The predictive value of incidental PET/CT findings suspicious for breast cancer in women with non-breast malignancies

Role of combined BI-RADS assessment using mammography and sonography for evaluation of incidental hypermetabolic lesions in the breast on 18F-FDG PET-CT

“…The former reflects the lower incidence of breast cancer in Korea (25), and the latter may be related to subjective visual assessment by the three nuclear medicine physicians. The malignancy rate in the current study was lower than that in other reports (37.5-83.3%) (16)(17)(18)(19)(20). This might be due to a higher proportion of excluded patients (23.3 vs. 0-9.0%) who underwent no histologic confirmation or insufficient follow-up.…”

“…The incidence of incidental hypermetabolic lesions in the current study was lower than that of the Western population (0.8-1.1%) but higher than that of the Korean population (0.4%) (16)(17)(18)(19)(20). The former reflects the lower incidence of breast cancer in Korea (25), and the latter may be related to subjective visual assessment by the three nuclear medicine physicians.…”

Multicentric study on 18F-FDG-PET/CT breast incidental uptake in patients studied for non-breast malignant purposes

“…[9][10][11][12][13][14][15][16][17][18][19][20][21][22] Results on the prevalence of BIU and their malignancy rate in the most important studies and in the present are summarised in Table 1 The nodule at CT was 20 mm of diameter, SUV max was 2.7, BIU to liver ratio was 0.9 and BIU to blood-pool ratio was 0.5. After biopsy the final diagnosis was fibroadenoma.…”

“…Wang et al 22 found 3 BIUs among 1727 patients which resulted to be infiltrating ductal carcinoma in 2 cases and 1 fibroadenoma. Beatty et al 12 evaluated 902 women identifying 9 patients with BIU, 5 with biopsy-proven invasive ductal carcinoma, 2 fibroadenoma, 1 no tumour, and 1 lost to follow-up. In the study of Litmanovich et al 13 BIU was identified in 33 of 4038 patients (0.8%) and followup data were available for 30 patients; 17 lesions were diagnosed as malignant while 13 foci were defined as benign.…”

“…8 Despite screening procedures, the available data reporting BIU detected by 18 F-FDG-PET or PET/CT suggest that some lesions are still missed during traditional screening work-up. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] When a BIU is detected, it creates for a management dilemma requiring further investigations. Overall, the prevalence of BIU on all scan ranges from 0.11% to 0.83%, with pooled estimate of 0.40%; the prevalence of BIU on scans performed on female patients only ranges from 0.36% to 1.84%, with pooled estimate of 0.82%; the pooled malignancy risk of BIU who undergo further investigations ranges from 18% to 100% with pooled estimate of 48%; the pooled malignancy risk of BIU who undergo histological examination ranges from 51% to 100% with pooled estimate of 60%.…”