The PRAISE study: A prospective, multi-center, randomized, double blinded, placebo-controlled study for the evaluation of iloprost in the early postoperative period after liver transplantation (ISRCTN12622749)

Barthel, Erik R.; Rauchfuß, F.; Hoyer, Heike; Breternitz, Maria; Jandt, Karin; Settmacher, Utz

doi:10.1186/1471-2482-13-1

Cited by 25 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This local strategy may have benefitted from the more localized higher bioactive PTH level and the longer action time in the local defect sites. Given the 8 min half-life of PTH [38], only a part of the total bioactive PTH could reach the defect sites considering the bioactivity loss during circulation time when PTH is given systemically. On the contrary, the local delivery strategy is more likely to maintain bioactive PTH level within an effective range for a period of time.…”

Section: Discussionmentioning

confidence: 99%

Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold

et al. 2017

View full text Add to dashboard Cite

Parathyroid hormone (PTH) is currently the only FDA-approved anabolic drug to treat osteoporosis, and is systemically administered through daily injections. A new local pulsatile PTH delivery device was developed from biodegradable polymers to expand PTH’s application from osteoporosis treatment to spatially controlled local bone defect regeneration in this work. This is the first time that local pulsatile PTH delivery has been demonstrated to promote bone regeneration via enhanced bone remodeling. The biodegradable delivery device was designed to locally deliver PTH in a preprogrammed pulsatile manner. The PTH delivery was utilized to facilitate the regeneration of a bone defect spatially defined with a cell-free biomimetic nanofibrous (NF) scaffold. The local pulsatile PTH delivery (daily pulse for 21 days) not only promoted the regeneration of a critical-sized bone defect with negligible systemic side effects in a mouse model, but also advantageously achieved higher quality regenerated bone than the standard systemic PTH injection. These results demonstrate a promising and novel pulsatile PTH delivery device for spatially defined local bone regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Several studies have demonstrated the superiority of the VATS approach over sternotomy such as a smaller incisions with better cosmesis and less trauma to the chest wall, a decreased post-operative stay, a complete remission and no difference in outcome as compared to the open approach allowing an early adjuvant chemo-radiation treatment in advanced cases. However, most of the authors use the VATS approach when the tumor diameter is less than 5 cm or 6 cm, not involving the innominate vein, with little or no evidence of invasion or compression of major mediastinal structures [32] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] . Furthermore, VATS is considered a better approach for less intra-operative blood loss and early removal of chest drains.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in the surgical treatment of thymomas, VATS thymectomy is considered as a progressively suitable and efficacious alternative to open surgery. The da Vinci system robotic video-assisted thoracoscopic approach (R-VATS) is another minimally invasive surgical approach to thymectomy with potentially less morbidity [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] . This robotic approach has outcomes comparable to conventional video-assisted techniques.…”

Section: Discussionmentioning

confidence: 99%

Surgical approach in thymectomy: Our experience and review of the literature

Crescenzo

Napolitano

Panico

et al. 2017

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

AimThymectomy is the main treatment for thymoma and patients with myasthenia gravis (MG). The traditional approach is through a median sternotomy, but, recently, thymectomy through minimally invasive approaches is increasingly performed. Our purpose is an analysis and discussion of the clinical presentation, the diagnostic procedures and the surgical technique. We also consider post-operative complications and results, over a period of 5 years (May 2011–June 2016), in thymic masses admitted in our Thoracic Surgery Unit.MethodsWe analyzed 8 patients who underwent surgical treatment for thymic masses over a period of 5 years. 6 patients (75%) had thymoma, 2 patients (25%) had thymic carcinomas. 2 patients with thymoma (33%) had myasthenia gravis. We performed a complete surgical resection with median sternotomy as standard approach.ResultsOne patient (12%) died in the postoperative period. The histological study revealed 6 (75%) thymoma and 2 (25%) thymic carcinomas. Post-operative morbidity occurred in 2 patients (25%) and were: pneumonia in 1 case (12%), atrial fibrillation and pleural effusion in 2 patients (25%). One patient with thymoma type A recurred at skeletal muscle 2-years after surgery.ConclusionsThymic malignancies are rare tumors. Surgical resection is the main treatment, but a multimodal approach is useful for many patients. Radical thymectomy is completed removing all the soft tissue in the anterior mediastinum between the two phrenic nerves and this is the most important factor in controlling myasthenia and influencing survival in patients with thymoma. Open (median sternotomy) approach has been the standard approach for thymectomy for the better visualization of the anatomical structures. Actually, video-assisted thoracoscopic surgery (VATS) thymectomy and robotic video-assisted thoracoscopic (R-VATS) approach versus open surgery has an equal if not superior oncological efficacy, better perioperative complications and survival outcomes.

show abstract

“…Other work suggests surgeons do not find P-PASS particularly helpful in their decision to accept organs. 11 …”

Section: Discussionmentioning

confidence: 99%

Donor Characteristics of Pancreas Transplantation in Australia and New Zealand: A Cohort Study 1984-2014

Peng

Kelly

Mulley

et al. 2016

Transplantation Direct

View full text Add to dashboard Cite

BackgroundThe aim of this study was to audit the characteristics of pancreas donors over time in Australia and New Zealand. Pancreas transplantation was introduced in Australian and New Zealand in 1984.MethodsWe analyzed data from the Australia and New Zealand Islet and Pancreas Transplant Registry, 1984 to 2014. We investigated the variation of donor characteristics of sex, age, body mass index, smoking status, blood group, multiple organ donation, cytomegalovirus status, terminal creatinine, hypertension, and cause of death for pancreas transplantation over time. We used χ2 test (Fisher test when necessary) or analysis of variance to test difference for categorical or continuous characteristics, respectively.ResultsThere were 628 pancreas donors from 1984 to 2014. Donor body mass index (from 21.9 to 24.0, P < 0.001) and age (from 23.9 to 28.5, P = 0.02) have both increased while terminal creatinine has decreased (86.3 to 73.3, P = 0.01) from 1995 to 2014. In the meantime, the proportions of donors with hypertension (from 19% to 1%, P < 0.001) and who were smokers (from 54% to 15%, P < 0.001) have decreased. Profile of cause of donor death has also changed over time (P = 0.06) with increase in cerebral hypoxia/ischemia (from 3% to 17%) and reductions in intracranial hemorrhage (27% to 13%).ConclusionsMany donor characteristics have changed over time. The most significant changes appear to reflect changes in the general population, rather than changes in donor selection.

show abstract

The PRAISE study: A prospective, multi-center, randomized, double blinded, placebo-controlled study for the evaluation of iloprost in the early postoperative period after liver transplantation (ISRCTN12622749)

Cited by 25 publications

References 29 publications

Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold

Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold

Surgical approach in thymectomy: Our experience and review of the literature

Donor Characteristics of Pancreas Transplantation in Australia and New Zealand: A Cohort Study 1984-2014

Contact Info

Product

Resources

About