The preclinical and clinical activity of aviscumine: A potential anticancer drug

Zwierzina, Heinz; Bergmann, Lothar; Fiebig, H.H.; Aamdal, Steinar; Schöffski, Patrick; Witthohn, Klaus; Lentzen, Hans

doi:10.1016/j.ejca.2011.02.022

Cited by 44 publications

(30 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high IFN-γ response indicates that rML administration stimulates Th1 cells, which may mediate an antitumor T-cell response (reviewed by Zwierzina et al . [19]).…”

Section: Overview Of Immunomodulatory Plant Lectinsmentioning

confidence: 99%

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

et al. 2013

View full text Add to dashboard Cite

Advances in the glycobiology and immunology fields have provided many insights into the role of carbohydrate-protein interactions in the immune system. We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response to certain pathological conditions, such as cancer and infections. The present review comprises four main themes: (1) an overview of plant lectins that exert immunomodulatory effects and the mechanisms accounting for these activities; (2) general characteristics of the immunomodulatory lectin ArtinM from the seeds of Artocarpus heterophyllus; (3) activation of innate immunity cells by ArtinM and consequent induction of Th1 immunity; (4) resistance conferred by ArtinM administration in infections with intracellular pathogens, such as Leishmania (Leishmania) major, Leishmania (Leishmania) amazonensis, and Paracoccidioides brasiliensis. We believe that this review will be a valuable resource for more studies in this relatively neglected area of research, which has the potential to reveal carbohydrate targets for novel prophylactic and therapeutic strategies.

show abstract

“…The high IFN-γ response indicates that rML administration stimulates Th1 cells, which may mediate an antitumor T-cell response (reviewed by Zwierzina et al . [19]).…”

Section: Overview Of Immunomodulatory Plant Lectinsmentioning

confidence: 99%

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Regarding to the biological role of lectins, it appears that they are made to act in the inside and in the outside of the plants, as a tool or reaction mediators including agricultural (plant defense against the pathogens) (Peumans & Van Damme, 1995), immunology (antimicrobial and immunomodulatory) ( Ryder et al, 1992;Wang et al, 1996;Rubinstein et al, 2004;, serology (identification blood cell banks) (Boyd & Shapleigh, 1954;Khan et al, 2007;Meite et al, 2008), cancer (histochemical markers such as cancer and toxicity of cancer cell lines) (Guillot et al, 2004;Liu et al, 2010;Zwierzina et al, 2011), biochemistry (characterization, isolation and purification) (Hirabayashi, 2004;Peumans & Van Damme, 1998), and other biological field (reserve role, hormonal mimicry and enzymatique mimicry) (Meite et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Lectin Compounds and Immunomodulatory Activities of Protein Extracted From Plants

Daoudi¹,

Abdel-Satter²,

Aarab³

2013

JPS

View full text Add to dashboard Cite

Lectins are carbohydrate-binding proteins of non-immune origin. They are essential components of plant active substances used by the plant in its system of defense and symbiotic interactions. It is expected that there is a relation between immunomodulatory activity of the protein extract and its content of lectin. In this study, we are aiming to explore the relation between the lectin content and the immunomodulatory activity using the erythroagglutination test of a group of immunomodulating protein plant extracts previously evaluated. The result shows that there is no relationship between the immunostimulatory activity and the presence or absence of lectins; lectins are not always immunostimulatory compounds; and they can also depressed immune activity. The erythro-agglutination is found qualitatively and quantitatively depending on the nature of lectin and its concentration in the protein extracted. Therefore, the lectin immunostimulatory effects found can also be used with an adjuvant effect in vaccine development; while, the lectin immunoinhibitory effects can be used in the cancer therapy.

show abstract

“…Both microorganisms are well-established platforms for the production of recombinant proteins, including several approved biopharmaceutical products (Berlec and Strukelj, 2013; Gasser et al, 2013). These are also the most employed hosts for the production of recombinant lectins, namely plant lectins for biomedical purposes, such as jacalin (Sahasrabuddhe et al, 2004, 2006), aviscumin (from Viscum album ; Zwierzina et al, 2011), PCL (from Polygonatum cyrtonema ; Li et al, 2011), Orysata (from Oryza sativa ; Al Atalah et al, 2011), and GNA maize (from Galanthus nivalis ; Fouquaert et al, 2009). E. coli is commonly used to produce non-glycosylated lectins, while P. pastoris is mainly employed to overcome problems of insoluble expression of the bacterial system and to produce glycosylated lectins.…”

Section: Outlinementioning

confidence: 99%

Recombinant production of plant lectins in microbial systems for biomedical application â€“ the frutalin case study

Oliveira¹,

Teixeira²,

Domingues³

2014

Front. Plant Sci.

View full text Add to dashboard Cite

Frutalin is a homotetrameric partly glycosylated α-D-galactose-binding lectin of biomedical interest from Artocarpus incisa (breadfruit) seeds, belonging to the jacalin-related lectins family. As other plant lectins, frutalin is a heterogeneous mixture of several isoforms possibly with distinct biological activities. The main problem of using such lectins as biomedical tools is that “batch-to-batch” variation in isoforms content may lead to inconstant results. The production of lectins by recombinant means has the advantage of obtaining high amounts of proteins with defined amino-acid sequences and more precise properties. In this mini review, we provide the strategies followed to produce two different forms of frutalin in two different microbial systems: Escherichia coli and Pichia pastoris. The processing and functional properties of the recombinant frutalin obtained from these hosts are compared to those of frutalin extracted from breadfruit. Emphasis is given particularly to recombinant frutalin produced in P. pastoris, which showed a remarkable capacity as biomarker of human prostate cancer and as apoptosis-inducer of cancer cells. Recombinant frutalin production opens perspectives for its development as a new tool in human medicine.

show abstract

The preclinical and clinical activity of aviscumine: A potential anticancer drug

Cited by 44 publications

References 36 publications

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

The Relationship Between Lectin Compounds and Immunomodulatory Activities of Protein Extracted From Plants

Recombinant production of plant lectins in microbial systems for biomedical application â€“ the frutalin case study

Contact Info

Product

Resources

About