The Predictive Value of Circulating Anti-Müllerian Hormone in Women With Polycystic Ovarian Syndrome Receiving Clomiphene Citrate: A Prospective Observational Study

Abstract

PCOS women with high circulating AMH (≥ 3.4 ng/mL) seem to be resistant to CC and may require a higher starting dose.

Prediction of Ovarian Response by Antimullerian Hormone in Women with Polycystic Ovarian Syndrome: A Randomized Prospective Study

“…Our findings are in agreement with previous article by Mahran A and co-workers [21], who have assessed the impact of serum AMH on the success rate of clomiphene citrate ovulation stimulation in 60 patients with anovulatory PCOS in 187 cycles of therapy, and found serum AMH concentrations to be negatively related to the chances of ovulation. Similarly, Amer SA et al [19], have assessed the effect of serum AMH levels on the outcome of ovarian induction in 20 women with anovulatory PCOS receiving 34 cycles of gonadotrophin regimens.…”

“…This cutoff is higher two times than those of previously mentioned by Mahran et al [21], who demonstrated that 3.4 ng/ml was an optimal cut-off among 60 women with PCOS. It is not impossible that different kits for detecting AMH may result in substantial difference in the serum concentration of AMH.…”

“…The current study was conducted on 300 women presented at infertility clinic of Ain Shams Maternity Hospital, during the period between Jan 2013 and Jan 2016 and included 300 women who were It is proved that in anovulatory women with PCOS, the higher level of serum FSH level may decrease the AMH excess, so decreasing its inhibitory effect on the follicular development, and allowing the development of a dominant follicle [21]. In ovulation stimulation, it is aimed to reach the development of a single dominant follicle.…”

Will emerging pharmacotherapies improve the management of polycystic ovarian syndrome?

“…[3] A modern approach for predicting patient's sensitivity to CC is represented by the AMH measurement. [12] Some authors suggest that an AMH cutoff of 1.2 ng/ ml could be used to predict CC response in obese PCOS women, [13] whereas Maharam et al [12] demonstrated that anovulatory women with AMH greater than 3.4 ng/ ml are resistant to CC and obtain increased ovulation rate with higher starting dose. Furthermore, patients with very high AMH levels may not be suitable for CC treatment and could therefore be directly switched to more effective treatments, such as gonadotrophin ovarian stimulation.…”

“…Furthermore, patients with very high AMH levels may not be suitable for CC treatment and could therefore be directly switched to more effective treatments, such as gonadotrophin ovarian stimulation. [12] 2.2.2.2. Metformin.…”