The precise determination of the window of implantation significantly improves ART outcomes

Enciso, María; Aizpurúa, Jon; Rodríguez-Estrada, B; Jurado, Inmaculada; Ferrández-Rives, Mariola; Rodrı́guez, Emma; Pérez-Larrea, E; Climent, A.; Marron, Kevin; Sarasa, Jonás

doi:10.1038/s41598-021-92955-w

Cited by 43 publications

(35 citation statements)

References 41 publications

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“…PIR formation before embryo arrival at the implantation site could be key to successful implantation, even in monotocous species, independent of embryo spacing. Such knowledge can be useful in enhancing assisted reproductive technologies where the optimal stage and timing for embryo transfer during the window of implantation is still not understood ( Enciso et al, 2021 ; Mackens et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Aberrant uterine folding in mice disrupts implantation chamber formation and alignment of embryo-uterine axes

et al. 2022

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The uterine luminal epithelium folds characteristically in mammals including humans, horses and rodents. Improper uterine folding in horses results in pregnancy failure but the precise function of folds remains unknown. Here we uncover dynamic changes in the 3D uterine folding pattern during early pregnancy with the entire lumen forming pre-implantation transverse folds along the mesometrial-antimesometrial axis. Using a time course we show that transverse folds are formed prior to embryo spacing whereas implantation chambers form as the embryo begins attachment. Thus folds and chambers are two distinct structures. Transverse folds resolve to form a flat implantation region after which an embryo arrives at its center to attach and form the post-implantation chamber. Our data also suggests that the implantation chamber facilitates embryo rotation and its alignment along the uterine mesometrial-antimesometrial axis. Using WNT5A- and RBPJ-deficient mice that display aberrant folds, we show that embryos trapped in longitudinal folds display embryo-uterine axes misalignment, abnormal chamber formation and defective post-implantation morphogenesis. These mouse models with disrupted uterine folding provide an opportunity to understand uterine structure-based mechanisms crucial for implantation and pregnancy success.

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Section: Discussionmentioning

confidence: 99%

Aberrant uterine folding in mice disrupts implantation chamber formation and alignment of embryo-uterine axes

et al. 2022

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“…The ER Map was evaluated in a non-RIF population and resulted in 302 clinical pregnancies out of 681 patients employing pET (44.35% pregnancy rate), which is significantly higher compared to 15 out of 65 clinical pregnancies when the ET was performed outside the WOI. However, the ER Map has not been evaluated in comparison to the standard ET protocol [ 67 ]. The ER Peak was evaluated in a retrospective study analyzing the clinical pregnancy and live birth rates of 550 RIF patients.…”

Section: Resultsmentioning

confidence: 99%

Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature

Maziotis

Kalampokas

Giannelou³

et al. 2022

Diagnostics

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Despite the advances in the field of reproductive medicine, implantation failure represents a challenging condition affecting 10–30% of patients subjected to in vitro fertilization (IVF). Research has focused on the identification of molecules playing crucial roles in endometrial receptivity, with the aim of designing predictive tools for efficient detection of the implantation window. To that end, novel molecular genomic and transcriptomic approaches have been introduced as promising tools to enable personalized approaches with the aim of optimizing embryo transfer dating. However, the clinical value of these approaches remains unclear. The aim of this study is to provide a systematic review and critical analysis of the existing evidence regarding the employment of commercially available novel approaches to evaluate endometrial receptivity. An Embase and PubMed/Medline search was performed on 1 February 2022. From the 475 articles yielded, only 27 were included and analyzed. The considerable heterogeneity of the included articles indicates the uniqueness of the implantation window, showcasing that the optimal time for embryo transfer varies significantly between women. Moreover, this study provides information regarding the technical aspects of these advanced molecular tools, as well as an analysis of novel possible biomarkers for endometrial receptivity, providing a basis for future research in the field.

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“…The endometrium undergoes a receptive period during the menstrual cycle where blastocysts can invade.This period is defined as the “window of implantation” and is of limited duration [ 13 ]. Precise determination of the window of implantation can significantly improve the efficacy of assisted reproductive technology (ART) [ 14 ]. It is well established that endometrial elastography reflects biochemical and molecular changes in the endometrium throughout the menstrual cycle [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the clinical application of ultrasound elastography in uterine imaging

Wang

Lin

2022

Insights Imaging

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Changes in tissue stiffness by physiological or pathological factors in tissue structure are identified earlier than their clinical features. Pathological processes such as uterine fibrosis, adenomyosis, endometrial lesions, infertility, and premature birth can manifest as tissue elasticity changes. In clinical settings, elastography techniques based on ultrasonography, optical coherence tomography, and magnetic resonance imaging are widely used for noninvasive measurement of mechanical properties in patients, providing valuable tool and information for diagnosis and treatment. Ultrasound elastography (USE) plays a critical role in obstetrics and gynecology clinical work because of its simplicity, non-invasiveness, and repeatability. This article reviews the recent progress of USE in uterine tumor diagnosis (especially early diagnosis and treatment effect evaluation), prediction of preterm birth, and intrauterine insemination. We believe that USE, especially shear wave elastography, may serve as a potential means to assess tissue stiffness, thereby improving the diagnosis and treatment of adenomyosis, fibroids, endometrial lesions, cervical cancer, and precise management of preterm birth and intrauterine insemination monitoring.

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The precise determination of the window of implantation significantly improves ART outcomes

Cited by 43 publications

References 41 publications

Aberrant uterine folding in mice disrupts implantation chamber formation and alignment of embryo-uterine axes

Aberrant uterine folding in mice disrupts implantation chamber formation and alignment of embryo-uterine axes

Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature

Advances in the clinical application of ultrasound elastography in uterine imaging

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