The predictive role of TLR4 +3725 G/C polymorphism in community-acquired pneumonia (CAP) severity course among young respondents with cytomegaloviral persistence (CMVP)

Chichirelo-Konstantynovych, Kiarina; Мороз, Л. В.; Konstantynovych, Tetyana

doi:10.1183/13993003.congress-2018.pa4226

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“…It confirms the hypothesis of multifunctional mechanisms of CMVI influence into the immunological status of patients and the launch of prognostic adverse effects in CAP course. [2122] The differences of clinical manifestations between CMVI-positive and CMVI-negative CAP patients fully confirm this hypothesis. clinical signs of CAP (cough and sputum) and objective data (percussion and auscultation phenomena) are much more extensive in individuals with CMVI-positive markers, which are statistically proven ( P < 0.05).…”

Section: Discussionmentioning

confidence: 55%

Prognostic influence of toll-like receptor 4 gene polymorphism into community-acquired pneumonia course among young patients with cytomegalovirus persistence

Moroz

Chichirelo-Konstantynovych

Konstantynovych

et al. 2019

Lung India

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Objectives: The aim of this study was to determine the predictive role of TLR4 polymorphism in CAP course among young cytomegalovirus-positive patients. Subjects and Methods: One hundred and five patients with pneumonia (age range: 18–44 years) and 61 healthy respondents were observed clinically and specifically (by cytomegalovirus markers and TLR4 + 3725 G/C polymorphism). Results: Among CAP patients, there were 51 male (48.6%) and 54 female (51.4%), with average age 34.1 ± 0.8 years, and there were 19 (18.1%) patients with Pneumonia Patient Outcomes Research Team (PORT) I, 46 (43.8%) patients with PORT II, 31 (29.5%) patients with PORT III, and 9 (8.6%) patients with PORT IV. Cytomegalovirus persistence was detected in 80 (48.2%) patients and 34 (20.5%) healthy respondents ( P = 0.003). G/G genotype of TLR4 signaling was found in 78 (74%) patients with pneumonia, G/C in 24 (23%) patients, and C/C in 3 (3%) patients. Among G/C patients, there were 16.2% cytomegalovirus-positive patients versus 6.7% negative patients ( P < 0.05), as well as among G/G patients, and there were 59% versus 15,2%, accordingly ( P < 0.01). The patients of the main group with G/G genotype were characterized by mostly mild (PORT I – 15 [14.3%]) and moderate pneumonia severity (PORT II – 32 [30.5%] and PORT III – 26 [24.8%] patients). The patients with G/C genotype were characterized by mostly PORT II (11 [10.5%] patients). All C/C genotype patients have PORT II ( P < 0.05). Conclusions: Cytomegalovirus persistence worsens the pneumonia course. G/G and G/C TLR4 genotypes are associated with mild pneumonia severity.

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Section: Discussionmentioning

confidence: 55%