The Predictive Role of a Novel Risk Index in Patients Undergoing Carotid Artery Stenting: Systemic Immune-Inflammation Index

Keskin, Muhammed; Öcal, Lütfi; Çerşit, Sinan; Yılmaz, Cemalettin; Küp, Ayhan; Çelık, Mehmet; Doğan, Selami; Koyuncu, Atilla; Kaya, Adnan; Türkmen, Mustafa

doi:10.1016/j.jstrokecerebrovasdis.2021.105955

Cited by 9 publications

(10 citation statements)

References 34 publications

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“…As a lipid-driven inflammatory disease, atherosclerosis emerges from an imbalance between proinflammatory and inflammation-resolving mechanisms. Different markers can represent the inflammatory response, including the systemic immune-inflammatory index, which has gained interest in recent studies as a reliable predictor [31]. We found preoperative SII values above 665 to be significant in the univariable model for mortality prediction.…”

Section: Discussionmentioning

confidence: 70%

The Significance of Systemic Immune-Inflammatory Index for Mortality Prediction in Diabetic Patients Treated with Off-Pump Coronary Artery Bypass Surgery

et al. 2022

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Diabetes mellitus (DM) represents a complex carbohydrate metabolism disorder characterized by inflammatory over-reactivity. The study aimed to investigate the potential influence of postoperative inflammatory activation on mortality risk after off-pump coronary artery bypass grafting in diabetic patients. There were 510 patients treated with off-pump coronary artery bypass grafting due to stable complex coronary artery disease, including 175 patients with type-2 DM (T2DM.) The mean follow-up time was 3.7 +/− 1.5 years with a 9% all-cause mortality rate in the diabetic group. In multivariable analysis, preoperative comorbidities (stroke, peripheral artery disease, postoperative systemic inflammatory index >952, and postoperative left ventricle ejection fraction (LVEF) < 45%) were revealed as prognostic factors. The receiver operator characteristics curve analysis for postoperative calculations of systemic immune-inflammatory index (SII) appeared significant (AUC = 0.698, p = 0.008), yielding sensitivity of 68.75% and specificity of 71.07%. Systemic immune-inflammatory index (SII) can be regarded as a predictive marker for long-term prognosis in diabetic patients after off-pump coronary artery bypass grafting. The role of perioperative inflammatory activation may play a crucial role in mortality prediction.

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Section: Discussionmentioning

confidence: 70%

The Significance of Systemic Immune-Inflammatory Index for Mortality Prediction in Diabetic Patients Treated with Off-Pump Coronary Artery Bypass Surgery

et al. 2022

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“…[9][10][11][12][13] A new inflammation marker, the systemic immuneinflammation index (SII), plays a significant role in predicting the severity and prognosis of many illnesses, including cardiovascular diseases. [14][15][16][17][18][19][20] It has been shown in several studies that it is a more accurate indicator than neutrophil count, lymphocyte count, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) alone and/or together. [14][15][16][17][18][19][20] However, the correlation between SII levels and CAS severity has not been established.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17][18][19][20] It has been shown in several studies that it is a more accurate indicator than neutrophil count, lymphocyte count, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) alone and/or together. [14][15][16][17][18][19][20] However, the correlation between SII levels and CAS severity has not been established. Therefore, the present study investigated the link between SII and CAS severity evaluated by carotid artery angiography (CAAG).…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Systemic Immune-Inflammation Index is Independently Associated With Severity of Carotid Artery Stenosis

et al. 2022

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Stroke is a significant contributor to morbidity and mortality. The present study investigated how the systemic immune inflammation index (SII) could be used to predict the likelihood of developing carotid artery stenosis (CAS), which can be seen using carotid artery angiography (CAAG). This study comprised 418 individuals who underwent CAAG for CAS. SII was calculated by multiplying the platelet count by the neutrophil/lymphocyte ratio (NLR). The patients were divided into two groups: non-critical and critical CAS (stenosis below %70 and above ≥70%, respectively). Compared with the non-critical CAS, the critical CAS group had greater high sensitivity C-reactive protein levels (4.5 [3.1-5.7] vs 3.9 [2-5] [mg/L], P < .001), NLR (4.1 [2.9-7.5] vs 2.9 [1.8-3.7], P < .001), platelet/lymphocyte ratio (233 [110-297] vs 119 [96-197], P < .001), and SII (860 [608-2455] vs 604 [458-740], P < .001). Receiver Operating Characteristic Curve analysis demonstrated the best cutoff value of 672.3 for SII to predict the critical CAS with 71.2% sensitivity and 60.1% specificity. According to our study, an increase in SII is an independent predictor of the severity of CAS in patients undergoing CAAG.

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“…Neutrophils, the core of innate immunity, 14,20,26,27 . Platelet is also one of the components constituting innate immunity, and activated platelets can also contribute to neuronal cell death to some extent 20,27,28 . In adaptive immunity, lymphocytes promote healing of damaged tissues through the secretion of substances such as interleukin-10 14,28 .…”

Section: Discussionmentioning

confidence: 99%

Systemic immune-inflammation index is associated with white matter hyperintensity volume

Nam

Kwon

Jeong

et al. 2022

Sci Rep

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Systemic immune-inflammation index (SII) is a novel inflammatory marker based on the composition ratio of blood cell counts. In this study, we evaluated the association between the SII and cerebral small vessel disease (cSVD) in health check-up participants. We evaluated participants from our health check-up registry between 2006 and 2013. The SII was calculated using the following formula: SII = (platelet count × neutrophil count)/lymphocyte count. cSVD was assessed by considering white matter hyperintensity (WMH) volume, lacunes, and cerebral microbleeds (CMBs). A total of 3187 participants were assessed. In multivariable linear regression analysis, the SII was significantly related to WMH volume [β = 0.120, 95% confidence interval (CI) 0.050–0.189]. However, lacunes and CMBs showed no statistical significance with the SII. In the subgroup analysis by age, the SII was significantly associated with WMH volume only in participants aged ≥ 60 years (β = 0.225, 95% CI 0.068–0.381). In conclusion, a high SII was associated with cSVD. Since this association was more pronounced in WMH than in lacunes or CMBs, WMH might be closer to the inflammation-related pathological mechanisms.

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The Predictive Role of a Novel Risk Index in Patients Undergoing Carotid Artery Stenting: Systemic Immune-Inflammation Index

Cited by 9 publications

References 34 publications

The Significance of Systemic Immune-Inflammatory Index for Mortality Prediction in Diabetic Patients Treated with Off-Pump Coronary Artery Bypass Surgery

The Significance of Systemic Immune-Inflammatory Index for Mortality Prediction in Diabetic Patients Treated with Off-Pump Coronary Artery Bypass Surgery

Increased Serum Systemic Immune-Inflammation Index is Independently Associated With Severity of Carotid Artery Stenosis

Systemic immune-inflammation index is associated with white matter hyperintensity volume

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