The predictive value of electrocardiographic polarization parameters on appropriate ICD shock in primary prevention heart failure patients

Ozgul, Ufuk; Turan, Oğuzhan Ekrem; Başkurt, Ahmet Anıl; Yilancioglu, Reşit Yiğit; Doğduş, Mustafa; Inevi, Umut Dursun; Özcan, Emin Evren

doi:10.1016/j.jelectrocard.2022.10.008

Cited by 1 publication

(1 citation statement)

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“…The Tp-e/QT ratio appears to be more reliable than the QT and Tp-e intervals as an indicator of ventricular repolarization distribution 11 . Increased Tp-e and Tp-e/QT ratios have been reported to predict appropriate ICD shocks as well as indicate an increased risk of ventricular arrhythmia in HF patients with ICDs for primary prevention 16,17 . The addition of SGLT2 inhibitors to optimal medical therapy has been shown to positively affect ventricular repolarization markers 18 .…”

Section: Introductionmentioning

confidence: 99%

Effect of sacubutril/valsartan on Tp-e, QT, QTc, Tp-e/QTc parameters in heart failure with reduced ejection fraction

Genç,

Yılmaz Öztekin

2024

Cukurova Medical Journal

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Purpose: The purpose of this study is to evaluate ventricular repolarization before, at the first month, and sixth month after Sacubutril/Valsartan, an angiotensin receptor neprilysin inhibitor (ARNI) treatment in heart failure patients with reduced ejection fraction (HFrEF). Materials and Methods: We included 49 patients with HFrEF who switched to ARNI therapy. The 12-lead electrocardiography (ECG) was evaluated before ARNI therapy and also during the first and sixth months of the therapy. We evaluated demographic, clinical, and laboratory parameters, as well as medications and ECG data, including heart rate. Additionally, we examined QT, QTc, Tp-e, Tp-e calculated (Tp-ec), Tp-ec/QTc, Tp-e/QT, and Tp-e/QTc. Results: After receiving ARNI treatment, ventricular repolarization indices were significantly reduced in the first and sixth months compared to before treatment. Specifically, the QTc values decreased from 457.6 ms to 443.8 ms, and the Tp-e/QT ratio decreased from 0.21±0.03 to 0.19±0.03. Additionally, the QTc values decreased from 457.6 ms to 444.9 ms, and the Tp-e/QT ratio decreased from 0.21±0.03 to 0.18±0.03. However, when the first and sixth months under ARNI treatment were compared, no significant difference was found (QTc: 443.8 ms vs. 444.9 ms, Tp-e/QT: 0.19±0.03 vs. 0.18±0.003). Conclusion: ARNI treatment in HFrEF positively affected QTc, Tp-e, and Tp-ec intervals and Tp-e/QT, Tp-e/QTc, and Tp-ec/QTc ratios, which are indicators of ventricular repolarization. Moreover, this effect started in the first month and continued in the sixth month.

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Section: Introductionmentioning

confidence: 99%