The Preclinical Phase of Alzheimer Disease

Abstract

The "preclinical phase" of detectable lowering of cognitive functioning precedes the appearance of pAD by many years. Measures of retention of information and abstract reasoning are among the strongest predictors of pAD when the interval between initial assessment and the development of pAD is long. Arch Neurol. 2000.

Cognitive impairment in preclinical Alzheimer's disease: A meta-analysis.

“…These findings are consistent with claims made by many investigators in this field (e.g., Bäckman, Small, & Fratiglioni, 2001; Elias et al, 2000; Grober & Kawas, 1997; Linn et al, 1995; B. J.…”

Cognitive impairment in preclinical Alzheimer's disease: A meta-analysis.

“…These findings are consistent with claims made by many investigators in this field (e.g., Bäckman, Small, & Fratiglioni, 2001; Elias et al, 2000; Grober & Kawas, 1997; Linn et al, 1995; B. J.…”

Cognition and Incident Dementia Hospitalization: Results from the Atherosclerosis Risk in Communities Study

“…Our results are consistent with previous studies that have shown an association between cognitive test score(s) and short-term risk of dementia in mostly older adults [4–7] and long-term risk of dementia in predominantly younger or middle-aged adults [1–3, 8, 9]. However, previous studies have been limited by a single assessment of cognitive function [1–3], short length of follow-up [4–7], or study populations limited primarily to the elderly [1, 4–8].…”

Associations Between Midlife Functional Limitations and Self-Reported Health and Cognitive Status: Results from the 1998–2016 Health and Retirement Study

“…Our first finding highlighted limitations in IADLs in midlife as specific factors for higher relative risks for both CIND and dementia in later life. Our results were in line with previously published studies linking midlife IADL limitations and diagnosis of CIND and dementia [20,[44][45][46]. A recent study by Edwards and colleagues examining US individuals ages 55 years and older found that 50% of females and 40% of males with CIND or dementia reported having some disability [47].…”

Cognitive impairment in preclinical Alzheimer's disease: A meta-analysis.

“…These findings are consistent with claims made by many investigators in this field (e.g., Bäckman, Small, & Fratiglioni, 2001; Elias et al, 2000; Grober & Kawas, 1997; Linn et al, 1995; B. J.…”

Cognition and Incident Dementia Hospitalization: Results from the Atherosclerosis Risk in Communities Study

“…Our results are consistent with previous studies that have shown an association between cognitive test score(s) and short-term risk of dementia in mostly older adults [4–7] and long-term risk of dementia in predominantly younger or middle-aged adults [1–3, 8, 9]. However, previous studies have been limited by a single assessment of cognitive function [1–3], short length of follow-up [4–7], or study populations limited primarily to the elderly [1, 4–8].…”

Associations Between Midlife Functional Limitations and Self-Reported Health and Cognitive Status: Results from the 1998–2016 Health and Retirement Study

“…Our first finding highlighted limitations in IADLs in midlife as specific factors for higher relative risks for both CIND and dementia in later life. Our results were in line with previously published studies linking midlife IADL limitations and diagnosis of CIND and dementia [20,[44][45][46]. A recent study by Edwards and colleagues examining US individuals ages 55 years and older found that 50% of females and 40% of males with CIND or dementia reported having some disability [47].…”

Cognitive impairment in preclinical Alzheimer's disease: A meta-analysis.

“…These findings are consistent with claims made by many investigators in this field (e.g., Bäckman, Small, & Fratiglioni, 2001; Elias et al, 2000; Grober & Kawas, 1997; Linn et al, 1995; B. J.…”

Cognition and Incident Dementia Hospitalization: Results from the Atherosclerosis Risk in Communities Study

“…Our results are consistent with previous studies that have shown an association between cognitive test score(s) and short-term risk of dementia in mostly older adults [4–7] and long-term risk of dementia in predominantly younger or middle-aged adults [1–3, 8, 9]. However, previous studies have been limited by a single assessment of cognitive function [1–3], short length of follow-up [4–7], or study populations limited primarily to the elderly [1, 4–8].…”

Associations Between Midlife Functional Limitations and Self-Reported Health and Cognitive Status: Results from the 1998–2016 Health and Retirement Study

“…Our first finding highlighted limitations in IADLs in midlife as specific factors for higher relative risks for both CIND and dementia in later life. Our results were in line with previously published studies linking midlife IADL limitations and diagnosis of CIND and dementia [20,[44][45][46]. A recent study by Edwards and colleagues examining US individuals ages 55 years and older found that 50% of females and 40% of males with CIND or dementia reported having some disability [47].…”