The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal

Roggers, Robert A.; Kanvinde, Shrey; Boonsith, Suthida; Oupický, David

doi:10.1208/s12249-014-0142-7

Cited by 62 publications

(29 citation statements)

References 66 publications

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“…For this reason, Si-NPs have been widely used in gene transfection, drug delivery, biosensing and bioimaging [164–166]. It has been observed that these nanostructures promote osteoblast differentiation through autophagy stimulation [167].…”

Section: Targeting Autophagy With Metal-based Nanoparticles As Therapmentioning

confidence: 99%

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Cordani

Somoza

2018

Cell. Mol. Life Sci.

150

105

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Despite the extensive genetic and phenotypic variations present in the different tumors, they frequently share common metabolic alterations, such as autophagy. Autophagy is a self-degradative process in response to stresses by which damaged macromolecules and organelles are targeted by autophagic vesicles to lysosomes and then eliminated. It is known that autophagy dysfunctions can promote tumorigenesis and cancer development, but, interestingly, its overstimulation by cytotoxic drugs may also induce cell death and chemosensitivity. For this reason, the possibility to modulate autophagy may represent a valid therapeutic approach to treat different types of cancers and a variety of clinical trials, using autophagy modulators, are currently employed. On the other hand, recent progress in nanotechnology offers plenty of tools to fight cancer with innovative and efficient therapeutic agents by overcoming obstacles usually encountered with traditional drugs. Interestingly, nanomaterials can modulate autophagy and have been exploited as therapeutic agents against cancer. In this article, we summarize the most recent advances in the application of metallic nanostructures as potent modulators of autophagy process through multiple mechanisms, stressing their therapeutic implications in cancer diseases. For this reason, we believe that autophagy modulation with nanoparticle-based strategies would acquire clinical relevance in the near future, as a complementary therapy for the treatment of cancers and other diseases.

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Section: Targeting Autophagy With Metal-based Nanoparticles As Therapmentioning

confidence: 99%

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Cordani

Somoza

2018

Cell. Mol. Life Sci.

150

105

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“…For compound 89,t he authors hypothesized that the quinone TML moiety might act as as econd antibacterial warhead inhibiting thiolcontaining enzymes, and this leads to ad ual-acting hybrid,a s illustrated in the box in Scheme 18. [129][130][131][132] In their report, Wu and co-workers modify the surfaces of the MSNPs with 3-aminopropylsiloxanes Scheme17. NQO1-sensitive quinone-type TML moieties have also been used for the stimuli-responsive controlled releaseo fc ompounds from modified liposomes and polymer-based nanoparticles.I n2 008, McCarley and co-workersr eported the synthesis of quinoneT ML dioleyl phosphatidylethanolamine (Q-DOPE) lipid 93 (Scheme 19).…”

Section: Quinone-oxidoreductase-sensitive Tml Systemsmentioning

confidence: 99%

Trimethyl Lock: A Multifunctional Molecular Tool for Drug Delivery, Cellular Imaging, and Stimuli‐Responsive Materials

Okoh

Klahn

2018

ChemBioChem

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Trimethyl lock (TML) systems are based on ortho-hydroxydihydrocinnamic acid derivatives displaying increased lactonization reactivity owing to unfavorable steric interactions of three pendant methyl groups, and this leads to the formation of hydrocoumarins. Protection of the phenolic hydroxy function or masking of the reactivity as benzoquinone derivatives prevents lactonization and provides a trigger for controlled release of molecules attached to the carboxylic acid function through amides, esters, or thioesters. Their easy synthesis and possible chemical adaption to several different triggers make TML a highly versatile module for the development of drug-delivery systems, prodrug approaches, cell-imaging tools, molecular tools for supramolecular chemistry, as well as smart stimuliresponsive materials.

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“…Different templating agents such as ionic surfactants, pluronic surfactants, and neutral block copolymers are further used to influence pore size and arrangement as well the MSN's general shape and size. [54] The use of polyelectrolyte gatekeepers, supramolecularnanovalves, pH-sensitive linkers, and acid-decomposable inorganic gatekeepers with MSNs to form a pH-responsive release system has also been studied to further enhance MSN delivery for the treatment of diseases such as cancer. [55] MSN-based systems have also been studied for the research of other stimuli-responsive delivery mechanisms for both endogenous stimuli such as enzymes and glucose and exogenous stimuli light and magnetics.…”

Section: Mesoporous Silica-based Nanoparticlesmentioning

confidence: 99%

“…[56] More research is still being conducted that focuses on the safety, biodegradability, pharmacokinetics, and biodistribution of MSNs. [54] Semiconductor Quantum Dots Semiconductor quantum dots have become attractive to researchers for siRNA delivery because of their usefulness in molecular imaging as fluorophores. As carriers, they exhibit biocompatibility.…”

Section: Mesoporous Silica-based Nanoparticlesmentioning

confidence: 99%

An Overview of Various Carriers for siRNA Delivery

Marquez¹,

Madu²,

Lü³

2018

Oncomedicine

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RNA interference through the use of short interfering molecules known as short interfering RNA (siRNA) has the potential to greatly advance research in treatments for many diseases because it has the ability to silence the expression of specific genes by helping degrade target mRNA. However, challenges to siRNA delivery have made the development of safe and effective delivery systems paramount in siRNA research. Various types of delivery systems have been proposed and investigated for siRNA delivery and therapy. Although viral vectors have been established to be the most effective in delivering siRNA molecules, they also raise many concerns over biosafety, especially concerning immunogenicity. Therefore, many researchers have begun to investigate and study non-viral vectors. Non-viral vectors are studied because they are typically considered to be safer than viral vectors albeit less efficient as well. The three general non-viral vectors that have been studied for siRNA delivery are lipid-based, non-lipid organic-based, and non-lipid inorganic-based carriers. Within those general parameters of non-viral vector classification are subtypes that are each unique with their own characteristic benefits and downsides. Many of these carriers, as well as even naked siRNA, do have the potential to be modified so that siRNA delivery could be further enhanced with benefits such as greater stability and duration. Researchers still must be wary with alterations as to not interfere with siRNA function. Currently, widespread siRNA therapeutics are still out of reach, but as more advancements in siRNA research including research on their delivery mechanisms are established, the goal of integrating siRNA therapy into the treatment of a multitude of diseases becomes increasingly more of a possibility. Researchers are currently investigating how siRNA can be used to not just treat cancer but ocular and neurodegenerative diseases as well as many others. There are still many obstacles to face and overcome before siRNA therapy can be implemented into the treatment of many diseases, and more research must still be conducted concerning siRNA delivery systems. Many advancements pertaining to siRNA carriers have been made, and many more are likely on their way.

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The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal

Cited by 62 publications

References 66 publications

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Trimethyl Lock: A Multifunctional Molecular Tool for Drug Delivery, Cellular Imaging, and Stimuli‐Responsive Materials

An Overview of Various Carriers for siRNA Delivery

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