The Prebiotic Stage and the Evolution of Life on Earth

Ghiorghiţă, Gogu; Surpateanu, Gheorghe

doi:10.5539/enrr.v9n2p86

Cited by 4 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the analyzed publications [1][2][3][4][5][6] through the CRISPR/Cas adaptation system, to the macro-organism.…”

Section: Introductionmentioning

confidence: 99%

The Main Genome is the Source of Viruses

Vladyko

2023

AJBSR

View full text Add to dashboard Cite

The appearance of coronaviruses, like other viruses in mammals, is provoked by environmental factors -xenobiotics, formed mainly due to unreasonable human activity and resulting from the formation of an ecological (epidemiological) niche filled with molecular motifs of the intestinal microbiota using, for example, CRISPR/Cas mechanism, when these motifs try to adapt the immune and hormonal systems. It all depends on how much xenobiotics damage the immune and hormonal systems. Therefore, viruses are not the cause, but the consequence of the disease. The fight against viruses with the help of vaccines prepared on their basis has disrupted and delayed the natural mechanisms of regulation of biological processes in plants and mammals for more than 200 years (since the discovery of the smallpox vaccine). Thus, viruses arise from bacteria, and adaptation ends with microbiota bacteria, which can cause disease or, as a rule, in a healthy organism, the stage of bacterial infection is asymptomatic. In the latter case, the molecular motifs of the microbiota are adaptogens, not apoptogens (viruses) and spread in the environment, adapting or infecting others. This mechanism is also applicable to somatic diseases, such as cardiovascular, autoimmune, oncological, etc. Structural and functional features of SARS-CoV-2 proteins suggest that its main property is the ability to suppress innate and acquired nonspecific viral immunity in the respiratory tract (unlike HIV, in which all immunity is suppressed). This led to the reactivation of chronic, mainly bacterial, respiratory infections -pneumococci, staphylococci, hemophiluses, however, fungal infections can also be observedmucormycosis, aspergillosis, etc. This feature of the coronavirus prompted doctors at the beginning of the epidemic (2020) to use a pneumococcal vaccine, which, as it turned out, similarly to the coronavirus vaccine reduces the severity of the disease and mortality. We propose a technology of individual vaccination based on personal diagrams of human antibody clones specific to new circulating molecular motifs. Analysis of the profile of antibodies, namely their individual clones to the antigenic structures of the virus in humans before vaccination, should serve as a basis for excluding or including individual immunogens in a personal vaccine. In the future, the data from the antibody diagrams of each person can be transferred to a USB flash drive and used to obtain an aerosol or a nutritional cocktail formed from bifidobacteria adapted to infectious agents by a natural mechanism: xenobiotic (a new structure of the antigen) -a bacterium.

show abstract

“…From the analyzed publications [1][2][3][4][5][6] through the CRISPR/Cas adaptation system, to the macro-organism.…”

Section: Introductionmentioning

confidence: 99%

The Main Genome is the Source of Viruses

Vladyko

2023

AJBSR

View full text Add to dashboard Cite

show abstract

“…The further evolution of living organisms (plants and animals) depended on the appearance of land and, of course, depended on bacteria. Man appeared in this evolutionary process of bacteria 2.6-2.8 million years ago [3,4]. This "legacy" as a factor of breeding has remained and exists at the present time.…”

Section: Introductionmentioning

confidence: 99%

The Main Genome is a Source of Adaptogens and the Basis for the Development of a New Vaccination Technology

Vladyko,

Petkevich

2023

J. Environ. Sci. Eng. Technol.

View full text Add to dashboard Cite

The appearance of viruses in mammals and plants is provoked by environmental factors - xenobiotics, formed mainly due to unreasonable human activity and resulting from the formation of an ecological (epidemiological) niche filled with molecular motifs of the microbiota - the intestines of mammals and the root system of plants. To do this, bacteria and archaea use retrovirus-like “cut and paste” mechanisms, including, for example, the CRISPR/Cas system, when the molecular motifs of the microbiota try to adapt the immune and hormonal systems. It all depends on how much xenobiotics damage the immune and hormonal systems. Therefore, viruses are not the cause, but the consequence of the disease. The fight against viruses with the help of vaccines prepared on their basis has been violating and restraining the natural mechanisms of regulation of biological processes in plants and mammals. Thus, molecular motifs arising from microbiota bacteria become either apaptogens (viruses) or adaptogens. In the first and second cases, genetic information is released into the environment. In the latter case, there is an adaptation or a kind of vaccination of others by a natural mechanism. This mechanism is also applicable to somatic diseases, such as cardiovascular, autoimmune, oncological, etc. As for the original properties of coronaviruses, it is their ability to suppress innate and acquired nonspecific viral immunity in the respiratory tract. This leads to the reactivation of chronic, mainly bacterial, respiratory infections - pneumococci, staphylococci, hemophiluses, however, fungal infections can also be observed – mucormycosis, aspergillosis, etc. This feature of the virus prompted doctors at the beginning of the epidemic (2020) to use a pneumococcal vaccine, which, as it turned out, similarly to the coronavirus vaccine reduces the severity of the disease and mortality. As for the diagnosis of coronavirus infection and its treatment, as practice has shown, everything depends on the stage of the disease, starting with a viral and ending with a bacterial infection. Similar and identical antigenic determinants in coronavirus and respiratory group bacteria often caused confusion when analyzing the results of serological and molecular biological diagnostic tests in patients with COVID-19. Moreover, the justified use of antibiotics in the post-viral, that is, in bacterial periods, made it possible to successfully treat patients with a positive PCR test for coronavirus on an outpatient basis.

show abstract

“…According to the synthon theory [1][2][3] on the formation of proteinogenic amino acids and of corresponding polypeptides at low temperatures, aziridinone would have been formed from three synthons: methylene, nitrene and carbon monoxide. This one, in contact with these three synthons, somewhere outside the Earth's atmosphere, would form the precursor of radical structures.…”

Section: Introductionmentioning

confidence: 99%

Synthone Chemistry. Theoretical Study on the Formation of Valine, Leucine, Isoleucine and Methionine

Surpateanu¹,

Georgescu²,

Nistor³

et al. 2020

Rev. Chim.

Self Cite

View full text Add to dashboard Cite

According to synthonic theory of the formation of proteinogenic amino acids and of corresponding polypeptides, starting from three synthons (methylene, nitrene and carbon monoxide), four proteinogenic amino acids have been constructed: valine, leucine, isoleucine and methionine. This paper represents a theoretical, thermodynamic and reactivity study on the formation of the four previously mentioned amino acids at low temperatures. All the intermediates involved in the formation of these amino acids as well as the final products obtained by contact with water, an essential component of the Earth`s primary atmosphere, are specified. Quantitative data, formation enthalpies, reaction enthalpies and free energies were obtained in principle by DTF (B88-LYP) calculations.

show abstract

The Prebiotic Stage and the Evolution of Life on Earth

Cited by 4 publications

References 54 publications

The Main Genome is the Source of Viruses

The Main Genome is the Source of Viruses

The Main Genome is a Source of Adaptogens and the Basis for the Development of a New Vaccination Technology

Synthone Chemistry. Theoretical Study on the Formation of Valine, Leucine, Isoleucine and Methionine

Contact Info

Product

Resources

About