The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community

Milne, Fiona; Redman, C.W.G.; Walker, James J.; Baker, Philip N.; Bradley, Julian; Cooper, Carol; Swiet, Michael de; Fletcher, Gillian; Jokinen, Mervi; Murphy, Deirdre J; Nelson‐Piercy, Catherine; Osgood, Vicky; Robson, Stephen C.; Shennan, Andrew; Tuffnell, Angela; Twaddle, Sara; Waugh, Jason

doi:10.1136/bmj.330.7491.576

Cited by 278 publications

(167 citation statements)

References 19 publications

(15 reference statements)

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“…Blood samples from 5 patients with preeclampsia and 5 controls were also collected before delivery. Preeclampsia was defined as blood pressure > 140/90 mm Hg and proteinuria > 0.3 g/L (24). Patients with essential hypertension or other systemic diseases were excluded.…”

Section: Sample Collectionmentioning

confidence: 99%

Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes

Centlow

Carninci²,

Nemeth

et al. 2008

Fertility and Sterility

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Using microarrays made with cDNAs from subtracted placental libraries, we show increased hemoglobin production in the preeclamptic placenta. Heme and hemoglobin may cause endothelial damage and inflammation and drive pathological changes in the placenta if they are released there. Study Objective:To create a library enriched in cDNAs from preeclamptic placentas to print on to microarrays for placental profiling of preeclampsia (PE) and high risk pregnancies. Design: Prospective study.Setting: University women's clinic and academic research laboratory.Patients: Ten patients with PE, 5 with PE and bilateral notching, 5 with bilateral notching without PE, and 15 normotensive patients were recruited.Interventions: Placenta and placenta bed biopsies were collected after delivery. Main Outcome Measures:Subtracted libraries of PE transcripts were produced, and cDNAs from these libraries were used to make PE-specific cDNA arrays. Results were verified quantitatively using real-time PCR and histologically using in situ hybridization and immunohistochemistry.Results: 30 genes were significantly altered in at least one group comparison. Differences in two candidate genes were confirmed using quantitative rt-PCR. Hemoglobin α2 and γ transcripts were significantly over-expressed in the PE placenta. Scattered cells in the placenta and placental blood vessels were shown to express genes encoding these hemoglobin-chains. Conclusions:We demonstrate increased hemoglobin production in the PE placenta. The hemoglobin may be released into the placenta blood vessel lumen. Free heme and hemoglobin are potent toxins which cause endothelial damage and inflammation.

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Section: Sample Collectionmentioning

confidence: 99%

Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes

Centlow

Carninci²,

Nemeth

et al. 2008

Fertility and Sterility

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“…Different populations and ethno-geographical groups may have different risk factors. 2 It is important to establish the individual contribution of the various risk factors for the development of PE, most relevant to the particular population. Such studies in African women are limited.…”

Section: Introductionmentioning

confidence: 99%

“…1 In an average UK population, the incidence of PE is less than 1 in 20 women. 2 According to the National Institute of Clinical Excellence (NICE) antenatal guidelines, a woman's level of risk for PE in a given pregnancy should be assessed at the first antenatal visit by identifying the presence of one or more predisposing historical risk factors, and they should be supervised more vigilantly and managed at centers with facilities for specialized neonatal and maternal intensive care. 1 In the guidelines, some of the risk factors for the development of PE are: first pregnancy; previous PE; >10 years since last baby; age >40 years; body mass index (BMI) >35; family history of PE; booking diastolic blood pressure (BP) 80 mmHg; proteinuria at booking of +1 on more than one occasion or 300 mg/24 h; multiple pregnancy; and underlying medical conditions.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for pre-eclampsia among women at antenatal booking in Kano, Northern Nigeria

Yakasai

Morhason-Bello

2013

Healthc Low Resour Settings

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Pre-eclampsia (PE) is an important cause of maternal mortality. There have been several studies on risk factors assessment with conflicting reports across the globe on this disease; however, rigorous recent evaluation of these factors is uncommon in this region. The aim of the present study was to determine the risks factors in the early-onset PE in Aminu Kano Teaching Hospital (AKTH), Kano (Northern Nigeria). We conducted a case-control study in Nigeria between April 2009 and January 2010 to identify the risk factors associated with the early-onset PE in women attending antenatal clinic in AKTH. Information on socio-cultural characteristics, medical history, previous obstetrics history, level of stress at home, and type of family were obtained and recorded in a proforma designed for the study. Multiple logistic regression analysis was used to determine the risk factors for PE at 95% confidence level. Pregnant women with early-onset PE (150 in each case and control group). Risk factors associated with increased risk of early-onset PE were: history of pre-eclampsia/eclampsia (PE/E) in a previous pregnancy [adjusted odds ratio (AOR) 2.09]; exposure to passive smoking (AOR 1.34); inadequate antenatal supervision (AOR 15.21); family history of hypertension in one or more 1 st -degree relative (AOR 8.92); living in a joint family (AOR 6.93); overweight (120% to 150% of pre-pregnancy ideal body weight, AOR 4.65). Risk factors among women in Northern Nigeria are similar to those reported from other studies. Good antenatal cares, early detection, reduction of stressful conditions at home are the most important preventive measures of early-onset severe PE among these women.

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“…reported a relative risk of 7.19 (5.85-8.83) for recurrent PE [22]. Sibai et al, in their landmark study, [11] reported a recurrence of PE in nearly two thirds of pregnant women.…”

Section: Referencesmentioning

confidence: 99%

Risk for Recurrence of Pre-eclampsia in the Subsequent Pregnancy

Surapaneni

2013

JCDR

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The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community

Cited by 278 publications

References 19 publications

Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes

Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes

Risk factors for pre-eclampsia among women at antenatal booking in Kano, Northern Nigeria

Risk for Recurrence of Pre-eclampsia in the Subsequent Pregnancy

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