The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy

Wang, Yu; Shao, Yi; Shi, Wen‐Qing; Jiang, Lei; Wang, Xiaoyu; Zhu, Pei‐Wen; Yuan, Qing; Gao, Ge; Lv, Jiannan; Wang, Gongxian

doi:10.1007/s13167-019-00171-4

Cited by 22 publications

(22 citation statements)

References 66 publications

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“…In patients with binocular blindness, the volume of local gray matter in the precuneus is reduced [53] . Other studies have shown that in normal-tension glaucoma [54] , diabetic retinopathy [55] , primary angle-closure glaucoma [30] and other diseases, the precuneus shows spontaneous reduction of brain activity, which is consistent with our research. The conclusions are the same, and the results of the study are also consistent with the clinical manifestations of SA children with eye movement disorders and abnormal visual spatial imaging.…”

Section: Analysis Of the Decreased Falff In Patsupporting

confidence: 93%

Children with Strabismus and Amblyopia Presented Abnormal Spontaneous Brain Activities Measured Through Fractional Amplitude of Low-Frequency Fluctuation (fALFF)

Liu

Shi

Liang

et al. 2021

Preprint

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Purpose Based on fMRI technology, we explored whether children with strabismus and amblyopia (SA) showed significant alteration in fractional amplitude of low-frequency fluctuation (fALFF) values in specific brain regions compared with healthy controls, and whether this change could indicate the clinical manifestations and pathogenesis of children with strabismus to a certain extent. Methods 23 children with strabismus amblyopia and same number matched healthy control was registered in the ophthalmology department of the First Affiliated Hospital of Nanchang University, and the whole brain was scanned by rs-fMRI. The fALFF value of each brain area was derived to explore whether there is a statistical difference in the two groups. Meanwhile, ROC curve was made in a view to evaluate whether this difference is of value as a diagnostic index. Finally, analyze whether the changes in the fALFF value of some specific brain regions are related to clinical manifestations Results report to HCs children with SA presented a decreased fALFF values in left temporal pole: the superior temporal gyrus, right middle temporal gyrus, right superior frontal gyrus, right supplementary motor area. Meanwhile, they also showed higher fALFF values in specific brain areas, which included left precentral gyrus, left inferior Parietal, left Precuneus. Conclusion Children with SA showed abnormal fALFF values in different brain regions. Most of these regions were allocated to the visual formation pathway. The eye movement-related pathway or other visual-related pathways, suggesting the pathological mechanism of the patient.

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Section: Analysis Of the Decreased Falff In Patsupporting

confidence: 93%

Children with Strabismus and Amblyopia Presented Abnormal Spontaneous Brain Activities Measured Through Fractional Amplitude of Low-Frequency Fluctuation (fALFF)

Liu

Shi

Liang

et al. 2021

Preprint

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“…First, the former meta-analysis included only five original studies and seven datasets that investigated the regional functional activity alterations using ALFF/fALFF and ReHo. Our study with a larger sample included 16 original studies and 19 datasets, and many of the newly included studies reported hypoactivity in the medial superior frontal gyrus (Liu et al, 2016;Wang et al, 2019;Shi et al, 2020;Zhang Y. Q. et al, 2020) and hyperactivity in the cerebellum (Liao et al, 2019;Wang et al, 2019;Qi et al, 2020;Shi et al, 2020;Zhang Y. Q. et al, 2020). Second, the previous meta-analysis included both regional activity and functional connectivity measurements as well as perfusion modality, whereas this meta-analysis enrolled only studies using ALFF/fALFF and ReHo indices reflecting the regional spontaneous neural activity, avoiding heterogeneity of the included studies (Xia et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 47 articles were identified through the systematic literature search, and Figure 1 shows the details of study selection process. We finally included 16 studies (19 T2DM datasets and 15 healthy controls datasets) in the final meta-analysis (Xia et al, 2013;Cui et al, 2014;Wang et al, 2014Wang et al, , 2019Zhou et al, 2014;Liu et al, 2016;Peng et al, 2016;Wang Y. F. et al, 2017;Wang Z. L. et al, 2017;Liao et al, 2019;Liu Y. et al, 2020;Qi et al, 2020;Shi et al, 2020;Xiong et al, 2020;Zhang Y. Q. et al, 2020). In two studies of ReHo, the analysis was performed in two different T2DM subgroups (Peng et al, 2016;Xiong et al, 2020), and in another study, the analysis was performed with ALFF and ReHo (Cui et al, 2014).…”

Section: Included Studies and Sample Characteristicsmentioning

confidence: 99%

Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies

Liu

Yang

et al. 2021

Front. Aging Neurosci.

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Objective: Resting-state functional magnetic resonance imaging (rs-fMRI) studies have revealed inconsistent regional spontaneous neural activity alterations in patients with type 2 diabetes mellitus (T2DM). The aim of our meta-analysis was to identify concordant regional spontaneous neural activity abnormalities in patients with T2DM.Methods: A systematic search was conducted to identify voxel-based rs-fMRI studies comparing T2DM patients with healthy controls. The permutation of subject images seed-based d mapping (SDM) was used to quantitatively estimate the regional spontaneous neural activity abnormalities in patients with T2DM. Metaregression was conducted to examine the associations between clinical characteristics and functional alterations.Results: A total of 16 studies with 19 datasets including 434 patients with T2DM and 391 healthy controls were included. Patients with T2DM showed hypoactivity in the right medial superior frontal gyrus, right superior temporal gyrus, and left lingual gyrus, whereas hyperactivity in the right cerebellum. Metaregression analysis identified negative correlation between regional activity in the medial superior frontal and anterior cingulate gyri and illness duration of patients with T2DM.Conclusion: The patterns of regional spontaneous neural activity alterations, characterized by hypoactivity in the medial pre-frontal cortex, visual cortex, and superior temporal gyrus, whereas hyperactivity in the cerebellum, might represent the underlying neuropathological mechanisms of T2DM.

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“…The medial section of the superior frontal gyrus (SFG), located in front of the paravertebral central lobule, passes forward through the cingulate gyrus [ 30 ]. It is mainly responsible for executive process and functions and is the basis of decision-making [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study

Shu

et al. 2021

Aging

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Objective: To investigate the changes of amplitude of low-frequency fluctuation (ALFF) in brain regions of patients with hypertensive retinopathy by using resting-state functional magnetic resonance imaging (rs-fMRI) and change in the relationship of ALFF value with potential emotional and psychological changes. Methods: Thirty-one patients with hypertensive retinopathy (HR) (16 men and 15 women) and 31 healthy controls (HCs; 16 men and 15 women) matched for age, sex, and weight were enrolled in the research. The changes in mean ALFF values could reflect brain activity between HR patients and HCs. We used the independent samples t-test to evaluate different demographic and general information between the two groups. Two-sample t-test was used to detect differences of mean ALFF values in the brain region between the two groups using the same software. Results: The ALFF values in the brain areas of HR and HCs were different. HR patients had lower ALFF value in the left medial superior frontal gyrus and left middle frontal gyrus than the HCs. The higher ALFF values were found in the cerebellum (left inferior and right superior lobes, vermis) and left inferior temporal gyrus of the HR patients than the controls. Conclusion: Our findings showed fluctuations in ALFF values in the HR patients’ brain regions. ALFF values reflect over or reduced activity in brain regions. Abnormal ALFF values in these brain areas can predict early HR development, preventing the malignant transformation of hypertensive microangiopathy.

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The predictive potential of altered spontaneous brain activity patterns in diabetic retinopathy and nephropathy

Cited by 22 publications

References 66 publications

Children with Strabismus and Amblyopia Presented Abnormal Spontaneous Brain Activities Measured Through Fractional Amplitude of Low-Frequency Fluctuation (fALFF)

Children with Strabismus and Amblyopia Presented Abnormal Spontaneous Brain Activities Measured Through Fractional Amplitude of Low-Frequency Fluctuation (fALFF)

Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies

Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study

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