The Prediction of Outcome in Chronic Schizophrenia

McGlashan, Thomas H.

doi:10.1001/archpsyc.1986.01800020077010

Cited by 117 publications

(30 citation statements)

References 53 publications

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“…In an older (mean age 43) birth cohort of the same region as the current study the family history of psychosis was not associated with occupational, social, clinical or global outcome in schizophrenia (Käkelä et al, 2017). Family history of schizophrenia or psychosis has been associated with more frequent or longer hospitalisation in schizophrenia in several studies (Erlenmeyer-Kimling and Nicol, 1969;McGlashan, 1986;Suvisaari et al, 1998;Dadić-Hero et al, 2013). So far the studies have focused on individuals with schizophrenia, and to our knowledge there are no studies examining all psychoses, and therefore studying all psychoses could bring new aspect to the matter.…”

Section: Introductionsupporting

confidence: 42%

Association between family history of mental disorders and outcome in psychotic disorders

Käkelä

Nordström

Haapea

et al. 2018

Psychiatry Research

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Highlights  The presence of any parental psychiatric disorder is associated with higher number of hospitalizations in psychotic disorders  The presence of parental psychosis is not associated with outcome in psychotic disorders  The study is based on a general population-based cohort with high coverage and reliable register data  The results should be interpreted with caution due to small sample size

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Section: Introductionsupporting

confidence: 42%

Association between family history of mental disorders and outcome in psychotic disorders

Käkelä

Nordström

Haapea

et al. 2018

Psychiatry Research

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“…Compared with other areas in medicine, EI is a relatively new concept in psychotic disorders, partly due to the previous pessimistic attitude towards treatment outcome. This attitude has been challenged by a series of studies in recent decades, which showed that recovery is possible and that early outcome predicts long-term outcome (McGlashan 1986;Thara et al 1994;Mason et al 1996;Harrison et al 1996;Carpenter and Strauss 1991;Harding et al 1987). These research efforts have led to the development of the critical period hypothesis, suggesting maximum plasticity (deterioration or amelioration) in the early phase of psychosis, during which biological and psychosocial influences have the greatest impact; this is followed by a plateau in long-term outcome (Birchwood, Todd, and Jackson 1998).…”

Section: Rationales and Goals In Ei Movementmentioning

confidence: 99%

Early intervention for psychotic disorders: Real-life implementation in Hong Kong

Wong

Hui

Tang

et al. 2012

Asian Journal of Psychiatry

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Hong Kong is among the first few cities in Asia to have implemented early intervention for psychosis in 2001. Substantial changes in psychosis service have since taken place. We reviewed available outcome data in Hong Kong, with reference to the philosophy of early intervention in psychosis, discussing experience and lessons learned from the implementation process, and future opportunities and challenges. Data accumulated in the past decade provided evidence for the benefits and significance of early intervention programmes: patients under the care of early intervention service showed improved functioning, milder symptoms, and fewer hospitalizations and suicides. Early intervention is more cost-effective compared with standard care. Stigma and misconception remains an issue, and public awareness campaigns are underway. In recent years, a critical mass is being formed, and Hong Kong has witnessed the unfolding of public service extension, new projects and organizations, and increasing interest from the community. Several major platforms are in place for coherent efforts, including the public Early Assessment Service for Young people with psychosis (EASY) programme, the Psychosis Studies and Intervention (PSI) research unit, the independent Hong Kong Early Psychosis Intervention Society (EPISO), the Jockey Club Early Psychosis (JCEP) project, and the postgraduate Psychological Medicine (Psychosis Studies) programme. The first decade of early intervention work has been promising; consolidation and further development is needed on many fronts of research, service and education.

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“…Concerning DUP, an increasing body of literature has unanimously identified a longer duration of psychosis, mostly of more than 1 year, prior to first treatment as being detrimental to outcome [32,55,57,62,[66][67][68][69][70][71][72][73] . The negative influence of family history of severe psychiatric disease was addressed by several researchers [20,[74][75][76] and less family history is consistently related to better outcome.…”

Section: Predictors Of Outcomementioning

confidence: 99%

One-Year Outcome and Its Prediction in First-Episode Schizophrenia – A Naturalistic Study

Bachmann¹,

Bottmer

Schröder

2007

Psychopathology

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Background: The literature suggests that the early course of schizophrenia is a strong predictor of long-term outcome. We sought to test this notion in a sample of first-episode patients. Sampling and Methods: Forty patients with a first episode of DSM-IV diagnoses of schizophrenia, schizoaffective, or schizophreniform disorder were assessed with well-established instruments such as the Positive and Negative Syndrome Scale and the Strauss-Carpenter Scale. Reassessment was performed 14 months later and included the Global Assessment of Functioning Scale in addition to the aforementioned instruments and a psychiatric interview. Regression analyses for the Global Assessment of Functioning Scale and symptomatology were used to identify outcome predictors. Results: At follow-up, 27 patients (67.5%) were in remission. Women’s outcome was significantly better with respect to intimate relationships and domiciliary independence. Although symptomatology of the whole group remained stable during the follow-up period, a subgroup of patients experienced a significant decrease in symptom levels whereas symptoms increased in another subgroup. The most important predictor of outcome was compliance with atypical antipsychotic medication during the follow-up period. Conclusions: These results suggest that there is a prognostic divide early in the course of the disease, that compliance with medication is of overriding importance towards 1-year outcome, and that for the individual patient the question of chronicity may be answered very early in the course of the disease.

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The Prediction of Outcome in Chronic Schizophrenia

Cited by 117 publications

References 53 publications

Association between family history of mental disorders and outcome in psychotic disorders

Association between family history of mental disorders and outcome in psychotic disorders

Early intervention for psychotic disorders: Real-life implementation in Hong Kong

One-Year Outcome and Its Prediction in First-Episode Schizophrenia – A Naturalistic Study

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