patients. The value of the Ki-67 was influenced by the tumor stage. The association between the size of the tumor and Ki-67 was statistically significant. The risk of tumor necrosis was 2.9 times in case of tumor with positive Ki-67. Ki-67 was positive in many patients younger than 45 years. However, the difference was not statistically significant. In patients with T3 and T4 tumors, the risk of positive Ki-67 was 7 times compared to those of T1 and T2 tumors. Patients with G3 tumors had 9 times the risk to have positive Ki-67 compared to those with G1 and G2 tumors. In conclusion, tumors in Congolese women are associated with higher proliferation index and poor prognosis for most of them are diagnosed at later stage. Chemotherapy can be justified for prior care in low resource countries and radical mastectomy should be encouraged.

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Synthesis, DNA‐/bovine serum albumin‐binding affinity, and cytotoxicity of dinuclear platinum(II) complexes with 1,6‐naphthyridine‐bridging ligand

Konovalov

Franich

Jurišević

et al. 2020

Applied Organom Chemis

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The dinuclear platinum(II) complexes, [{PtCl(NH 3) 2 } 2 (μ-1,6-nphe)](ClO 4) 2 (Pt1) and [{Pt(en)Cl} 2 (μ-1,6-nphe)](ClO 4) 2 (Pt2) (en is a bidentate-coordinated ethylenediamine and 1,6-nphe is the bridging 1,6-naphthyridine ligand) were synthesized and characterized by different spectroscopic methods. The DNAbinding evaluation of complexes Pt1 and Pt2 was done by UV-Vis, fluorescence emission spectroscopy, and their interaction with bovine serum albumin (BSA). The cytotoxic activity of these complexes was determined against mouse breast (4T1) and colon (CT26) cancer cell lines, human breast (MDA-MB-468), colon (HCT-116), and lung (A549) cancer cell lines as well as mouse mesenchymal stem cells (mMSC). Complex Pt1 showed higher cytotoxic capacity toward solid cancer cell lines compared with Pt2 and lower cytotoxic capacity toward mMSC cells compared with cisplatin. Furthermore, molecular mechanism studies showed that Pt1 complex induced 4T1 and A549 cell apoptosis therefore increasing expression of pro-apoptotic caspase-3 and decreasing expression of anti-apoptotic Bcl-2 and Ki-67. Antitumor capacity of Pt1 complex might be manifested at least in two ways: by facilitating apoptosis and by inhibiting tumor cells proliferation.

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The Predictive Value of Ki-67 Before Neoadjuvant Chemotherapy for Breast Cancer: A Systematic Review and Meta-Analysis

Abstract: High Ki-67 before NAC was a predictor for pCR in neoadjuvant setting for breast cancer patients.

Cited by 96 publications

References 54 publications

Acute Inflammatory Response During Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Case Report

Acute Inflammatory Response During Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Case Report

Expression of Ki-67 and Prognosis of Breast Invasive Carcinoma in Congolese Women

Synthesis, DNA‐/bovine serum albumin‐binding affinity, and cytotoxicity of dinuclear platinum(II) complexes with 1,6‐naphthyridine‐bridging ligand

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