The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis

Abstract

BackgroundBrucellosis is a zoonosis that affects several systems, especially with the osteoarticular involvement.ObjectivesThis study aims to compare the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), mean platelet volume (MPV) and red blood cell distribution (RDW) in patients with the osteoarticular involvement and those with non-localised brucellosis and evaluate their predictive value for the diagnosis of osteoarticular brucellosis.MethodsWe enrolled 140 patients with brucellosis, 70 with the osteoarticular involvement and 70 without any localised involvement. We collected patients' data retrospectively and compared haematological parameters between both groups. In patients with osteoarticular brucellosis, a correlation of the NLR with the ESR and CRP and correlation of the MLR with the ESR and CRP were assessed. Furthermore, the predictive performance of the ESR, CRP, NLR and MLR on the osteoarticular involvement was evaluated.ResultsThe NLR, MLR, ESR, CRP, neutrophil and monocyte levels were higher in the patient group than the control group.ConclusionThe NLR, MLR, ESR and CRP are useful parameters to estimate the clinical course of patients with brucellosis, and the NLR and MLR are alternative to inflammatory markers in the osteoarticular involvement.

<p>Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis</p>

“…21 A study in Turkey reported that the level of CRP was higher in osteoarticular brucellosis patients than in non-osteoarticular brucellosis patients. 22 Another study reported that patients with the acute brucellosis exhibited higher CRP levels than the control group. 6,13,23 Some other studies have suggested that elevated CRP level may also be associated with disease severity and mortality in hospitalized patients with community-acquired pneumonia.…”

Evaluation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio in patients with cellulitis

“…An increase in the NLR and a decrease in the LMR are considered indicators of systemic inflammation. Several studies have indicated that NLR, PLR, and LMR may predict systemic inflammation, and these markers may be useful in many diseases [13][14][15] . Horne et al 16 reported that NLR is more effective than leukocyte levels in predicting inflammation.…”

“…Studies investigating the role of peripheral blood leukocyte rates in predicting complications and prognosis in various diseases reported that PLR and NLR rates can be used as prognostic markers with diagnoses. For example, two different studies revealed higher NLR rates in patients requiring amputation in diabetic foot infections and in those with osteoarticular involvement in brucella infection 14,18 . Yapici et al 19 showed in their study that the NLR values of patients who had diabetic foot infection with concurrent osteomyelitis were significantly higher than those without osteomyelitis (p = 0.004).…”

Serum level of vitamin D, CRP and biochemical parameter in acute and chronic brucellosis treated with doxycycline-loaded solid lipid nanoparticles

“…Due to the fact that brucellosis affects the vital organs of the body, including the liver, spleen, joints, etc., their function is impaired and increases or decreases various enzymes and proteins in the body [16]. In some studies, using electrophoresis of proteins in the serum, serum levels of proteins change during infectious diseases that are associated with long-term in ammation.…”