The Prediction and Function of Neoantigen in Oncobiology

Abstract

Abstract.Recent clinical data clearly demonstrated that patient's own immune system has great potential in controlling the progression of many human cancers. Neoantigen is the foundation of tumor immunology for it is the "marker" for mature autologous T lymphocytes to distinguish tumor cells and normal cells. So identification of neoantigen is an important work in both fundamental studies and clinical immunotherapies. Neoantigen is patient-specific, it is derived from tumor genome somatic mutations in protein coding region. Identification of neoantigen is a laborious work before, but recent technological innovations have made this measurement easier and faster, though still not perfect. Now, numerous neoantigen based clinical trials are being carried out around the world by both academic institutes and companies, some have achieved exciting results.