The preclinical stage of movement disorders

Localized vs. Systematic Neurodegeneration: A Paradigm Shift in Understanding Neurodegenerative Diseases

“…The categorization of neurodegenerative disorders have yet to be undertaken with regards to their mechanistic progression and their characteristic patterns of degeneration (Przedborski et al, 2003 ). Most of the categorization in this field is done with regards to patient's symptoms, their behavioral presentations, and deterioration (Reetz et al, 2010 ; Weintraub, 2011 ; Blesa et al, 2012 ; Rohrer et al, 2015 ; Eberhardt and Topka, 2016 ). Neurodegeneration and neurodegenerative diseases are one of the most researched and yet the most mysterious disorders in neuroscience.…”