The practical use of acetylsalicylic acid in the era of the ASPRE trial. Update and literature review

Kosiński, Przemysław; Nowacka, Urszula; Fiolna, M.; Wielgoś, Mirosław

doi:10.5603/gp.a2018.0018

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…The tested capsules had an average content weight of more than 300 mg/capsule; thus, the maximum acceptable weight variation was ±7.5% [7]. Table 3 shows maximum and minimum acceptance values at percentage of deviation allowed and at double the percentage of deviation allowed.…”

Section: Uniformity-of-mass Testmentioning

confidence: 99%

“…Moreover, the results of pharmaceutical studies have confirmed that continuous treatments with LDA can reduce the probability of developing such cancers as colorectal, esophageal, breast, lung, prostate, liver, and skin. Also, it was demonstrated that the administration of LDA before the 11th week of gestation in women might reduce the risk of preterm delivery [6], [7].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Evaluation of Extemporaneously Compounded Aspirin Capsules from Crushed Aspirin Tablets

Alfagih

Aljaliel

2021

JPRI

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Aims: Extemporaneous preparations of medications might bring about technical and clinical consequences due to formulation failures. Therefore, all such prepared formulas should undergo valid and reliable procedures supported by solid data. Otherwise, patients can experience significant risk due to microbial contamination or physical or chemical changes during the preparation process. Thus, effective extemporaneous preparation relies on correct calculations to avoid extra and serious harm. Therefore, because 50-mg aspirin capsules are not available in Saudi Arabia, this study aimed to formulate 50-mg capsules from available 100-mg aspirin tablets. Methodology: Quality control tests of the preparations were carried out at the time of preparation and after one month of storage at 25 °C and at 40 °C and 75% relative humidity. All tests were carried out according to the British and United States pharmacopeia monograph of aspirin. Results: The drug content assay and uniformity test indicated that the aspirin capsules were within the pharmacopeial limits. The disintegration time for all aspirin capsules was within the pharmacopeial limits of 30 minutes. The aspirin release profile showed that approximately 90% of the aspirin dissolved after 10 minutes. Conclusion: The results indicated that the extemporaneous preparation of ASA capsules complied with the quality control tests for freshly prepared capsules and after one month of storage at room temperature and at 40 °C and 75% relative humidity. The dissolution profile of these capsules indicates immediate and high release of ASA, which is essential to ensure the required absorption. This study is of great importance for patients who need to take this dose of ASA. Pharmacists can prepare good-quality capsules with the desired ASA content using a 100-mg ASA tablet as a source of the active ingredient.

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Section: Uniformity-of-mass Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Extemporaneously Compounded Aspirin Capsules from Crushed Aspirin Tablets

Alfagih

Aljaliel

2021

JPRI

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“…We cannot overlook the importance of using low doses of acetylsalicylic acid in the prevention of preeclampsia (PE) and intrauterine fetal growth disorder (IUGR) [15]. Preeclampsia is a dangerous complication for both the mother and the child.…”

Section: Prevention -Procedures To Reduce the Risk Of Cpmentioning

confidence: 99%

Cerebral palsy and obstetric-neonatological interventions

Młodawski¹,

Mlodawska²,

Pazera³

et al. 2019

Ginekol Pol

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Cerebral palsy is a disease that puts a great mental burden on caregivers and generates very high social costs. Children with CP require many years of rehabilitation and medical care. The etiology of the disease is undoubtedly multifactorial, and the pathogenesis is associated with focal damage to the central nervous system. One can find descriptions of well-documented interventions in the literature that reduce the risk of CP in certain groups of pregnant and neonatal patients, and interventions that have a potentially protective effect. In this review, we have analyzed the available literature in terms of prenatal and postnatal interventions that may have an impact on reducing the incidence of this condition in children.

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“…Recent meta-analyses and the results of randomized controlled ASPRE trials triggered a serious interest in first-trimester PE screening. A possibility of effective reduction in PE prevalence by early (before 16 weeks of gestation) implementation of aspirin has been recently well-described in the literature [7][8][9]. Although various studies report increased concentrations of cfDNA in women with confirmed PE, or shortly before the onset of PE, there is paucity of data on the predictive value of cfDNA testing at first-trimester visit [10,11].…”

Section: Cell Free Fetal Dna and Pementioning

confidence: 99%

Is there a future for cell-free fetal dna tests in screening for preeclampsia?

2019

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CffDNA screening is a powerful diagnostic tool in the prenatal diagnosis algorithm for chromosomal abnormalities. With detailed ultrasound examination as the mainstay of first-trimester risk assessment, cffDNA has been shown to be superior to first-trimester combined screening (FTCS) in false-positive rates for trisomy 21 detection. In light of the growing interest in cffDNA testing and the possibility of it replacing first-trimester biochemistry, we decided to investigate the usefulness of cffDNA tests in early-pregnancy risk assessment for preeclampsia (PE). The aim of this review paper was to evaluate clinical application of first-trimester cfDNA in predicting PE, as well as to investigate its possible use in first-trimester PE screening enhancement, also in cases where biochemistry is not performed.

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The practical use of acetylsalicylic acid in the era of the ASPRE trial. Update and literature review

Cited by 7 publications

References 25 publications

Preparation and Evaluation of Extemporaneously Compounded Aspirin Capsules from Crushed Aspirin Tablets

Preparation and Evaluation of Extemporaneously Compounded Aspirin Capsules from Crushed Aspirin Tablets

Cerebral palsy and obstetric-neonatological interventions

Is there a future for cell-free fetal dna tests in screening for preeclampsia?

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