The prediction of survival of patients with gastric cancer with PD-L1 expression using contrast-enhanced ultrasonography

Wang, Lin-Ang; Wei, Xi; Li, Qing; Lin, Chen

doi:10.1007/s13277-015-4600-y

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…However, for patients with GC, the association between the expression of PD-L1 and their prognosis remains controversial. Multiple studies have indicated that positive PD-L1 expression is associated with a significantly poor OS1617181920212223, but other studies could not confirm this finding2425.…”

Section: Discussionmentioning

confidence: 99%

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

Zhang

Dong

Liu

et al. 2016

Sci Rep

120

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The prognostic value of programmed death-ligand 1 (PD-L1) in gastric cancer (GC) remains controversial. To clarify this problem, we performed a meta-analysis of research studies identified in the PubMed, EMBASE and the Cochrane Library databases. A total of 1,901 patients in 10 studies were enrolled in this meta-analysis, and the pooled hazard ratio (HR) of 1.64 (95% CI 1.11 to 2.43; P = 0.01) indicated that PD-L1 expression is associated with a shorter overall survival (OS). The pooled odds ratios (ORs) indicated that PD-L1 expression was associated with tumour size (OR = 1.87, 95% CI 1.25 to 2.78; P = 0.002) and lymph node status (OR = 2.17, 95% CI 1.04 to 4.52; P = 0.04). However, PD-L1 had no correlation with gender, age, cancer location, differentiation, depth of invasion, and tumour stage. This meta-analysis indicates that PD-L1 expression is a valuable predictor of the prognosis of patients with GC. PD-L1 expression could be used for identifying a subgroup of patients, who would potentially benefit from targeted therapy against PD-1 or PD-L1. Well-designed large-cohort studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

Zhang

Dong

Liu

et al. 2016

Sci Rep

120

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“…CEUS offers an early evaluation of microvascular perfusion within the tumor lesions 16 and therefore plays an important role in the early diagnosis and prognostic prediction for many solid tumors. [17][18][19][20] However, CEUS is rarely used in hematologic malignancies, especially DLBCL. By comparing the quantitative parameters of CEUS across DLBCL patients in different clinical stages, we found that both PPT and WOT were significantly shortened in advanced DLBCL, while PI and AUC increased dramatically.…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma

Duan¹,

Zhang²,

Xu³

et al. 2022

CMAR

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Objective To investigate the predictive role of contrast-enhanced ultrasonography (CEUS) plus D-dimer levels in the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). Methods CEUS was applied to assess lymph nodes in 186 patients with confirmed DLBCL. The clinical data and laboratory indicators were collected from these patients, and a retrospective analysis was conducted on the relationship between the quantitative parameters of CEUS (TTP, PI, AUC, WOT), D-dimer levels, and clinical features of the DLBCL patients. The Cox regression model was used for univariate and multivariate analyses for the risk factors associated with the prognosis. Results There was an increase of D-dimer levels in advanced DLBCL patients, who were combined with a significant reduction in TTP and WOT and a significant increase in PI and AUC. D-dimer levels and quantitative parameters of CEUS were strongly correlated with the Ann Arbor, B symptoms, International Prognostic Index (IPI), LDH and CRP levels. The results of the Cox regression model indicated that D-dimer levels, TTP and PI, the quantitative parameters of CEUS, were important prognostic factors for DLBCL. Conclusion CEUS results and D-dimer levels can be used as independent prognostic factors for DLBCL.

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“…CEUS has several advantages; it is a well-tolerated noninvasive technique in contrast to the standard invasive upper gastrointestinal endoscopy and has a smaller ionizing burden than a computed tomography (CT) scan. This study pointed out the promising role of this imaging technique in predicting PD-L1 expression ( p = 0.0003) [95]. A recent meta-analysis comprised 10 studies with 1901 GC patients assessing PD-L1 expression, low OS ( p = 0.01), and poor clinicopathological status [96].…”

Section: Pd-1/pd-l1 and Ctla-4 Expression And Prognostic Rolementioning

confidence: 99%

Immunotherapeutic Strategies for Gastric Carcinoma: A Review of Preclinical and Clinical Recent Development

Abozeid

Rosato

Sommaggio

2017

BioMed Research International

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Gastric carcinoma (GC) is the 2nd most common cause of cancer-related death. Despite advances in conventional treatment and surgical interventions, a high percentage of GC patients still have poor survival. Recently, immunotherapy has become a promising approach to treat GC. Here, we present preclinical and clinical studies encouraging the use of vaccination, adoptive T-cell therapy (ACT), and immune checkpoint inhibitors, such as programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). The ongoing immunotherapy clinical trials have shown promising results in safety and tolerability even in late-stage GC patients. Moreover, we highlight that the combination of ACT with chemotherapy could be the best choice to treat GC.

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The prediction of survival of patients with gastric cancer with PD-L1 expression using contrast-enhanced ultrasonography

Cited by 9 publications

References 22 publications

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma

Immunotherapeutic Strategies for Gastric Carcinoma: A Review of Preclinical and Clinical Recent Development

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